Core Insights - The article discusses the transition from AI for Science (AI4S) to AGI for Science (AGI4S), emphasizing the need for a specialized generalist model to enhance scientific discovery and reasoning capabilities [1][2][71]. Group 1: Current State of AI in Science - AI for Science, exemplified by AlphaFold, has achieved significant milestones in specific fields like protein folding and weather prediction, but reliance on existing deep learning models may limit the exploration of new knowledge and hinder innovation [1][71]. - A systematic evaluation involving 100 scientists from 10 different scientific fields revealed that cutting-edge models scored 50 out of 100 in general scientific reasoning tasks, but dropped to scores between 15 and 30 in specialized reasoning tasks [1][71]. Group 2: The Need for AGI4S - The transition from AI4S 1.0 to AGI4S 2.0 is necessary to integrate general reasoning with specialized capabilities, addressing the limitations of current models in scientific discovery [2][71]. - The concept of "Specialized Generalist" is proposed as a feasible path to achieve AGI, which combines deep specialization with general capabilities [2][90]. Group 3: Technological Framework - SAGE - The "SAGE" architecture is introduced as a synergistic framework for developing generalizable experts, consisting of three layers: foundational, collaborative, and evolutionary [3][18]. - The foundational layer focuses on decoupling knowledge and reasoning capabilities, while the collaborative layer employs reinforcement learning to balance intuitive and logical reasoning [27][28]. - The evolutionary layer aims to enable self-evolution of models through continuous interaction and feedback, addressing the challenges of adapting to complex tasks [55][56]. Group 4: Innovations in Reinforcement Learning - The article highlights the development of the PRIME algorithm, which provides dense rewards for reinforcement learning without the need for extensive manual labeling, significantly improving model performance [38][39]. - FlowRL is introduced to enhance the diversity of reasoning paths in models, allowing them to explore multiple solutions rather than converging on a single answer [47][50]. Group 5: Applications and Case Studies - The Intern-S1 model is designed to be a deep specialized generalist for scientific applications, demonstrating superior performance in various scientific domains compared to existing models [77][79]. - The Intern-Discovery platform integrates the Intern-S1 model with extensive data and tools, facilitating a closed-loop system for hypothesis generation and experimental validation [80][84]. Group 6: Future Directions - The article calls for collaboration among researchers to fill the gaps in the current framework and advance the development of AGI4S, emphasizing the potential for AI to revolutionize scientific research [89][90].