使用BIRT 技术使RNA测序成本降低5倍，来源：Biostate AI 行业风口下的强强联合 随着精准医疗和基因组学技术的快速发展，全球基因组学领域的AI市场正在迅猛增长。市场研究报告 显示，2022年全球基因组学人工智能市场规模约为4.98亿美元，预计2023–2030年间将以46%的年复合 增长率快速扩大1。这一趋势得益于个性化医疗需求的激增和科研投入的增加。 而在基因组学与AI驱动的精准医疗浪潮中，数据质量与稀缺性已成为企业核心竞争力的关键指标。康 圣环球的 RNA 数据资源经过22年的积累与严格筛选，覆盖多种疾病类型、不同病程阶段以及多样的样 本来源，其规模与质量在行业内均属领先水平，将与 Biostate AI 的 Total RNA 测序技术形成绝佳互补。 通过革命性的低成本测序技术，大规模、经济高效的数据收集成为可能，从而为AI基础模型注入海量 高质量训练燃料。这一突破不仅让基因组学数据从"科研奢侈品"变为"普惠资源"，驱动更强大的AI模型 带来更精准的预测，更精准的预测反哺更优质的数据，形成"数据-算法-临床价值"正向循环的飞轮效 应。 目前，康圣环球已经与Biostate AI开展了在白血 ...

Core Viewpoint - The announcement highlights the equity changes of major shareholders in Nuohe Zhiyuan, indicating a reduction in their holdings, which may impact the company's stock performance and investor sentiment [1][2]. Shareholder Equity Changes - Beijing Zhiyuan Hegu Investment Management Center reduced its holdings by 2,077,773 shares (0.50%) through centralized bidding and 2,179,000 shares (0.52%) through block trading, decreasing its ownership from 11.32% to 10.30% [1][2]. - Beijing Nuohe Hegu Investment Management Center reduced its holdings by 217,488 shares (0.05%) through centralized bidding, with no shares sold through block trading, decreasing its ownership from 3.02% to 2.97% [1][2]. Total Shares Reduced - Between April 21, 2025, and June 3, 2025, a total of 4,474,261 shares were sold by both Zhiyuan Hegu and Nuohe Hegu [2]. Company Background - Nuohe Zhiyuan was listed on the Shanghai Stock Exchange's Sci-Tech Innovation Board on April 13, 2021, with an initial public offering (IPO) of 40.2 million shares at a price of 12.76 yuan per share, raising a total of 51,295.20 million yuan [2][3]. - The company intended to use the IPO proceeds for projects related to gene sequencing service platform expansion, gene testing reagent research and development, information technology and data center construction, and working capital [2]. Recent Fundraising Activities - In October 2023, Nuohe Zhiyuan announced a private placement of 16 million shares at a price of 20.76 yuan per share, raising a total of 332.16 million yuan, with net proceeds of approximately 327.61 million yuan after deducting issuance costs [3]. - The total fundraising from the IPO and the 2023 private placement amounts to 84,511.2 million yuan [4].

创业基金会 创心 之路 创业数据研究报告（2024） 第部分2024年创业投 | 1.2024年创业投资情况综述 | 01 | | | --- | --- | --- | | 2.2024年创业投资热点领域变化情况 | 05 | 日录 | | 2.1:2024年创投市场整体表现 | 05 | | | 2.22024创业投资热点变化超势 | 06 | | | 2:32024年与2023年对比分析 | 07 | | | 2.4热点行业排名变化情况 | 08 | | | 25人工智能领域出现爆发式增长 | 08 | | | 26.智能制造细分领减的热点主要是芯片新材料和新能添 | 09 | | | 2.7医疗健康细分领域的热点主要是生物技术、制药和医疗器械 | 10 | | | 3.2024年创业投资分布情况 | 12 | | | 4.2024年投资机构的变化情况 | 13 | | | 41投资机构呈现出数量稳定而结构多元化现象 | 13 | | | 4.22024年头部创业投资机构的变化情况 | 15 | | | 4.32024年重点行业活跃的投资机构变化情况 | 16 | | | 442024年代表性的创业投资 ...

登录新浪财经APP 搜索【信披】查看更多考评等级 证券代码：688289 证券简称：圣湘生物 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者重大遗漏，并对其内容 的真实性、准确性和完整性依法承担法律责任。 重要内容提示 公司董事会、监事会及董事、监事、高级管理人员保证季度报告内容的真实、准确、完整，不存在虚假 记载、误导性陈述或重大遗漏，并承担个别和连带的法律责任。 公司负责人、主管会计工作负责人及会计机构负责人（会计主管人员）保证季度报告中财务信息的真 实、准确、完整。 第一季度财务报表是否经审计 □是 √否 一、 主要财务数据 (一) 主要会计数据和财务指标 单位：元 币种：人民币 (二) 非经常性损益项目和金额 √适用 □不适用 单位:元 币种:人民币 对公司将《公开发行证券的公司信息披露解释性公告第1号——非经常性损益》未列举的项目认定为非 经常性损益项目且金额重大的，以及将《公开发行证券的公司信息披露解释性公告第1号——非经常性 损益》中列举的非经常性损益项目界定为经常性损益的项目，应说明原因。 □适用 √不适用 持股5%以上股东、前10名股东及前10名无限售流通股股东参与转 ...

Financial Data and Key Metrics Changes - The company generated revenue of $665 million in Q1 2025, resulting in 4% organic growth, with a 1% headwind from foreign exchange [27][31] - Adjusted EPS for the quarter was $1.01, exceeding expectations of $0.93 to $0.95 [7][29] - Adjusted operating margins were reported at 25.6%, slightly up year-over-year and above expectations [28] Business Line Data and Key Metrics Changes - Life Sciences segment revenue was $340 million, up 1% reported and 2% organically, with low single-digit growth in pharma biotech customers and a decline in academic and government customers [32] - Diagnostics segment revenue reached $324 million, up 3% reported and 5% organically, driven by high single-digit growth in immunodiagnostics [33] Market Data and Key Metrics Changes - The Americas and Europe experienced mid-single-digit growth, while Asia saw low single-digit growth, with China also growing in low single digits [31] - U.S. academic customers, representing over 5% of total revenue, showed cautious spending due to uncertainties in funding [23][24] Company Strategy and Development Direction - The company is focused on maintaining strong organic growth and operational agility to navigate macroeconomic challenges [5][20] - A recent expanded alliance with Genomics England aims to enhance newborn genomic sequencing capabilities, positioning the company as a leader in this area [9] - The software business, representing about 8% of total revenue, grew over 20% organically in Q1 and is expected to continue strong growth [13][15] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about the company's resilience and ability to adapt to changing market conditions, reaffirming a full-year adjusted EPS outlook of $4.9 to $5 [19][37] - The company anticipates a gross impact of approximately $135 million from tariffs, but expects to mitigate most of this through proactive measures [18][19] Other Important Information - The company repurchased $154 million of its shares in Q1, reducing the outstanding share count to 119.4 million [7][29] - The net debt to adjusted EBITDA leverage ratio was reported at 2.4 times, with all debt being fixed rate [30] Q&A Session Summary Question: Can you talk about the tariff impact and what products are affected? - Management indicated that they have been proactive in adjusting their supply chain to mitigate the $135 million gross tariff impact, focusing on products sold from the U.S. to China [41][43] Question: What are the expectations for the Life Sciences segment? - The Life Sciences segment is expected to see low single-digit growth, with instrumentation under pressure but solid growth in reagents [45][48] Question: How is the company managing its exposure in China? - The company expects low single-digit growth in China, with a slight decline in Life Sciences and mid-single-digit growth in Diagnostics [56] Question: What is the outlook for the software business? - The software business is expected to continue strong double-digit growth, with a focus on expanding into new markets [62][90] Question: What are the long-term margin expectations? - Long-term operating margin expectations remain unchanged, with a focus on SG&A volume leverage as growth continues [104]

导读： 本文欲探讨关税对测序设备、试剂、耗材及服务的影响，分析主要参与者的策略，窥探市场引发的连锁反应，跨国公司正积极寻求对策，本土制造商则有 机会筑建新的长城。 特别提示 微信公众号机制调整，请点击顶部"仪器信息网" → 右上方"…" → 设为 ★ 星标，否则很可能无法看到我们的推送。 导 读： 从研发角度，基于成本、技术以及国际合作方面分析，试图探索中美贸易摩擦持续升级下测序行业的机遇。 最近中美贸易摩擦持续升级，双方都对彼此的商品实施大幅度的关税增长，这些举措给我们测序行业带来了显著干扰和不确定，高额的关税阻 碍了设备、试剂以及耗材的进出口贸易，增加了研发和运营开销。 但往往不确定中就蕴含着机会，毕竟《孙子兵法·形篇》里面开篇就说"昔之 善战者，先为不可胜，以待敌之可胜"，意思是会打仗的人都先保证自己不败，然后等待敌人犯错。 当下大环境骤变，竞争格局即将重塑。本 文欲探讨关税对测序设备、试剂、耗材及服务的影响，分析主要参与者的策略，窥探市场引发的连锁反应，跨国公司正积极寻求对策，本土制 造商则有机会筑建新的长城。 放眼全球，测序是一个充满活力的市场，目前该行业主要由NGS驱动，这些技术使大规模基因组分析 ...