Core Insights - Recent research from Nantong University confirms that exposure to nanoplastics during pregnancy has transgenerational toxicity, revealing mechanisms behind this toxicity for the first time [1][2] Group 1: Research Findings - Nanoplastics degrade into smaller particles, leading to microplastics and potentially harmful effects on human health, with evidence found in placental and umbilical cord blood [1] - A mouse model study showed that maternal exposure to nanoplastics during pregnancy resulted in neuronal cell shrinkage and loss in offspring, along with increased markers associated with Alzheimer's disease [1] - Offspring exhibited multi-organ damage, with severity correlating to the level of exposure to nanoplastics [1] Group 2: Gender Differences and Mechanisms - Transgenerational toxicity of nanoplastics shows gender differences, with male offspring being more sensitive to lung damage and intestinal pathology compared to females [2] - A significant downregulation of SIRT1 protein was observed in affected organs of the offspring, which is crucial for cellular aging and stress response [2] - Virtual screening and molecular dynamics simulations indicated that extracts from the common traditional Chinese medicine, Jin Qiao Mai, can significantly upregulate SIRT1 activity in experimental mice, suggesting potential clinical interventions [2]

尽管当前研究已经揭示了微塑料可能对人体健康构成潜在风险，但其具体的毒性机制仍未完全明确。现有研究表明，微 塑料能够通过多种生物学机制对人体多个重要系统造成影响，包括 神经系统、泌尿系统和生殖系统等 。微塑料的毒性 作用不仅局限于单一器官或组织，还可能通过复杂的细胞信号通路和分子机制引发系统性损伤。 导读： 微塑料和纳米塑料（Microplastics/Nanoplastics, MNPs） 作为一种新型的环境污染物，因其微观尺寸、广泛分布以及难以 降解的特性，已成为全球范围内生态环境和公众健康领域的核心关注点。 特别提示 微信机制调整，点击顶部"仪器信息网" → 右上方"…" → 设为 ★ 星标，否则很可能无法看到我们的推送。 随着塑料制品的广泛使用和持续累积，微塑料已经被发现存在于自然界的各个领域，包括 水源、土壤、大气甚至生物 体内 。更令人担忧的是，微塑料已经通过多种途径进入人体，例如通过 食物链、饮用水、空气吸入以及皮肤 接触等 无处不在的方式。 据估计，个人在日常生活中可能无意中摄入大量微塑料，这种隐形污染正逐渐成为威胁人类健康的重要因素。 微塑料毒理作用研究进展 例如，微塑料能够通过诱导氧化应激、 ...