重组人胸腺素β4(NL005)
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诺思兰德(920047):北交所信息更新:NL005IIc期临床试验已完成CDE沟通,即将全面启动
KAIYUAN SECURITIES· 2025-12-08 06:47
Investment Rating - The investment rating for the company is "Outperform" (Maintain) [3] Core Insights - The company is set to officially launch the Phase IIc clinical trial for its self-developed recombinant human thymosin β4 (NL005) for the treatment of acute myocardial infarction (AMI) following successful communication with the CDE [4][5] - The company anticipates revenue growth from 0.89 billion yuan in 2025 to 6.11 billion yuan in 2027, with net profits projected to shift from a loss of 440 million yuan in 2025 to a profit of 730 million yuan in 2027 [4][7] - The company has established a significant partnership with a well-known domestic ophthalmology company to promote the localization of its balanced salt solution, enhancing its market presence in the ophthalmic medical sector [5] Financial Summary - Revenue projections for 2025-2027 are 0.89 billion yuan, 2.71 billion yuan, and 6.11 billion yuan respectively, with corresponding net profits of -440 million yuan, -20 million yuan, and 730 million yuan [4][7] - The company’s gross margin is expected to improve from 55.8% in 2025 to 71.5% in 2027, while the net margin is projected to turn positive by 2027 [7][10] - The price-to-sales (P/S) ratio is forecasted to decrease from 78.8 in 2025 to 11.5 in 2027, indicating a potential increase in valuation as revenues grow [4][7]
诺思兰德(920047):NL005Ⅱc期临床试验启动在即,增添成长动能
Shenwan Hongyuan Securities· 2025-12-03 09:46
Investment Rating - The report maintains an "Outperform" rating for the company [7] Core Insights - The company has completed the clinical trial communication for its self-developed drug NL005, aimed at treating acute myocardial infarction (AMI), and will officially start the Phase IIc clinical trial [4] - The domestic AMI mortality rate is on the rise, with approximately 50% of AMI patients experiencing myocardial reperfusion injury (MIRI) after treatment [7] - NL005 is expected to start Phase IIc clinical trials in the first half of 2026, with previous studies showing its effectiveness in reducing myocardial infarction area in animal models [7] - The report estimates a peak revenue of approximately 5.5 billion yuan for the product by 2034, applying a 3x price-to-sales (PS) ratio for valuation, leading to a reasonable market value of about 14.9 billion yuan [7] Financial Data and Profit Forecast - Total revenue projections for 2025E are 700 million yuan, with a year-on-year growth rate of -3.0% [6] - The net profit attributable to the parent company is forecasted to be -500 million yuan for 2025E [6] - The gross profit margin is expected to be 49.6% in 2025E, increasing to 71.5% by 2027E [6]