10月18日，中国证监会公布《境外发行上市备案补充材料要求(2025年10月12日—2025年10月17日)》。 其中，证监会要求天辰生物补充说明全额行使超额配售权后的预计募集资金量、公司股东OFC博晖基金 及OFC交子基金向上穿透后的情况等事项。据悉，天辰生物已于2025年8月21日向港交所主板提交上市 申请，国金证券(香港)为独家保荐人。 证监会请天辰生物补充说明以下事项，请律师核查并出具明确的法律意见： 三、请说明常熟东南、山证创新投资国有股东标识办理进展。 四、关于本次发行上市及"全流通"：(1)请说明全额行使超额配售权后的预计募集资金量；(2)请说明本 次拟参与"全流通"股东所持股份是否存在被质押、冻结或其他权利瑕疵的情形。 据招股书，天辰生物医药是一家致力于创新药开发的临床阶段生物制药公司，主要专注于针对过敏性及 自身免疫性疾病的生物药物的自主发现与开发。天辰生物医药已构建针对鼻科、皮肤科、呼吸科、血液 科、肾脏科及其他自身免疫性疾病的综合性生物制剂产品管线。 基于全球及中国自身免疫性疾病和过敏性疾病市场的预期增长，天辰生物医药已经并将继续依托(i)在开 发创新药方面的专业知识;(ii)两个自主研 ...

Core Viewpoint - Tianchen Biopharmaceuticals (Suzhou) Co., Ltd. has submitted its listing application, focusing on the development of biopharmaceuticals for allergic and autoimmune diseases, with significant financial losses reported since its establishment in 2020 [1][2]. Financial Performance - Tianchen Biopharmaceuticals has not generated any revenue since its inception, reporting losses of RMB 95.778 million, RMB 137.321 million, and RMB 94.208 million for the years 2023, 2024, and the first half of 2025, respectively, totaling approximately RMB 327 million over two and a half years [1][2]. - The company anticipates continued losses due to increased R&D investments and enhanced sales and marketing activities [2]. Cash Flow and Financing - The net cash flow from operating activities has shown a negative trend, with outflows of RMB 60.865 million, RMB 104.122 million, and RMB 47.673 million for the years 2023, 2024, and the first half of 2025, respectively [3][4]. - As of June 30, 2025, the company had cash and cash equivalents amounting to RMB 136.118 million, with financial assets valued at RMB 155 million [3]. Supply Chain Concentration - The company has a moderately concentrated supply chain, with purchases from the top five suppliers accounting for 48.58%, 51.65%, and 57.93% of total procurement for the years 2023, 2024, and the first half of 2025, respectively [4][5]. - Although this concentration is not deemed significantly high, the company is actively implementing strategies to mitigate potential risks, including diversifying supply bases and closely monitoring supplier performance [5].