Workflow
Cellgram
icon
Search documents
干细胞疗法:临床突破与资本热浪
Wind万得· 2025-05-26 22:40
Core Viewpoint - The article highlights the significant advancements and growing interest in stem cell therapy, particularly in China, as it is now included in national strategic plans and supported by various policies aimed at promoting research and clinical applications [1][3]. Group 1: Stem Cell Therapy Overview - Stem cell therapy utilizes the unique properties of stem cells to treat diseases or repair damaged tissues, with a total of 116 clinical trials approved or completed globally by December 2024, covering major diseases such as Parkinson's, diabetes, epilepsy, heart disease, and cancer [2]. - Stem cells can be classified into three main categories based on developmental stages: embryonic stem cells (ESCs), adult stem cells (ASCs), and induced pluripotent stem cells (iPSCs) [2]. Group 2: Regulatory Environment - The U.S. FDA has implemented strict yet gradually opening regulations for stem cell therapies, ensuring safety and stability through various legislative acts, including the "Regenerative Medicine Advanced Therapy" (RMAT) designation [3]. - China has also introduced supportive policies for the development of stem cell therapies, including the "14th Five-Year Plan for Bioeconomy" and the "Healthy China 2030" initiative, emphasizing the importance of stem cell technology [3]. Group 3: Market Growth - The global stem cell therapy market reached $380 million in 2023 and is projected to grow to $1.73 billion by 2030, indicating a significant expansion trend [4]. Group 4: Clinical Application Progress - The most actively researched types of stem cells include mesenchymal stem cells (MSCs) and iPSCs, with over 1,300 clinical trials related to MSCs globally, focusing on orthopedic, cardiovascular, and autoimmune diseases [5]. - The first MSC therapy, Cellgram, was approved in South Korea in 2011, and the first MSC therapy in the U.S., Ryoncil, was approved by the FDA in December 2024 for treating steroid-refractory acute graft-versus-host disease [6]. Group 5: iPSCs Development - As of November 2024, there are 187 clinical trials related to iPSCs, with Japan leading in research and clinical applications, including trials for Parkinson's disease [10][11]. - In China, 146 clinical trial applications for stem cell new drugs were recorded by the end of 2024, with two iPSC products among the approved trials [11]. Group 6: Capital Dynamics - The Chinese government has introduced multiple supportive policies for the cell therapy industry, including the inclusion of cell therapy drugs in the encouraged industry directory, which has led to significant investments in the sector [12]. - Since 2025, there have been 12 financing cases in the domestic stem cell therapy field, amounting to 630 million RMB, primarily in early to mid-stage investments [12][13].