Core Insights - The article discusses the launch of the LangTaoSha Preprint Server, a collaborative open science platform aimed at enhancing academic communication in the life sciences field [3][4]. - The platform is established by Shenzhen Medical Academy, Shenzhen Bay Laboratory, Tsinghua University, Westlake University, and other leading institutions, focusing on rapid dissemination of research findings prior to formal peer review [3]. - The introduction of blockchain technology ensures the integrity and traceability of scientific records by generating unique, immutable timestamps and encrypted certificates for each published paper [3]. Group 1: Platform Overview - The LangTaoSha Preprint Server officially launched in November 2025, providing a reliable and efficient environment for researchers [3]. - The platform has already published 11 research papers, including two from the team led by Academician Yan Ning [4]. - The platform aims to integrate AI-driven tools to streamline manuscript screening processes and improve manuscript quality [3]. Group 2: Research Highlights - The paper titled "Open-state structure of veratridine-activated human Nav1.7 reveals the molecular choreography of fast inactivation" focuses on capturing the open-state structure of the sodium channel Nav1.7 using veratridine [5][8]. - The research team identified two complexes of Nav1.7 with veratridine, revealing insights into the dual-mode regulatory mechanism of veratridine on sodium channels [9][11]. - Another paper, "High-throughput cryo-EM characterization and automated model building of glycofibrils via CryoSeek," introduces a new strategy combining cryo-electron microscopy with AI for discovering novel biological entities [12][13]. Group 3: Methodologies and Innovations - The CryoSeek methodology allows for high-throughput processing of cryo-EM data and automated modeling of glycan structures, establishing a workflow for reconstructing three-dimensional electron microscopy maps [14]. - The research team proposed a unified naming scheme for the fibers discovered through CryoSeek, which will aid in understanding glycan folding principles [14]. - A CryoSeek database has been created for data archiving and sharing, accommodating the large volume of structures obtained through this strategy [14].