Core Viewpoint - Evommune, Inc. shares experienced a decline due to profit-taking after a significant increase of approximately 70% following positive Phase 2a trial results for EVO301 in treating moderate-to-severe atopic dermatitis [1] Group 1: Trial Results - The Phase 2a trial of EVO301 demonstrated a 33% placebo-adjusted improvement in the Eczema Area and Severity Index (EASI) at week 12, with 23% of patients achieving a score of 0 or 1 on the Investigator's Global Assessment for Atopic Dermatitis [2] - The company plans to proceed to a Phase 2b dose-ranging trial with a subcutaneous formulation of EVO301 and is also exploring additional indications, including ulcerative colitis [2] Group 2: Analyst Insights - William Blair analysts noted that the trial results provide clear proof of concept for EVO301 in atopic dermatitis, which had previously been undervalued in Evommune's share price [3] - Analyst Matt Phipps raised the probability of success for EVO301 to 51% from 29% and increased the 2035 sales estimate to $1 billion from $760 million, suggesting that this estimate could be conservative if efficacy is shown in other diseases [4] Group 3: Stock Performance - Evommune shares were trading 5.1% below their 20-day simple moving average (SMA) and 2.7% below their 50-day SMA, indicating short-term weakness [5] - Despite recent volatility, the stock is trading 38.7% above its 20-day SMA and 45.3% above its 50-day SMA, reflecting a strong long-term trend [6] - Over the past 12 months, shares have decreased by 16.02% and are closer to their 52-week lows than highs, indicating potential challenges ahead [6] Group 4: Analyst Consensus - The stock is rated as a Strong Buy with an average price forecast of $44.17, and recent analyst actions include a Buy rating from HC Wainwright & Co. with a target raised to $65.00 [8][9] - At the time of publication, Evommune shares were down 3.62% at $27.43 [8]

Core Insights - Evommune's EVO301 shows promising results in a Phase 2a trial for moderate to severe atopic dermatitis, leading to a 75% stock price increase [1][2] - The drug demonstrated a 55% reduction in EASI scores at week 12, significantly outperforming the placebo group, which had a 22% reduction [2][3] - The company plans to initiate a Phase 2b trial with a subcutaneous formulation and explore dose optimization to enhance efficacy [4][5] Clinical Data Highlights - In the Phase 2a trial, EVO301 achieved a 55% reduction in EASI scores at week 12, compared to 22% for the placebo [2] - 23% of patients reached near-clearance levels (scores of 0 or 1) by week 12, aligning with top-tier treatments like Dupixent [3] - The trial utilized a single-dose regimen without dose optimization, indicating significant potential for improved outcomes with further adjustments [3] Future Development Plans - Evommune will start a Phase 2b trial focusing on converting the intravenous formulation to a subcutaneous one, enhancing patient compliance [4] - The company aims to optimize dosing strategies, potentially increasing dosage or frequency to maximize the drug's effectiveness [4] - Plans to accelerate the development of EVO301 for ulcerative colitis, with a concept validation trial likely starting earlier than the previously set 2026 target [5] Market Implications - The success of EVO301 validates the clinical activity of IL-18 fusion proteins, positioning Evommune favorably in the competitive landscape of chronic inflammatory diseases [5] - The drug's performance opens new possibilities for IL-18 inhibitors, addressing unmet clinical needs in various inflammatory conditions [5]

Core Insights - The trial for EVO301 demonstrated significant efficacy in treating moderate-to-severe atopic dermatitis, achieving a 33% placebo-adjusted improvement in the Eczema Area and Severity Index at week 12 [2] - The company plans to advance to a Phase 2b dose-ranging trial with a subcutaneous formulation of EVO301 and explore additional indications such as ulcerative colitis [5] Trial Data - The study involved 70 patients, with 48 receiving the active treatment and 22 receiving a placebo, over a 12-week period [1] - 23% of patients treated with EVO301 achieved a score of 0 or 1 on the Investigator's Global Assessment for Atopic Dermatitis, while none in the placebo group reached this score [3] - The trial showed a reduction in both Th2 and non-Th2 inflammatory biomarkers in atopic dermatitis [4] Safety and Tolerability - EVO301 was well tolerated, with no serious or severe adverse events reported and no treatment-related discontinuations due to adverse events [4] Technical Analysis - The stock is currently trading 5.1% below its 20-day simple moving average and 2.7% below its 50-day simple moving average, indicating short-term weakness [6] - Over the past 12 months, shares have decreased by 16.02%, reflecting a challenging year for the stock [6] - The RSI is at 44.19, indicating neutral territory, while the MACD is below its signal line, suggesting bearish pressure [7] Analyst Consensus & Recent Actions - The stock carries an Outperform Rating with an average price target of $39.17, with recent analyst actions indicating positive sentiment [8] - Evommune shares were up 42.73% at $24.25, reaching a new 52-week high [8]

Summary of Evommune's EVO301 Topline Phase 2A Results Conference Call Company Overview - **Company**: Evommune - **Product**: EVO301, a biologic targeting IL-18 for the treatment of moderate to severe atopic dermatitis - **Industry**: Biopharmaceuticals, specifically focused on chronic inflammatory diseases Key Points and Arguments Positive Clinical Results - EVO301 demonstrated unequivocally positive data in the Phase 2A proof-of-concept trial for atopic dermatitis, meeting its primary endpoint decisively [3][10] - The trial showed a Bayesian posterior probability of 99.76% that the true difference between EVO301 and placebo in the percent change from baseline at EASI was at least 8% [10] - At week 12, patients receiving EVO301 experienced a 55% mean reduction in EASI compared to 22% in the placebo group [17] - 23% of patients achieved an IGA of 0 or 1 versus 0% in the placebo group [19] Safety Profile - EVO301 was well-tolerated with no serious or severe adverse events related to the study drug [10][23] - No discontinuations due to treatment-related adverse events were reported [23] Mechanism of Action - EVO301 is designed as a long-acting fusion protein that neutralizes IL-18, which plays a key role in various immune processes and chronic inflammatory diseases [8][9] - The drug targets multiple inflammatory pathways, making it potentially more effective for heterogeneous diseases like atopic dermatitis [9][22] Future Development Plans - Evommune plans to advance EVO301 into a Phase 2B study with a subcutaneous formulation, leveraging insights from the Phase 2A study [25][26] - The Phase 2B study will likely include more doses and a longer duration to optimize efficacy [31][32] Market Context - Atopic dermatitis affects approximately 13 million Americans, with around 40% of patients not adequately controlled by existing therapies [24] - There is a significant unmet need for effective treatments, highlighting the potential market opportunity for EVO301 [24] Pipeline Expansion - Evommune is also evaluating additional indications for IL-18, including ulcerative colitis and other chronic inflammatory diseases [26][78] - The company believes that the mechanism of IL-18 modulation could lead to a broader pipeline of therapies [78] Additional Important Information - The trial was randomized, double-blind, and placebo-controlled, enrolling 70 patients across 12 sites in Australia and New Zealand [12][15] - The study design optimized for early clinical signal detection using Bayesian analysis [12] - The results from the Phase 2A trial will be presented at a future scientific conference [22] This summary encapsulates the critical findings and strategic direction of Evommune regarding EVO301, emphasizing its potential impact on the treatment landscape for atopic dermatitis and other inflammatory diseases.

Company Overview - Evommune is developing next-generation therapies for chronic inflammation, which contributes to 3 out of 5 deaths worldwide[8] - The annual direct cost of chronic inflammation is at least $90 billion[9] - Evommune completed a $173 million IPO in November 2025 and has approximately $235 million in cash and investments as of September 30, 2025[115, 116] Clinical Programs - Evommune has two Phase 2 programs: EVO756 (oral MRGPRX2 antagonist) and EVO301 (long-acting IL-18 fusion protein)[15, 117] - EVO756 is being developed for chronic spontaneous urticaria (CSU) and atopic dermatitis (AD)[20, 117] - EVO301 is being developed for atopic dermatitis and ulcerative colitis[20, 117] - Three Phase 2 data readouts are expected in 2026: EVO756 in CSU (H1 2026), EVO756 in AD (H2 2026), and EVO301 in AD (H1 2026)[20, 117] EVO756 Clinical Data - In a Phase 2 trial in chronic inducible urticaria (CIndU), both 300 mg QD and 50 mg BID doses of EVO756 demonstrated robust clinical activity, with 30% of patients achieving a complete response after just 4 weeks[47, 49] - In the CIndU trial, at week 4, patients on 300 mg QD (N=10) saw a 14 point reduction and 50 mg BID patients (N=17) saw a 15 point reduction in Mean FricTest Score (0-4)[52] EVO756 Phase 2b Trials - A Phase 2b dose-ranging trial in CSU (N = 160) is underway, with topline data expected in H1 2026[72] - A Phase 2b dose-ranging trial in AD (N = 120) is underway, with topline data expected in H2 2026[80]

Table of Contents Amendment No.1 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 EVOMMUNE, INC. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Delaware 2834 85-0742575 (Primary Standard Industrial Classification Code Number) 1841 Page Mill Road, Suite 100 Palo Alto, CA 94304 Telephone: (925) 247-4487 As filed with the U.S. Securities and Exchange Commission on October 17, 2025. Registration No. 333-290793 UNITED STATE ...

Table of Contents THE SECURITIES ACT OF 1933 EVOMMUNE, INC. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Delaware 2834 85-0742575 (Primary Standard Industrial Classification Code Number) 1841 Page Mill Road, Suite 100 Palo Alto, CA 94304 As filed with the U.S. Securities and Exchange Commission on October 9, 2025. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEME ...