Core Viewpoint - He Yuan Bio (688765.SH) is set to be available for subscription on the Sci-Tech Innovation Board, focusing on plant-based recombinant protein expression technology and product development, with a leading global platform based on rice endosperm cell bioreactor technology [1][4]. Company Overview - He Yuan Bio is recognized as a pioneer in the "rice hematopoiesis" industry, developing multiple pharmaceutical products, excipients, and research reagents [1][4]. - The company’s core product, HY1001, is a recombinant human albumin injection derived from a rice seed expression system, differing from traditional methods that extract albumin from plasma [4]. Financial Performance - The company reported revenues of 13.40 million yuan in 2022, with a year-on-year decline of 47.49%, followed by an increase of 81.08% to 24.26 million yuan in 2023, and a slight increase of 3.92% to 25.22 million yuan in 2024 [4]. - The net profit attributable to the parent company was -143.58 million yuan in 2022, -186.96 million yuan in 2023, and -151.37 million yuan in 2024, with year-on-year changes of -7.12%, -30.22%, and 19.04% respectively [4]. Market Position and Commercialization - He Yuan Bio has established a production line capable of producing 10 tons of recombinant human albumin annually and has obtained a drug production license [5]. - The company has signed distribution agreements with several pharmaceutical distributors, establishing a sales network across over 30 provinces and cities in China [5]. Research and Development Pipeline - The company has eight drugs in its research pipeline, with HY1001 being the first recombinant human albumin product approved for market in China [5]. - Two additional drugs are in Phase II clinical trials, two in Phase I, and one has been approved to commence clinical trials [5]. Future Outlook - The company anticipates a narrowing of losses, with projected revenue of 12.71 million yuan in the first half of 2025, a year-on-year increase of 33.32%, and a net profit of -81.63 million yuan, a decrease of 3.86% from the previous year [5]. - He Yuan Bio emphasizes that obtaining market approval is just the beginning of commercialization, requiring further market access, education, and promotion to achieve significant sales [6].

Core Viewpoint - He Yuan Bio (688765.SH) is set to be listed on the Sci-Tech Innovation Board, focusing on plant-based recombinant protein expression technology and product development, with a leading global plant bioreactor technology platform [1][4]. Company Overview - He Yuan Bio is recognized as a pioneer in the "rice hematopoiesis" industry, developing multiple pharmaceutical products using a rice endosperm cell bioreactor expression system [1][4]. - The company has launched its core product, HY1001, a recombinant human albumin injection derived from rice, which received approval from the National Medical Products Administration in July 2023 [4][6]. Financial Performance - The company reported revenues of 13.40 million yuan in 2022, with a year-on-year decline of 47.49%, followed by an increase of 81.08% to 24.26 million yuan in 2023, and a slight increase of 3.92% to 25.22 million yuan projected for 2024 [5]. - The net profit attributable to the parent company showed losses of 143.58 million yuan in 2022, 186.96 million yuan in 2023, and a projected loss of 151.37 million yuan in 2024, with a year-on-year decline of 7.12%, 30.22%, and an increase of 19.04% respectively [5]. Market Position and Competition - He Yuan Bio is the first company to pass the registration process under the fifth set of standards for the Sci-Tech Innovation Board and is the first new issuance in the Sci-Tech Growth Layer [5]. - The company has established a sales network across over 30 provinces and cities in China, having signed distribution agreements with major pharmaceutical distributors [5][6]. - He Yuan Bio has eight drug candidates in its pipeline, with two in Phase II clinical trials and two in Phase I trials, alongside one drug approved for clinical trials [6]. Investment and Funding - The company plans to invest 19.09 billion yuan in the construction of a plant-based recombinant human serum albumin industrialization base, 7.94 billion yuan in new drug research and development, and 8.00 billion yuan to supplement working capital [3][5].

Group 1 - The China Securities Regulatory Commission (CSRC) approved Wuhan Heyuan Biotechnology Co., Ltd.'s initial public offering (IPO) on the Sci-Tech Innovation Board, with plans to raise 2.4 billion yuan [3] - Heyuan Biotechnology, established in 2016, has a leading global plant bioreactor technology platform, and its core product HY1001 has completed Phase III clinical trials, demonstrating good safety and efficacy [4] - The National Medical Products Administration (NMPA) approved the listing of Heyuan's recombinant human albumin injection (HY1001), making it the first approved recombinant human serum albumin product in China for treating liver cirrhosis with low albumin levels [4] Group 2 - Shenzhen Beixin Life Technology Co., Ltd.'s IPO application was also approved by the Shanghai Stock Exchange's listing committee on July 18 [5] - Founded in 2015, Beixin Life focuses on developing innovative solutions for cardiovascular disease diagnosis and treatment, with its core products including the first domestically approved 60MHz high-speed IVUS diagnostic system and the first domestic FFR measurement system [6] - Beixin Life has launched 11 products to the market and has 6 products under development, covering five categories: IVUS systems, FFR systems, vascular access products, shockwave balloon therapy systems, and electrophysiological solutions [6]