Investment Rating - The report maintains an investment rating of "Outperform" [6] Core Insights - The report highlights the potential of small nucleic acid drugs in weight loss applications, validated by Arrowhead Pharmaceuticals' recent data on INHBE and ALK7 targeted siRNA drugs [3][28] - The new drug sector has shown significant price movements, with notable gains from companies like Frontline Bio (+55.96%) and Shengnuo Pharma (+27.25%) during the week of January 5 to January 11, 2026 [1][16] - There are multiple catalysts expected in the sector, including academic conferences and data releases, which could drive further interest in specific companies [2] Weekly New Drug Market Review - From January 5 to January 11, 2026, the top five gainers in the new drug sector were Frontline Bio (+55.96%), Shengnuo Pharma (+27.25%), Rongchang Bio (+24.64%), Yifang Bio (+22.61%), and Zhixiang Jintai (+19.09%) [1][16] - The top five decliners included Jiahe Bio (-10.69%), Junsheng Tai (-10.56%), Beihai Kangcheng (-5.51%), Yongtai Bio (-3.15%), and Laikai Pharma (-1.84%) [1][16] Weekly Focus on Recommended Stocks - Companies with high overseas growth potential certified by MNCs include Sanofi Pharma, Lianbang Pharma, and Kelun Biotech [2] - Companies with overseas data catalysts include Betta Pharma, Hutchison China MediTech, and Yingen Bio [2] - Potential heavyweights for overseas licensing include Fuhong Hanlin, CSPC Pharmaceutical Group, and Yifang Bio [2] - New innovative drug technology breakthroughs are expected in areas such as small nucleic acids, in vivo CAR-T, fat loss and muscle gain, autoimmune CAR-T/bispecific antibodies, and gene therapy [2] New Drug Industry Key Analysis - Arrowhead Pharmaceuticals has disclosed early weight loss data for its INHBE-targeted siRNA drug, further validating the application potential of small nucleic acid drugs in weight loss [3][28] - Domestic companies are actively developing INHBE-targeted siRNA drugs, including major players like Dairui Bio, Shengyin Bio, and Bowe Pharmaceutical [3][34] - The ALK7-targeted siRNA drug ARO-ALK7 has shown promising results, with a significant reduction in visceral fat observed in clinical trials [40][41] New Drug Approval and Acceptance Status - This week, 8 new drug or new indication applications were approved in China, while 20 applications were accepted [4][43] - The approved drugs include various formulations and indications, such as the injection of human thyroid-stimulating hormone beta and the injection of relaflufin alpha [44] New Drug Clinical Application Approval and Acceptance Status - A total of 47 new drug clinical applications were approved this week, with 46 applications accepted [10][48]