以下文章来源于AGI接口 ，作者陈广晶 AGI接口 . AI卷起的财富风暴。 出品 | 虎嗅科技医疗组 作者 | 陈广晶 编辑 | 苗正卿 头图 | AI生成 制药界也为AI疯狂了？ 6月13日，一份潜在价值超50亿美元的AI制药大单，在业界刷屏了。这也是继续新药领域频繁BD （ 商务拓展，指药企通过针对新药的合作、交易、并购等实现业务增长——虎嗅注 ）之后， 跨 国药企给国产新药产业打的又一剂强心针。 根据石药集团的公告，该集团将使用其AI药物发现平台，针对阿斯利康选定的多个靶点，找到治 疗多个适应症的有潜力的小分子口服药的候选药物。其中包括一种用于免疫疾病的疗法。 对于这些候选药物，阿斯利康有优先选择权，可获得全球范围内开发、生产和商业化的独家授 权。 上述交易中，阿斯利康给出的首付款就有1.1亿美元，后续潜在里程碑付款最高可达16.2亿美元， 销售里程碑付款可高达36亿美元，此外还可能有基于产品年净销售额的销售提成。总价值约53.3 亿美元，折合人民币超过了380亿元。 虽然在license-out（ 对外许可 ）的战绩中，这一交易算不上新高，但在AI+制药领域却是刷新记 录的。 作为行业里有名的"AI ...

Core Insights - A significant AI pharmaceutical deal valued at over $5 billion has emerged, marking a strong endorsement for China's domestic drug industry from multinational pharmaceutical companies [1][2] - AstraZeneca has partnered with Shijiazhuang Pharmaceutical Group to utilize its AI drug discovery platform for developing potential small molecule oral drugs targeting multiple indications, including therapies for immune diseases [1][5] - The deal includes an upfront payment of $110 million, with potential milestone payments reaching up to $1.62 billion, and sales milestone payments up to $3.6 billion, totaling approximately $5.33 billion [1][2] Industry Trends - AstraZeneca has become a leader in AI collaborations, having established 27 partnerships in 2023, although typical upfront payments in the industry have been below $50 million [2][3] - The pharmaceutical industry is increasingly leveraging AI to enhance drug discovery efficiency, with AI applications projected to save companies approximately $54 billion annually in R&D costs [6][7] - The urgency for pharmaceutical companies to find breakthrough drugs is heightened as traditional drug discovery methods face challenges, leading to a shift towards AI-driven approaches [14][20] Company Performance - AstraZeneca has shown remarkable improvement in drug development efficiency, with a success rate of 31% for new drug candidates from 2016 to 2020, compared to just 4% from 2005 to 2010 [9][21] - The company reported global revenues of $45 billion in 2023, doubling its revenue from a decade ago, with projections to exceed $54 billion in 2024 [10][21] - AstraZeneca's stock performance has been under scrutiny, as despite strong operational results, the CEO faced a salary reduction due to stock price performance not meeting expectations [22][24] Future Outlook - The collaboration with Shijiazhuang Pharmaceutical Group is part of AstraZeneca's broader strategy to identify potential blockbuster drugs that can significantly impact its market valuation [20][22] - The pharmaceutical industry is expected to continue investing heavily in AI technologies to improve drug discovery and clinical trial processes, aiming to reduce failure rates and accelerate time-to-market for new therapies [18][19] - AstraZeneca's ongoing partnerships and investments in AI are critical for maintaining competitive advantage in a rapidly evolving pharmaceutical landscape [15][16]