Core Viewpoint - Lijun Group's 2025 interim report shows stable revenue performance with a slight decrease in total revenue but an increase in net profit, indicating resilience in its business operations and growth potential in specific segments [1][2]. Revenue Performance - In the first half of 2025, Lijun Group achieved revenue of 6.272 billion yuan, a year-on-year decrease of 0.17%, while net profit attributable to shareholders reached 1.281 billion yuan, a year-on-year increase of 9.40% [1]. - The second quarter revenue was 3.091 billion yuan, reflecting a year-on-year growth of 1.71%, with net profit attributable to shareholders at 644 million yuan, up 14.42% year-on-year [1]. Business Segment Analysis - Chemical preparations generated revenue of 3.270 billion yuan (up 1.43% year-on-year), while traditional Chinese medicine revenue was 799 million yuan (up 7.31% year-on-year). However, raw material drug revenue decreased to 1.662 billion yuan (down 5.65% year-on-year) [2]. - Growth in chemical preparations was driven by gastrointestinal products (1.351 billion yuan, up 3.87%) and psychiatric products (317 million yuan, up 6.89%). The traditional Chinese medicine segment benefited from increased penetration in pharmacy channels [2]. Product Development and Pipeline - Lijun Group has a rich R&D pipeline, with products like Aripiprazole microspheres and progesterone injection approved for market launch. Ongoing clinical trials include an anti-IL-17A/F antibody for psoriasis and a gout medication showing promising results [3]. - The company employs a self-research and business development model to rapidly enhance its product pipeline, with products in the autoimmune and gastrointestinal fields expected to enter a harvest phase soon [3]. Future Outlook - The company maintains a "buy" rating, projecting revenues of 12.343 billion yuan, 12.926 billion yuan, and 13.573 billion yuan for 2025-2027, with respective year-on-year growth rates of 4.50%, 4.72%, and 5.00% [4]. - Net profit forecasts for the same period are 2.272 billion yuan, 2.457 billion yuan, and 2.646 billion yuan, with year-on-year growth rates of 10.23%, 8.16%, and 7.69% [4]. Investment Thesis - Given Lijun Group's strong sales capabilities and its strategy of rapidly supplementing its product pipeline through self-research and business development, the "buy" rating is maintained [5].

Group 1: Key Research Projects - LZM012 targets IL-17A/F for moderate to severe psoriasis and ankylosing spondylitis, showing superior efficacy compared to control in Phase III trials, with PASI100 as the primary endpoint [2][5] - LZHN2408 for gout with hyperuricemia has received clinical approval, currently in Phase I trials, focusing on safety and efficacy [2] - H001, an anticoagulant for post-operative venous thromboembolism, has completed Phase II trials, showing comparable efficacy to enoxaparin with lower bleeding risk [3][7] - NS-041, a new generation KCNQ2/3 activator for epilepsy, has completed Phase I and is moving to Phase II, with no similar drugs on the market [3] - SG1001 for invasive fungal infections has completed Phase I trials, addressing drug resistance issues [3] - JP-1366, a P-CAB for gastrointestinal disorders, has completed Phase III trials and is preparing for market application [3] Group 2: Market Potential and Commercialization - The global market for psoriasis treatments is significant, with ustekinumab sales exceeding $6 billion in 2022, and UCB's bimekizumab projected to grow from $150 million in 2023 to over $600 million in 2024 [6][7] - LZM012 is expected to receive approval by mid-2027, aligning with the annual medical insurance negotiations [7] Group 3: Safety and Efficacy Data - LZM012's 52-week safety data shows a lower adverse reaction rate compared to ustekinumab, with no additional safety concerns identified [5] - H001's Phase I results indicate good safety profiles with no gastrointestinal bleeding, and preliminary data shows its anticoagulant effect is comparable to enoxaparin [7]

R&D Progress and Key Projects - LZM012, targeting IL-17A/F, is the first IL-17A/F inhibitor to complete Phase III clinical trials in China, showing a PASI100 response rate of 49.5%, outperforming the control group at 40.2% [6][7] - LZHN2408, for gout with hyperuricemia, has received clinical approval and is currently in Phase I trials, demonstrating safety and efficacy in preclinical studies [3][8] - H001, an anticoagulant for post-surgical venous thromboembolism, has completed patient enrollment in Phase II trials, showing comparable efficacy to enoxaparin with lower bleeding risks [3][4] New Drug Development - NS-041, a new generation KCNQ2/3 activator for epilepsy, has completed Phase I trials and is set to enroll over 280 patients in Phase II, with no similar drugs currently on the market [4] - SG1001, targeting invasive fungal infections, has completed Phase I trials and is expected to address drug resistance issues [5] - JP-1366, a P-CAB product, has completed Phase III trials and will soon submit for market approval, filling a gap in the domestic P-CAB injection market [5] Strategic Initiatives - The company plans to introduce 6 new drug projects in 2024, with 5 being innovative drugs, focusing on consolidating its leading position in gastrointestinal and neurological fields [9][10] - The acquisition of Vietnam's IMP Company aims to enhance market presence in Southeast Asia, leveraging local production capabilities and distribution networks [11] Clinical Data and Market Potential - LZM012's Phase III data indicates a low adverse reaction rate compared to the control drug, with ongoing evaluations for additional indications and potential overseas licensing [7][10] - The small RNA technology platform is being developed to enhance drug delivery systems, with a focus on the gout project as a leading initiative [8] Efficiency Improvements - The company has reformed its R&D system to improve efficiency through strategic project management and resource allocation, focusing on high-quality advancements in key therapeutic areas [11]

R&D Strategy and Product Pipeline - The company has initiated a comprehensive review of its R&D strategy starting in 2024, focusing on clear and defined strategic lines around disease areas and technology platforms [2][3]. - In the gastrointestinal field, the company is expanding its product lineup with P-CAB tablets and injectables, with P-CAB tablets currently in Phase III clinical trials [3]. - The reproductive health sector has a complete product cycle from ovulation induction to luteal support, with a key product, recombinant human follicle-stimulating hormone injection, reported in January 2023 and expected to enhance the product pipeline [3]. - In the field of mental health, the company is advancing its pipeline with innovative products like NS-041 tablets, which have completed Phase I trials and are moving into Phase II [4]. Key Product Developments - NS-041 tablets are positioned as a best-in-class product for epilepsy, showing superior selectivity and efficacy compared to similar products in development, with a patent protection until 2042 [4]. - The small nucleic acid project LZHN2408 has completed IND filing and targets gout with high patient demand, expected to receive clinical approval soon [5]. - The IL-17A/F monoclonal antibody for psoriasis has completed Phase III clinical enrollment and is expected to launch in 2025, with promising clinical data showing a 60% complete skin clearance rate at 12 weeks [6][7]. Business Development and Market Strategy - The company employs a dual strategy of self-research and business development (BD) to enhance its pipeline, focusing on projects that align with its core areas and technology platforms [9]. - The acquisition of Vietnam's IMP company aims to strengthen innovation and global market presence, leveraging IMP's established marketing network and production capabilities [12]. - The company anticipates steady growth in its traditional Chinese medicine sector, driven by products like the ginseng and astragalus injection, benefiting from policy changes [10][11]. Organizational Changes and Efficiency - The company has enhanced its operational efficiency through systematic improvements in R&D project management, optimizing processes and resource allocation [13]. - Structural adjustments have been made to ensure a stable workforce while optimizing roles, particularly in sales, to support product launches and market penetration [13].