Core Viewpoint - Gilead Sciences experienced a significant stock increase of nearly 6% following favorable Q4 results, with a notable 100% gain over the past two years, reaching an all-time high of $157 per share [1]. Q4 Results - Gilead reported Q4 sales of $7.92 billion, a 5% increase from $7.56 billion in the same quarter last year, exceeding estimates of $7.57 billion [2]. - The HIV franchise sales grew by 6%, driven by strong demand for products like Biktarvy and Descovy, while liver disease revenue rose by 17%, led by Livdelzi [2]. - Net income for the quarter was $2.2 billion, translating to an adjusted EPS of $1.86, which surpassed expectations of $1.83 despite a decline from $1.90 per share a year ago [2]. Full Year Results & Guidance - For FY25, Gilead's EPS is projected to spike by 76% to $8.15 compared to $4.62 per share in 2024, with annual sales increasing over 2% to $29.44 billion [4]. - Gilead's guidance for FY26 anticipates annual sales between $29.6 billion and $30 billion, slightly below Wall Street's estimate of $30.04 billion, but the top end of EPS guidance ($8.45-$8.85) exceeds expectations of $8.61 [5]. Valuation and Dividend - Gilead's valuation remains attractive at 17X forward earnings, which is below the S&P 500 average and the industry average of 19X [6]. - The company offers a 2.15% annual dividend yield, higher than the S&P 500's average of 1.07%, with a payout ratio of 39% [8][9]. Return on Invested Capital (ROIC) - Gilead has a return on invested capital (ROIC) of 24%, significantly higher than many biopharmaceutical companies, which typically have ROIC in the mid-teens or single digits due to high R&D investments [10]. Investment Outlook - Following the favorable Q4 results, Gilead Sciences holds a Zacks Rank 3 (Hold), presenting an intriguing option for long-term investors seeking value and income [11].

Core Viewpoint - Gilead Sciences is experiencing strong financial performance and growth potential, particularly in its HIV and liver disease segments, supported by a robust pipeline of new products and an optimistic outlook from analysts [1][2][3][4][6]. Financial Performance - Gilead's Q4 2025 earnings report showed total product sales of $7.9 billion, marking a 5% increase year-over-year [2][6]. - For the full year 2025, total sales reached $28.9 billion, reflecting a 1% increase from 2024 [2][6]. - HIV sales specifically grew by 6% year-over-year, driven by the success of the drug Biktarvy and a 47% increase in the HIV prevention portfolio [2][6]. Product Developments - The new HIV prevention injectable, Yeztugo, has surpassed coverage goals and is gaining market share [3][6]. - Gilead's pipeline includes up to 10 ongoing and potential new launches through 2027, with four commercial launches planned for 2026 [3][6]. - The liver business reported a 6% growth, attributed to the adoption of Livdelzi for primary biliary cholangitis [4][6]. - Trodelvy, an oncology product, also demonstrated positive momentum with a 6% growth in 2025, supported by favorable Phase results [4][6]. Analyst Ratings - BMO Capital has maintained an "Outperform" rating for Gilead, raising the price target from $150 to $160, indicating confidence in the company's future performance [1][6].

Core Viewpoint - Gilead Sciences, Inc. reported strong fourth-quarter results for 2025, with adjusted earnings per share (EPS) of $1.86, exceeding estimates, while total revenues of $7.9 billion also surpassed expectations, driven by growth in HIV and Liver Disease drugs [1][4][6]. Financial Performance - Adjusted EPS for Q4 2025 was $1.86, beating the Zacks Consensus Estimate of $1.83, but down from $1.90 a year ago due to higher acquired IPR&D expenses [1][6]. - Total revenues reached $7.9 billion, a 5% increase year over year, surpassing the Zacks Consensus Estimate of $7.6 billion [1][4]. - Product sales increased by 5% year over year to $7.9 billion, with HIV product sales growing 6% to $5.8 billion [4][5]. Product Sales Breakdown - Biktarvy sales rose 5% year over year to $4 billion, capturing over 52% of the U.S. HIV treatment market [5][6]. - Descovy sales surged 33% year over year to $819 million, driven by increased demand for HIV prevention [6][7]. - Liver Disease portfolio sales increased 17% to $844 million, exceeding estimates, primarily due to demand for Livdelzi [8]. - Veklury sales fell 37% to $212 million, attributed to lower COVID-19 hospitalization rates [8]. Cost and Expenses - Adjusted product gross margin was 86.8%, slightly up from 86.7% year over year [11]. - Research and development expenses remained flat at $1.6 billion, while SG&A expenses decreased to $1.7 billion from $1.9 billion [11][12]. 2025 and 2026 Guidance - For 2025, revenues rose 2% year over year to $29.4 billion, exceeding estimates, with adjusted EPS increasing to $8.15 from $4.62 in 2024 [13]. - Gilead expects 2026 product sales between $29.6 billion and $30 billion, with adjusted EPS projected in the range of $8.45-$8.85 [14][15]. Pipeline and Regulatory Updates - Positive phase III results for the investigational regimen of bictegravir and lenacapavir were reported, with a potential launch targeted for the second half of the year [16][23]. - Gilead has discontinued several studies based on recommendations from independent committees, including the phase III STAR-221 study [18][19]. Market Position and Competitive Landscape - Gilead's HIV business exceeded management's growth target, driven by strong performances from Biktarvy and Descovy, despite competitive pressures [21][22]. - The company anticipates continued competitive pressures in cell therapies and expects to face headwinds from U.S. government drug pricing agreements [24][27].

Core Insights - Gilead Sciences reported a strong performance in its HIV segment, with full-year sales reaching $20.8 billion, a 6% increase year-over-year, and fourth-quarter sales hitting a record $5.8 billion, also up 6% [1][6]. Financial Performance - Total product sales for the fourth quarter were $7.9 billion, a 5% increase year-over-year, while excluding Veklury, sales were $7.7 billion, up 7% [2]. - For the full year 2025, Gilead's total product sales were $28.9 billion, up 1% from 2024, exceeding guidance [3]. - The base business sales, excluding Veklury, were $28.0 billion, up 4% year-over-year, and would have been 8% without the impact of the Medicare Part D redesign [2][6]. HIV Business Highlights - The HIV business faced a $900 million headwind from the Part D redesign in 2025, but management indicated that excluding this impact, HIV sales grew by 10% [1]. - Biktarvy, a key treatment, generated fourth-quarter sales of $4.0 billion, up 5% year-over-year, and full-year sales of $14.3 billion, up 7% [7]. - The injectable HIV prevention product Sunlenca generated $150 million in 2025, with management forecasting about $800 million in revenue for 2026 [8][9]. Liver and Oncology Performance - Gilead's liver disease business grew 6% in 2025 to $3.2 billion, with fourth-quarter sales of $844 million, up 17% year-over-year, driven by the adoption of Livdelzi [12]. - In oncology, Trodelvy sales rose 6% in 2025 to $1.4 billion, with fourth-quarter sales of $384 million, up 8% year-over-year [13]. Future Guidance and Pipeline - For 2026, Gilead expects total product sales of $29.6 billion to $30.0 billion, with base business sales projected to grow 4% to 5% [21]. - The company plans multiple potential launches in 2026, including Trodelvy for first-line TNBC and a combination therapy for HIV [5][18]. - Management anticipates a product gross margin of about 87% and non-GAAP diluted EPS of $8.45 to $8.85 for 2026 [22]. Capital Return Strategy - Gilead returned $5.9 billion to shareholders in 2025, including $1.9 billion in share repurchases, and aims to return at least 50% of free cash flow to shareholders [24].

Financial Data and Key Metrics Changes - Full-year 2025 total product sales were $28.9 billion, up 1% from 2024, exceeding guidance due to strong demand-led HIV sales growth [34][40] - Base business revenue, excluding Veklury, was $28 billion, up nearly 4% from 2024, also exceeding guidance [34][36] - Non-GAAP diluted EPS for 2025 was $8.15, in line with guidance, reflecting lower acquired IP R&D expenses and higher revenues [38][40] Business Line Data and Key Metrics Changes - HIV business grew 6% year-over-year to $20.8 billion, driven by strong growth in Biktarvy and Descovy [35][12] - Liver business sales reached $3.2 billion, up 6% year-over-year, primarily due to Livdelzi's performance [19][36] - Oncology product Trodelvy sales increased 6% to $1.4 billion, driven by demand in metastatic breast cancer treatment [20][21] Market Data and Key Metrics Changes - HIV prevention portfolio grew 47% year-over-year, with Sunlenca achieving 90% coverage ahead of target [4][16] - Descovy sales for HIV prevention were $2.8 billion, up 31% year-over-year, reflecting increased demand [15][11] - Cell therapy sales were $1.8 billion, down 7% year-over-year, reflecting competitive pressures [22][36] Company Strategy and Development Direction - Gilead is targeting four commercial launches in 2026, including Trodelvy for first-line metastatic triple-negative breast cancer and Biclen for HIV treatment [8][24] - The company aims to maintain expense discipline while investing in new launches and M&A opportunities [9][44] - Gilead's pipeline includes up to seven potential HIV product launches through 2033, indicating a strong focus on innovation [26][27] Management Comments on Operating Environment and Future Outlook - Management expressed confidence in entering 2026 with a strong position, citing no major product LOEs until 2036 [9][44] - The company anticipates a 2% headwind to growth in 2026 due to drug pricing agreements and changes to the Affordable Care Act [42][40] - Management expects total HIV sales to grow approximately 6% in 2026, with significant contributions from Yeztugo [17][42] Other Important Information - Gilead returned $5.9 billion to shareholders in 2025, including $1.9 billion in share repurchases [43][44] - The company is committed to investing about $1 billion annually in early-stage pipeline development [44] Q&A Session Summary Question: Can you elaborate on the assumptions driving the $800 million guidance for Yeztugo? - Management highlighted strong access and coverage, with 90% of payers covering Yeztugo, and emphasized ongoing efforts to ensure patient awareness and access [46][48] Question: What type of share gains do you expect for anito-cel in the fourth-line setting? - Management expects modest contributions in 2026 post-approval, with a goal to become the market leader over time due to efficacy and safety profile [54][56] Question: Are you expecting cannibalization of Descovy PrEP sales by Yeztugo? - Management believes Descovy will continue to grow in 2026, but anticipates Yeztugo will eventually take the lead in HIV prevention [59][62]

Financial Data and Key Metrics Changes - For the full year 2025, total product sales were $28.9 billion, up 1% from 2024, exceeding guidance due to strong HIV sales growth [34][36] - Base business revenue, excluding Veklury, was $28 billion, up nearly 4% from 2024, also exceeding guidance [34][36] - Non-GAAP diluted EPS for 2025 was $8.15, in line with guidance, driven by lower R&D expenses and higher revenues [38][40] Business Line Data and Key Metrics Changes - The HIV business grew 6% year-over-year to $20.8 billion, driven by strong demand for Biktarvy and Descovy [35][12] - Liver disease sales reached $3.2 billion, up 6% year-over-year, primarily due to Livdelzi's performance [19][35] - Oncology sales from Trodelvy increased 6% to $1.4 billion, driven by demand in metastatic breast cancer treatment [20][21] Market Data and Key Metrics Changes - The HIV prevention portfolio grew 53% year-over-year, with Descovy sales up 31% and Yes2Go achieving $150 million in full-year sales [15][17] - The liver market share for Livdelzi exceeded 50% in second-line PBC, reflecting strong demand and competitive dynamics [19] - Cell therapy sales were $1.8 billion, down 7% year-over-year, impacted by competitive pressures [22][35] Company Strategy and Development Direction - The company is targeting four commercial launches in 2026, including Trodelvy for first-line metastatic triple-negative breast cancer and Biclen for HIV treatment [8][24] - Gilead aims to maintain expense discipline while investing in new product launches and M&A opportunities [9][44] - The company is well-positioned for growth with no major product losses expected until 2036, entering 2026 with a strong pipeline [9][44] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the company's strong performance and growth potential, highlighting a robust pipeline with up to 10 ongoing and potential new launches through 2027 [9][44] - The company anticipates a 2% headwind to growth in 2026 due to drug pricing agreements and changes to the Affordable Care Act [42] - Management expects total HIV sales to grow approximately 6% in 2026, with Yes2Go projected to generate $800 million in revenue [42][17] Other Important Information - The company returned $5.9 billion to shareholders in 2025, including $1.9 billion in share repurchases [43][44] - R&D expenses for 2025 were $5.7 billion, down 1% from 2024, reflecting disciplined investment in clinical programs [36][38] Q&A Session Summary Question: Can you elaborate on the assumptions driving the $800 million guidance for Yes2Go? - Management highlighted strong access with 90% payer coverage and ongoing DTC campaigns to increase awareness and drive growth [46][48] Question: What type of share gains do you expect for Anito-cel in the fourth-line setting? - Management expects modest contributions in 2026 post-approval, with a goal to become the market leader over time due to efficacy and safety profiles [54][56] Question: Are you expecting cannibalization of Descovy PrEP sales as early as this year? - Management believes both Yes2Go and Descovy will grow in 2026, with Yes2Go expected to take the lead in the long term [59][62] Question: What do you need to show out of Purpose 365 to support approval for the once-yearly injectable lenacapavir? - The study aims to demonstrate target coverage and pharmacokinetics, with potential market expansion opportunities identified [71][76]

Financial Data and Key Metrics Changes - Gilead reported total product sales of $28.9 billion for 2025, a 1% increase from 2024, exceeding guidance due to strong HIV sales growth despite a $1.1 billion headwind from Medicare Part D redesign and a $900 million decline in Veklury revenue [33][34] - The base business revenue, excluding Veklury, was $28 billion, up 4% from 2024, also surpassing guidance [33] - Non-GAAP diluted EPS for 2025 was $8.15, in line with guidance, reflecting lower R&D expenses and higher revenues [36] Business Line Data and Key Metrics Changes - The HIV business grew 6% year-over-year to $20.8 billion, driven by strong demand for Biktarvy and Descovy, with Biktarvy sales reaching $14.3 billion, up 7% [34][11] - The liver business also grew 6% to $3.2 billion, primarily due to the strong performance of Livdelzi [34][17] - Oncology product Trodelvy saw a 6% increase in sales to $1.4 billion, driven by demand in metastatic breast cancer treatment [34][18] - Cell therapy sales declined 7% year-over-year to $1.8 billion, reflecting competitive pressures [34][20] Market Data and Key Metrics Changes - The HIV prevention portfolio, including Yes2Go, grew significantly, with fourth-quarter sales of Yes2Go at $96 million and full-year sales at $150 million [13][15] - The U.S. market for HIV prevention is expanding, with Descovy achieving over 45% market share [13] - Livdelzi's market share in the U.S. for second-line primary biliary cholangitis exceeded 50% [17] Company Strategy and Development Direction - Gilead is targeting four commercial launches in 2026, including Trodelvy for first-line metastatic triple-negative breast cancer and a new daily oral combination for HIV treatment [6][22] - The company aims to maintain expense discipline while investing in new product launches and expanding its pipeline, with up to 10 ongoing and potential new launches through 2027 [7][8] - Gilead's strategy focuses on diversifying its portfolio and enhancing its clinical pipeline, which is considered the strongest in its history [6][7] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in entering 2026 with a strong position, citing no major product losses expected until 2036 and a commitment to returning capital to shareholders [8][43] - The company anticipates a 2% headwind to growth in 2026 due to drug pricing agreements and changes to the Affordable Care Act, but expects underlying growth of 6% absent these factors [41][42] - Management highlighted the importance of ongoing clinical trials and product launches in driving future growth [24][32] Other Important Information - Gilead returned $5.9 billion to shareholders in 2025, including $1.9 billion in share repurchases [42] - The company plans to invest approximately $1 billion annually in early-stage pipeline development and partnerships [43] Q&A Session Summary Question: Can you elaborate on the assumptions driving the $800 million guidance for Yes2Go? - Management highlighted strong access with 90% payer coverage and ongoing direct-to-consumer campaigns to increase awareness and drive growth [45][48] Question: What type of share gains do you expect for Anito-cel in the fourth-line setting? - Management expects modest contributions in 2026 post-launch, with a goal to become the market leader over time due to its efficacy and safety profile [52][56] Question: Are you expecting cannibalization of Descovy PrEP sales by Yes2Go? - Management anticipates that while Yes2Go will grow, Descovy will also continue to perform well in 2026, with both products benefiting from increased awareness in HIV prevention [58][60] Question: Can you discuss the profile of the long-acting 6-month treatment drug GS-3242? - Management expressed excitement about GS-3242's potential, emphasizing its differentiated profile and the importance of its combination with lenacapavir [63][66] Question: What do you need to show in the PURPOSE 365 study for lenacapavir for PrEP? - The study aims to demonstrate effective prevention through pharmacokinetics and safety, with potential market expansion opportunities if successful [69][73]

Q425 & FY25 Financial Results 1 0 D e c e m b e r 2 0 2 4 F e b r u a r y 1 0 , 2 0 2 6 Forward-Looking Statements Statements included in this document that are not historical in nature are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Gilead cautions readers that forward-looking statements are subject to certain risks and uncertainties that could cause actual results to differ materially. These risks and uncertainties include those relating to: Gilea ...

Core Insights - The fourth-quarter earnings season is ongoing, with major pharmaceutical companies set to announce their results, including AstraZeneca, Incyte, Gilead Sciences, Vertex Pharmaceuticals, and Moderna [1] Industry Overview - Several large pharmaceutical companies such as Johnson & Johnson, Lilly, AbbVie, Biogen, Merck, and Amgen reported better-than-expected fourth-quarter results, surpassing estimates for both earnings and revenues. In contrast, Novartis and Sanofi had mixed results, with earnings exceeding estimates but revenues falling short [2] - As of February 4, 40% of companies in the Medical sector, representing 73.9% of the sector's market capitalization, reported quarterly earnings. Among these, 87.5% exceeded earnings estimates, and 75% surpassed revenue estimates. Year-over-year, earnings increased by 3.3%, while revenues rose by 9.5%. Overall, fourth-quarter earnings for the Medical sector are expected to decline by 1.5%, while sales are projected to increase by 9.1% compared to the previous year [3] Company-Specific Insights AstraZeneca - AstraZeneca's performance has been mixed, with earnings beating estimates in two of the last four quarters, meeting once, and missing once, resulting in an average surprise of 3.81%. The consensus estimate for fourth-quarter sales is $15.78 billion, with earnings expected at $2.18 per share [5] - Key medicines, particularly cancer drugs and diabetes medicine, are expected to drive fourth-quarter sales, supported by strong demand trends [7] - AstraZeneca is scheduled to report its fourth-quarter and full-year 2025 results on February 10 [8] Incyte - Incyte has a mixed history of earnings surprises, beating estimates in three of the last four quarters, with an average surprise of 14.35%. The consensus estimate for fourth-quarter sales is $1.35 billion, with earnings expected at $1.94 per share [9] - Strong sales of Jakafi and expected growth in Opzelura sales are likely to contribute to revenue growth in the fourth quarter [11][12] - Incyte is also set to report its fourth-quarter and full-year 2025 earnings on February 10 [12] Gilead Sciences - Gilead Sciences has a mixed earnings surprise history, beating estimates in three of the last four quarters, with an average surprise of 7.80%. The consensus estimate for fourth-quarter sales is $7.57 billion, with earnings expected at $1.83 per share [13] - Increased sales from Biktarvy and Descovy, along with growth in the Liver Disease portfolio, are anticipated to drive top-line growth [14] - Gilead is scheduled to report its fourth-quarter and full-year 2025 results on February 10 [15] Vertex Pharmaceuticals - Vertex has a mixed earnings surprise history, beating estimates in two of the last four quarters, with an average surprise of 2.01%. The consensus estimate for fourth-quarter sales is $3.17 billion, with earnings expected at $5.07 per share [16] - Revenue growth is likely to be driven by higher sales of its cystic fibrosis medicine, Trikafta, and contributions from newer drugs [18] - Vertex is set to report its fourth-quarter and full-year 2025 results on February 12 [19] Moderna - Moderna has a strong earnings surprise history, beating estimates in all of the last four quarters, with an average surprise of 31.45%. The consensus estimate for fourth-quarter sales is $661.4 million, with expected earnings showing a loss of $2.60 per share [20] - Revenue is expected to be primarily driven by sales of COVID-19 vaccines, although demand has declined recently [22] - Moderna is scheduled to report its fourth-quarter and full-year 2025 earnings on February 13 [23]

Core Insights - Gilead Sciences (GILD) has seen a stock surge of 22% year-to-date, outperforming the broader market [1] - The company is preparing to report its fourth-quarter earnings on February 10, with growing momentum anticipated [2] Company Overview - Gilead Sciences is valued at $181.4 billion and focuses on developing medicines for serious diseases, particularly in HIV treatment and prevention [5] - The company also has significant growth potential in oncology, antiviral medicines, and next-generation cell therapy [5] Financial Performance - In Q3, Gilead's total revenue increased by 3% year-over-year (YOY) to $7.8 billion, despite a 2% decline in product sales to $7.3 billion due to reduced Covid-19-related demand for Veklury [6] - Excluding Veklury, product sales rose by 4% to $7.1 billion, indicating resilience in the core business [6] - HIV product sales increased by 4% YOY to $5.3 billion, driven by strong demand, with Biktarvy sales climbing 6% to $3.7 billion and Descovy sales surging 20% to $701 million [6] Growth Projections - Management expects the HIV franchise to grow approximately 5% YOY, an increase from prior guidance of 3%, despite challenges from U.S. Part D redesign changes [7] - The PrEP market is expanding at a rate of 14% to 15% per year, which is expected to be sustainable through 2026 [7] - Gilead's liver disease portfolio also performed well, with sales up 12% YOY to $819 million, primarily due to increased demand for Livdelzi [7]