Core Insights - Gilead Sciences, Inc. (NASDAQ:GILD) is considered one of the most undervalued stocks on NASDAQ, with a positive outlook from Moody's due to momentum in its product pipeline and recent regulatory approvals [1][2] - The introduction of Yeztugo, a twice-yearly subcutaneous injectable for HIV prevention, is a significant development for the company [1] - Gilead's liver and cancer platforms, particularly drugs like Livdelzi and Trodelvy, are positioned for future growth [2] Financial Strategy and Governance - Moody's rating update reflects concerns about governance risk but acknowledges a favorable assessment of Gilead's management and financial strategy [2] - The company has maintained conservative financial practices, focusing on bolt-on acquisitions under $5 billion [2] Company Overview - Gilead Sciences, Inc. is a U.S. biopharmaceutical company based in Foster City, California, specializing in antiviral treatments for diseases such as COVID-19, hepatitis B and C, influenza, and HIV/AIDS [3]

Core Insights - Gilead Sciences, Inc. (GILD) has demonstrated strong performance in 2025, with shares rising 26.5% year to date, significantly outperforming the industry growth of 6% [1][9] - The FDA approval of lenacapavir, branded as Yeztugo, for HIV prevention has been a pivotal event, marking it as the first twice-yearly injectable pre-exposure prophylaxis (PrEP) option in the U.S. [3][7] Gilead's HIV Portfolio - Gilead holds a leading position in the HIV treatment market, with its flagship drug Biktarvy commanding over 51% market share in the U.S. [4] - The company anticipates a 3% growth in HIV sales for 2025, up from previous expectations of flat revenue, driven by strong performances from Biktarvy and Descovy [5] - The approval of Yeztugo enhances Gilead's HIV portfolio, especially as Truvada faces generic competition [6] Oncology and Cell Therapy - Gilead's oncology portfolio includes Trodelvy, which has shown strong performance in treating metastatic triple-negative breast cancer, with plans for further approvals [11] - However, the Cell Therapy franchise, including Yescarta and Tecartus, is facing competitive pressures in the U.S. and Europe [12] - Gilead's subsidiary Kite has acquired Interius BioTherapeutics for $350 million, enhancing its capabilities in CAR T-cell therapies [13] Liver Disease Portfolio - The FDA approval of seladelpar, branded as Livdelzi, for primary biliary cholangitis (PBC) has strengthened Gilead's liver disease portfolio [14][15] Financial Performance and Estimates - Gilead's shares are currently trading at a price/earnings ratio of 13.62x forward earnings, lower than the large-cap pharma industry's average of 14.83x [16] - Earnings estimates for 2025 have increased to $8.10 from $8.02, while the estimate for 2026 has slightly decreased to $8.50 from $8.53 [17] Strategic Collaborations - Gilead has partnered with the U.S. State Department to deliver lenacapavir, indicating a commitment to expanding its HIV prevention efforts [10] - The company is also collaborating with Merck to evaluate a combination treatment for HIV, with updates expected in 2026 [20] Dividend and Cash Position - Gilead has maintained a strong cash position, with $7.1 billion in cash and equivalents as of June 30, 2025, supporting its sustainable dividend yield of 2.76% [22] - In Q2 2025, Gilead paid out $994 million in dividends and repurchased $527 million of common stock, reflecting its commitment to returning value to shareholders [21]

Company Overview - Gilead Sciences Inc. is a biopharmaceutical company focused on researching, developing, and selling innovative medicines for life-threatening diseases, including HIV/AIDS, viral hepatitis, cancer, COVID-19, and inflammation [1] Q3 2025 Earnings Expectations - Gilead is set to report its Q3 2025 earnings on November 5, with Wall Street analysts expecting an EPS of $2.15, an increase from $2.02 in the same period last year [2] - Quarterly revenue is anticipated to be $7.41 billion, a decrease from $7.54 billion a year earlier [2] Recent Performance - In Q2 2025, Gilead reported adjusted EPS of $2.01, exceeding the consensus estimate of $1.94, and revenues of $7.08 billion, surpassing the consensus of $6.94 billion [4] - The company experienced strong growth driven by products such as Biktarvy, Descovy, Trodelvy, and Livdelzi [5] Future Guidance - For the full year 2025, Gilead expects non-GAAP diluted EPS to be in the range of $7.95 to $8.25, indicating an optimistic outlook for revenue and earnings growth [5] Stock Performance and Dividends - Gilead Sciences' stock price has ranged from $78.36 to $121.82 over the past 52 weeks [3] - The company has a dividend yield of 2.73%, having paid $3.16 per share in dividends over the last 12 months [3]

Core Viewpoint - Gilead Sciences (GILD.US) reported a nearly 9% increase in stock price, reaching $120.07, following better-than-expected financial results for Q2 2025, driven by key products [1] Financial Performance - Gilead Sciences' revenue for Q2 2025 grew by 2% to $7.08 billion, surpassing market expectations of $6.98 billion [1] - Adjusted earnings per share (EPS) were reported at $2.01, exceeding the market forecast of $1.96 [1] Future Guidance - For the full year, Gilead expects product sales to range between $28.3 billion and $28.7 billion, with an upward adjustment of $100 million on both ends [1] - The company anticipates EPS to be between $5.85 and $6.15, an increase from the previous range of $5.65 to $6.05 [1] - On an adjusted basis, Gilead forecasts EPS between $7.95 and $8.25, up from the earlier estimate of $7.70 to $8.10 [1] Key Growth Drivers - The growth in revenue is attributed to the performance of products such as Biktarvy, Descovy, Trodelvy, and Livdelzi [1]

Core Insights - Gilead Sciences is focusing on executing its strategy across core franchises, particularly in HIV and oncology, while also diversifying into inflammation [2][3] - The company has developed a strategy over the past 5 to 6 years to maintain leadership in virology and expand into other therapeutic areas [3] - Gilead currently has three growing franchises: virology and HIV, oncology, and inflammation, with promising data from recent presentations at ASCO [4] Financial Position - Gilead has a strong balance sheet and robust cash flows, positioning the company well for future growth opportunities [4]

Core Insights - GSK's new drug application for linerixibat has been accepted by the FDA for review, with a decision expected on March 24, 2026 [1][7] - If approved, linerixibat could fulfill a significant unmet medical need for patients suffering from cholestatic pruritus associated with primary biliary cholangitis (PBC) [2][5] GSK's Drug Development - The NDA for linerixibat is based on positive results from the phase III GLISTEN study, which demonstrated significant improvement in cholestatic pruritus and related sleep interference compared to placebo [4][7] - Cholestatic pruritus is a common symptom of PBC, a rare autoimmune disease that can lead to liver failure [5] Competitive Landscape - Other companies are also pursuing treatments for PBC, including Gilead Sciences, which received accelerated approval for seladelpar in August 2024 [8] - Seladelpar was acquired by Gilead for $4.3 billion and is now part of their liver disease portfolio [9] - Mirum Pharmaceuticals is developing volixibat, another oral IBAT inhibitor, currently in phase IIb trials [9]

Financial Performance - Total product sales, excluding Veklury, increased by 4% year-over-year (YoY) to $6.3 billion[9, 13] - Total HIV product sales increased by 6% YoY, driven by pricing and demand, reaching $4.6 billion[9, 13] - Biktarvy sales increased by 7% YoY, reaching $3.1 billion[9, 17] - Descovy sales increased significantly by 38% YoY, reaching $586 million[9, 17] - Liver disease product sales increased by 3% YoY, reaching $758 million, driven by increased demand across PBC, HBV, and HDV products[13, 20] - Veklury sales decreased by 45% YoY to $302 million, reflecting lower COVID-19 related hospitalizations[13, 23] - Cell Therapy product sales decreased by 4% YoY to $464 million[13] Product & Pipeline Updates - Trodelvy sales decreased by 5% YoY to $293 million due to inventory dynamics and pricing[9, 13] - Livdelzi sales reached $40 million in Q125, showing continued launch momentum in PBC[9, 19] - Positive topline Phase 3 ASCENT-04 data evaluating Trodelvy + pembrolizumab in 1L PD-L1+ mTNBC[9] - Livdelzi received EU approval in February 2025 for PBC, including related pruritus[9, 38]

Core Viewpoint - Gilead Sciences, Inc. is set to report its Q1 2025 results, with sales and earnings estimates at $6.83 billion and $1.73 per share, respectively, reflecting a positive trend in earnings estimates for 2025 and 2026 [1][4]. Financial Performance - The earnings surprise history shows Gilead has consistently beaten estimates in the last four quarters, with an average surprise of 19.47% [2][3]. - The current earnings ESP for Gilead is +3.07%, and it holds a Zacks Rank of 3 (Hold) [4]. Factors Influencing Q1 Results - Gilead's HIV franchise, particularly Biktarvy and Descovy, has been a significant driver of revenue, with estimated sales of $3.2 billion and $479 million, respectively [6][8]. - The new Medicare Part D model may have negatively impacted sales due to required discounts for Medicare patients [7]. - The Liver Disease portfolio is expected to benefit from increased demand for viral hepatitis medicines, with new drug Livdelzi contributing positively [9][12]. - Sales from Cell Therapy products are anticipated to decline due to competitive pressures, with estimates at $491 million [10]. - Trodelvy is expected to show strong demand, with sales estimates of $354 million [11]. Recent Developments - Gilead's application for lenacapavir is under review in the U.S. and EU, with a target action date set for June 19, 2025 [12]. - The company has received conditional marketing authorization for seladelpar in the EU [12]. Market Performance - Gilead's shares have increased by 14.4% year-to-date, outperforming the industry and the S&P 500 [13][14]. - The current price/earnings ratio is 13.13x forward earnings, higher than its historical mean but lower than the large-cap pharma industry average [16]. Investment Thesis - Gilead's strong HIV portfolio and ongoing innovation efforts are viewed positively, although there may be slight pressure on HIV sales in 2025 [18]. - The oncology portfolio, including Trodelvy, is diversifying the business, but the Cell Therapy franchise faces competitive challenges [19]. - Strategic deals and collaborations, such as with Merck, are seen as encouraging for future growth [20].

Core Viewpoint - Gilead Sciences, Inc. (GILD) has shown strong stock performance, hitting a 52-week high and outperforming its industry and the S&P 500, driven by positive data and pipeline advancements [1][3]. Group 1: Stock Performance - GILD's stock reached a 52-week high of $119.96 on March 10 and is currently trading at $111.44 [1]. - The stock has gained 5.5% in the past month, while the industry grew by only 1.2% [1]. Group 2: HIV Franchise - Gilead maintains a leading portfolio in HIV treatments, with over 50% market share in the U.S. as of Q4 [4]. - The flagship HIV therapy, Biktarvy, continues to drive sales growth [4]. - Descovy for PrEP has over 40% market share in the U.S. [5]. - The pipeline candidate lenacapavir shows 100% efficacy for HIV prevention in cisgender women, with potential for twice-yearly administration [5][6]. Group 3: New Drug Approvals - The FDA granted accelerated approval to seladelpar for primary biliary cholangitis (PBC), enhancing Gilead's liver disease portfolio [9][10]. - Gilead's acquisition of CymaBay Therapeutics for $4.3 billion adds seladelpar to its pipeline [10]. Group 4: Strategic Partnerships - Gilead formed a strategic partnership with LEO Pharma to enhance its inflammation research portfolio [11]. - A collaboration with Terray Therapeutics aims to develop novel small-molecule therapies [11]. Group 5: Oncology Portfolio - The breast cancer drug Trodelvy has performed well, receiving Breakthrough Therapy Designation for small cell lung cancer [12]. - However, setbacks occurred with late-stage studies for Trodelvy in urothelial cancer and non-small cell lung cancer [13]. Group 6: Cell Therapy Challenges - Gilead's Cell Therapy franchise, including Yescarta and Tecartus, faces competitive pressures expected to continue into 2025 [14]. Group 7: Financial Outlook - GILD's shares trade at a price/earnings ratio of 14.01x forward earnings, lower than the industry average of 16.60x [15]. - Earnings estimates for 2025 and 2026 have increased, indicating positive revisions [16]. - The company has a strong cash position of $10 billion as of December 31, 2024, supporting a sustainable dividend yield of 2.84% [20].