Core Viewpoint - Adolescent obesity is a global public health crisis with rising prevalence, leading to increased risks of cardiovascular and metabolic diseases, as well as cognitive impairments [2] Group 1: Research and Development - A research team from Shanghai Jiao Tong University and other institutions developed the world's first VR-based exercise intervention system, REVERIE, aimed at overweight adolescents [4][8] - The REVERIE system utilizes deep reinforcement learning and a Transformer-based virtual coach to provide safe, effective, and empathetic exercise guidance [4][8] Group 2: Study Design and Methodology - The study included a randomized controlled trial with 227 overweight adolescents, comparing outcomes between VR exercise, real-world exercise, and a control group [11] - Participants were assigned to different groups, including VR and real-world sports, with all groups receiving uniform dietary management over an eight-week intervention [11] Group 3: Results and Findings - After eight weeks, the VR exercise group lost an average of 4.28 kg of body fat, while the real-world exercise group lost 5.06 kg, showing comparable results [13] - Both VR and real-world exercise groups showed improvements in liver enzyme levels, LDL cholesterol, physical fitness, mental health, and exercise willingness [13] - VR exercise demonstrated superior cognitive function enhancement compared to real-world exercise, supported by fMRI findings indicating increased neural efficiency and plasticity [14] Group 4: Safety and Implications - The injury rate in the VR exercise group was 7.69%, lower than the 13.48% in the real-world exercise group, with no severe adverse events reported [15] - The REVERIE system is positioned as a promising solution for addressing adolescent obesity and promoting overall health improvements beyond weight loss [16][17]