Financial Data and Key Metrics Changes - The electrophysiology (EP) business has experienced significant growth, with FARAPULSE driving growth at approximately twice the market rate since its introduction in the EU in 2021 [2][4] - The U.S. market penetration for FARAPULSE has quickly surpassed 50%, indicating strong adoption and market presence [4][5] Business Line Data and Key Metrics Changes - The FARAPULSE ecosystem, including FARAWAVE catheter and Opal mapping system, has been pivotal in driving success across global markets [2][3] - The Watchman franchise is projected to be a long-term growth engine for the company, with expectations of over 20% growth depending on the outcomes of OPTION and CHAMPION trials [14][17] Market Data and Key Metrics Changes - The global electrophysiology market is valued at $13 billion, with $9 billion attributed to atrial fibrillation (AF) and $4 billion to other indications [9] - The renal denervation market is being re-evaluated, with hypertension being a common condition affecting one in four adult Americans, presenting a significant opportunity for device-based therapies [38] Company Strategy and Development Direction - The company is focused on expanding its leadership in the electrophysiology market while exploring adjacent markets such as diabetes [9][10] - There is a strategic emphasis on category leadership across various medical technology segments, including interventional cardiology and structural heart [62][63] Management's Comments on Operating Environment and Future Outlook - Management acknowledges the competitive landscape in cardiology, emphasizing the importance of understanding competition and focusing on their ecosystem of products [10][12] - The company is preparing for a shift of inpatient procedures to outpatient settings, aligning with CMS goals to enhance accessibility [47][48] Other Important Information - The company is investing in artificial intelligence to enhance product development and operational efficiency, with applications in imaging and electrophysiology [59][61] - The upcoming CHAMPION trial is expected to significantly expand the eligible patient population for the Watchman device, potentially tripling its total addressable market to $6 billion by 2030 [17][18] Q&A Session Summary Question: What is the growth outlook for the Watchman franchise? - The Watchman franchise is expected to grow over 20% long-term, contingent on positive outcomes from the OPTION and CHAMPION trials [14][17] Question: How does the company view the competitive landscape in electrophysiology? - The company recognizes the competitive nature of the market but believes it has a strong understanding of upcoming competition and is focused on its product ecosystem [10][12] Question: What is the timeline for the Seismic device and clinical data? - The Seismic device is currently enrolling in the Fracture ID study, with completion anticipated in Q1 2026 and a commercial launch expected in the first half of 2027 [30][31] Question: How does the company plan to address the access issues in renal denervation? - The company plans to focus on educating both physicians and patients about the therapy, which is crucial for market development [45][46] Question: What are the expectations for the CRM market? - The CRM market is currently the lowest growth area for the company, but a complete revamp of the CRM portfolio is underway, aiming for at or above market growth [50][52]

Financial Data and Key Metrics Changes - The company reported strong growth in the electrophysiology (EP) business, with growth rates approximately double the market average, driven by the FARAPULSE ecosystem [2][5] - The approval of persistent atrial fibrillation (AF) in the U.S. is expected to further enhance market penetration [5] Business Line Data and Key Metrics Changes - The FARAPULSE product line has seen significant adoption, particularly in the U.S. where penetration quickly surpassed 50% [4] - The Watchman franchise is projected to grow at over 20% annually, contingent on positive outcomes from the OPTION and CHAMPION trials [13][17] Market Data and Key Metrics Changes - The global electrophysiology market is valued at $13 billion, with $9 billion attributed to AF and $4 billion to other indications [9] - The renal denervation market is being revisited due to evolving clinical data and the high prevalence of hypertension, with one in four adult Americans affected [37] Company Strategy and Development Direction - The company aims to maintain category leadership across various medical device segments, including interventional cardiology and electrophysiology [67] - There is a focus on expanding the FARAPULSE ecosystem and entering adjacent markets, with a strong emphasis on innovation and product development [1][9] Management's Comments on Operating Environment and Future Outlook - Management acknowledges a highly competitive landscape in cardiology but expresses confidence in their understanding of upcoming competition and their strategic positioning [10][12] - The company is preparing for a shift of inpatient procedures to outpatient settings, aligning their product ecosystem accordingly [48][49] Other Important Information - The company is actively investing in artificial intelligence to enhance product development and operational efficiency [61][64] - The upcoming CHAMPION trial is expected to significantly impact the Watchman market, potentially expanding the eligible patient population to approximately 20 million globally [17] Q&A Session Summary Question: What is the long-term growth outlook for the Watchman franchise? - The Watchman franchise is expected to grow over 20% annually, depending on the outcomes of the OPTION and CHAMPION trials [13][17] Question: How does the company view the competitive landscape in electrophysiology? - The company recognizes the competitive nature of the market but believes their unique product offerings and ecosystem will maintain their leadership position [10][12] Question: What is the timeline for the Seismic device in interventional cardiology? - The Seismic device is currently enrolling in the Fracture ID study, with a commercial launch anticipated in the first half of 2027 [30]