Total 2Q 2025 net product revenue of $150.0 million, representing growth of 72% year-over-year and 24% sequentially AUVELITY® 2Q 2025 net product sales of $119.6 million, representing growth of 84% year-over-year and 24% sequentially SUNOSI® 2Q 2025 net product revenue of $30.0 million, representing growth of 35% year-over-year and 19% sequentially SYMBRAVO® launched June 10th, with 2Q 2025 net product sales of $0.4 million AUVELITY® market access expanded by 28 million new covered lives in the commercial c ...

Core Insights - Axsome Therapeutics, Inc. is presenting seven studies at the SLEEP 2025 conference, focusing on AXS-12 and solriamfetol, which are aimed at treating central nervous system disorders [1] Group 1: AXS-12 Presentations - AXS-12 is being evaluated in a Phase 3 open-label extension and randomized-withdrawal trial for narcolepsy, with topline results presented by Dr. Richard Bogan [2] - The impact of AXS-12 on symptom severity and functional impairment in narcolepsy is being discussed, with results from the Phase 3 SYMPHONY trial presented by Dr. Michael Thorpy [2] - A subgroup analysis from the CRESCENDO survey highlights residual symptom burden in patients with narcolepsy who are satisfied with treatment, also presented by Dr. Michael Thorpy [2] Group 2: Solriamfetol Presentations - The effects of solriamfetol on neuropsychological outcomes in patients with obstructive sleep apnea are being presented in the real-world SURWEY study by Dr. Yaroslav Winter [3] - Real-world usage of solriamfetol for excessive daytime sleepiness in patients with obstructive sleep apnea in the U.S. is being discussed, led by Dr. Yang Zhao [3] Group 3: Product Information - AXS-12 (reboxetine) is a selective norepinephrine reuptake inhibitor under development for narcolepsy, with FDA Orphan Drug Designation granted [4][5] - Solriamfetol is a dopamine and norepinephrine reuptake inhibitor being developed for multiple conditions, including ADHD and excessive sleepiness associated with shift work disorder [6] Group 4: Company Overview - Axsome Therapeutics is focused on developing innovative treatments for CNS conditions, with a portfolio that includes FDA-approved therapies for major depressive disorder and excessive daytime sleepiness [7]

Core Insights - Axsome Therapeutics, Inc. is presenting three innovative neuroscience programs at the ASCP 2025 Annual Meeting, focusing on treatments for central nervous system disorders [1][22] Group 1: AUVELITY - AUVELITY is an oral NMDA receptor antagonist approved for treating major depressive disorder (MDD) in adults, containing dextromethorphan (45 mg) and bupropion (105 mg) [3][4] - The mechanism of action for AUVELITY in treating depression is not fully understood, but it has received Breakthrough Therapy designation from the FDA for MDD [3][22] - AUVELITY is not approved for use in children and is specifically indicated for MDD [4][5] Group 2: AXS-05 - AXS-05 is being studied for its efficacy and safety in treating agitation associated with Alzheimer's disease through a Phase 3 randomized-withdrawal double-blind placebo-controlled study [2][22] - The lead author for this study is Dr. Jeffrey Cummings, Vice Chair of Research at UNLV [2] Group 3: Solriamfetol - Solriamfetol is being evaluated for excessive daytime sleepiness in patients with narcolepsy and obstructive sleep apnea, particularly those reporting anxiety and depression [2][22] - The lead author for this study is Dr. Ulf Kallweit, Assistant Professor of Neurology at Witten/Herdecke University, Germany [2]