近日，江苏省药监局党组成员、药品安全总监于萌率队赴江苏启创细胞基因研究院参加"药品监管科学 全国重点实验室课题"研讨会暨"细胞制剂质量评价创新中心"揭牌仪式。 三是坚守质量底线，筑牢高质量发展根基。将技术能力建设作为核心抓手，在全力推进创新的同时，打 造覆盖药品全生命周期的检验检测体系，让质量底线有"技"可依，严守安全底线和质量高线。 今年3月，由江苏省药品监督检验研究院牵头，与南京大学、江苏启创细胞基因工程研究院等单位联合 申报，成功获批药品监管科学全国重点实验室第三批课题"干细胞制备终点AI动态快检创新质控方法研 究"。该课题基于自研人工智能DeepSearch引擎和显微细胞功能分析仪，构建形态-功能映射模型，旨在 建立高效、低成本的干细胞质控方法，为监管与企业提供精准过程控制方案。5月，江苏省药品监督检 验研究院与南京九川科学技术有限公司、江苏启创细胞基因工程研究院等多家单位联合申报的"无透镜 数字芯片显微成像技术及生物医疗应用"项目，获评江苏省科协"2024年度江苏省行业领域十大科技进展 (生物医药领域)"。 下一步，江苏省药品监督检验研究院将以本次合作为抓手，聚焦干细胞、T细胞、细胞外囊泡等制剂的 ...

Core Viewpoint - The research published by Yale University confirms the presence of T cells in the healthy brains of mice and humans, specifically in the subfornical organ (SFO), indicating that T cells can reside in the brain under normal conditions, contrary to previous beliefs about the blood-brain barrier and immune cell isolation [3][11]. Group 1: Research Findings - The study reveals that T cells in the SFO are enriched and play a crucial role in monitoring gut and fat tissue information, which is essential for regulating feeding and behavior [3][11]. - T cells in the SFO are distinct from those in the meninges, as they express proteins like CXCR6 that allow them to remain in brain tissue and secrete immune signaling proteins such as IFNγ [8][11]. - The research indicates a relationship between dietary habits and the quantity of T cells in the brain, with high-fat diets leading to an increase in T cells in both fat tissue and the brain [8][9]. Group 2: Mechanisms of Interaction - The study demonstrates that fasting increases T cell numbers in the brain while decreasing them in fat tissue, suggesting that dietary intake can dynamically regulate T cell migration to the central nervous system [9][11]. - Antibiotic intervention to deplete gut microbiota resulted in a significant reduction of T cells in the brain, indicating that gut microbiota may influence immune cell homeostasis in the central nervous system [9][11]. - The presence of T cells in the brain is linked to feeding behavior, as T cell-deficient mice took longer to find food when hungry compared to normal mice, highlighting their role in foraging and eating behaviors [9][11].