With a market cap of $24.6 billion, Biogen Inc. (BIIB) is a global biotechnology leader specializing in therapies for neurological and neurodegenerative diseases. Its portfolio includes multiple sclerosis treatments such as Tecfidera, Vumerity, Avonex, Plegridy, and Tysabri, as well as Spinraza for spinal muscular atrophy and several biosimilars. Shares of the Cambridge, Massachusetts-based company have underperformed the broader market over the past 52 weeks. BIIB stock has risen 1.6% over this time fram ...

Core Insights - Biogen exceeded Wall Street profit estimates for Q3, driven by strong sales of multiple sclerosis treatments, but lowered its annual profit forecast due to anticipated R&D charges [1][4] Financial Performance - Biogen reported Q3 earnings of $4.81 per share, surpassing expectations of $3.88 per share [4] - Sales of multiple sclerosis drugs, including Vumerity, increased nearly 1% to $1.06 billion, exceeding the combined estimate of $950.69 million [5] - The rare disease portfolio generated $533 million in sales for the quarter, reflecting an increase of nearly 8% year-over-year [5] Strategic Initiatives - The company is actively pursuing deals to enhance its early-stage pipeline, with expectations to announce at least one or two additional research-stage deals by year-end [2] - Earlier this year, Biogen licensed Vanqua Bio's experimental drug for up to $1.06 billion, indicating a focus on expanding its treatment offerings [3] Product Developments - Biogen's Alzheimer's treatment, Leqembi, saw global sales rise over 80% in Q3 to approximately $121 million, with U.S. sales growing nearly 10% to $69 million [3] - A new weekly under-the-skin injection version of Leqembi received U.S. approval in August, providing a more convenient administration option for patients [4] Future Outlook - The company adjusted its 2025 per-share profit forecast to a range of $14.50 to $15.00, down from a previous estimate of $15.50 to $16.00 [4]

Core Insights - Biogen reported Q3 2025 adjusted EPS of $4.81, exceeding the Zacks Consensus Estimate of $3.89, with an 18% year-over-year increase [1][11] - Total revenues for the quarter reached $2.53 billion, a 3% increase year-over-year, driven by strong sales growth of new drugs [2][11] Financial Performance - Product sales amounted to $1.85 billion, up 4% year-over-year, with anti-CD20 therapeutic program revenues rising 11% to $494 million [3][11] - Contract manufacturing and royalty revenues fell 35% year-over-year to $151 million, while Alzheimer's collaboration revenues increased to $43 million from $19 million [4][5] Drug Sales and Growth - Biogen's MS revenues totaled $1.06 billion, a 1% increase on a reported basis, with Vumerity sales up 36% year-over-year to nearly $215 million [7][11] - Tecfidera sales declined 28% to $168 million, while Tysabri sales rose 6% to $432 million [8][11] - Rare disease drug Skyclarys generated $133 million in sales, a 30% increase year-over-year [12][11] Cost Management - Adjusted R&D expenses decreased 7% year-over-year to $432 million, while adjusted SG&A expenses rose 6% to $592 million [16][11] Guidance and Future Outlook - Biogen raised its sales guidance for 2025, expecting approximately flat or 1% growth in constant currency terms [17][11] - Adjusted EPS guidance was lowered from $15.50-$16.00 to $14.50-$15.00 due to anticipated costs from business development transactions [19][11] Strategic Developments - Biogen resubmitted a regulatory filing for a higher dose of Spinraza, with a decision expected by April 3, 2026 [20][21] - The company completed enrollment in late-stage studies for litifilimab, with data readouts expected in the second half of 2026 [22][11] Market Position - Despite competitive pressures on MS drugs and Spinraza, Biogen's new products are positioned to drive long-term growth [27][11] - The company aims to build a multi-franchise portfolio with significant revenue potential from key pipeline products [27][11]

Core Viewpoint - Biogen is expected to exceed expectations in its third-quarter 2025 results, with earnings estimates at $3.89 per share and sales at $2.34 billion, following a previous quarter where earnings surpassed expectations by 39.2% [1] Factors Impacting Biogen - Lower sales of multiple sclerosis (MS) drugs are anticipated, particularly due to generic competition for Tecfidera and biosimilar competition for Tysabri, but this may be offset by revenue growth from new products [2][3] - The decline in MS revenue is expected to be more pronounced in the second half of the year, especially in the ex-U.S. market due to intensified competition [3] - Sales estimates for Tecfidera are $158 million (Zacks Consensus) and $162.9 million (model estimate), while Tysabri's estimates are $370 million and $346.9 million, respectively [3] Performance of Other Drugs - Vumerity's sales are projected to rise due to increased demand, with estimates at $173 million (Zacks) and $169.6 million (model) [4] - Spinraza's sales are likely to decline, with estimates at $373 million (Zacks) and $360 million (model) [4] - Sales of Skyclarys for Friedreich's ataxia are expected to improve, driven by demand growth and geographic expansion, although U.S. growth may be tempered by Medicare discount dynamics [5][6] - Zurzuvae's sales are also expected to rise due to strong patient demand, following its EU approval in September [7] Collaboration and Revenue Streams - Revenues from contract manufacturing, royalties, and Alzheimer's collaborations are expected to increase, particularly from Leqembi, which has shown consistent sales growth [8][10] - Leqembi's sales have improved sequentially over the past four quarters, with its recent approvals in various markets contributing to this growth [10][11] Earnings Surprise History - Biogen has a history of beating earnings estimates, achieving an average surprise of 10.16% over the last four quarters, although its stock has declined by 1.9% this year compared to a 9.2% industry increase [12] Earnings Prediction Model - The earnings prediction model indicates a likely earnings beat for Biogen, supported by a positive Earnings ESP of +1.08% and a Zacks Rank of 3 [14][15]

Company Overview - Biogen Inc. is valued at a market cap of $22.1 billion and specializes in therapies for neurological, neurodegenerative, and rare diseases [1] - The company has a strong presence in neuroscience, focusing on conditions such as multiple sclerosis (MS), spinal muscular atrophy (SMA), and Alzheimer's disease [1] Earnings Forecast - Biogen is scheduled to announce its fiscal Q3 earnings for 2025 on October 30, with analysts projecting a profit of $3.94 per share, a decrease of 3.4% from $4.08 per share in the same quarter last year [2] - For the current year, analysts expect Biogen to report an EPS of $15.83, down 3.9% from $16.47 in fiscal 2024 [3] Stock Performance - Over the past 52 weeks, Biogen's shares have declined by 19.5%, underperforming the S&P 500 Index's increase of 16.3% and the Health Care Select Sector SPDR Fund's drop of 6% [4] - Following the release of Q2 2025 results, Biogen's shares climbed 1.1%, with adjusted EPS of $5.47 and revenues of $2.65 billion exceeding analyst expectations [5] Analyst Ratings - Wall Street analysts have a "Moderate Buy" rating for Biogen, with 14 recommending "Strong Buy," 1 indicating "Moderate Buy," and 19 suggesting "Hold" [6] - The mean price target for Biogen is $173.21, indicating a potential upside of 15.8% from current levels [6]

Company Overview - Biogen Inc. has a market cap of $21.8 billion and specializes in therapies for neurological and neurodegenerative diseases, including multiple sclerosis and spinal muscular atrophy treatments [1] - The company is classified as a "large-cap" stock, valued at $10 billion or more, and is advancing treatments in Alzheimer's disease and other neurological disorders through strategic collaborations and innovation [2] Stock Performance - Biogen's shares have declined 28.3% from its 52-week high of $204.18, while the stock has risen nearly 11% over the past three months, underperforming the Nasdaq Composite's 12.6% increase [3] - Year-to-date, BIIB stock is down nearly 4%, lagging behind the Nasdaq's 14.7% gain, and has decreased 25.8% over the past 52 weeks compared to the Nasdaq's over 26% return [4] Financial Results - On July 31, Biogen reported Q2 2025 adjusted EPS of $5.47 and revenues of $2.65 billion, both exceeding expectations, driven by stronger sales of MS drugs like Vumerity and Tysabri [5] - Management raised its full-year adjusted EPS guidance to $15.50 - $16, indicating a more optimistic outlook for 2025 [5] Analyst Sentiment - Despite the stock's underperformance, analysts maintain a moderately optimistic view on Biogen, with a consensus rating of "Moderate Buy" from 34 analysts and a mean price target of $170.24, representing a 16.5% premium to current levels [6]

Core Viewpoint - Alkermes reported a strong second quarter for 2025, with earnings and proprietary product sales exceeding expectations, despite a slight decline in total revenues compared to the previous year [2][3][5]. Financial Performance - Alkermes reported earnings from continuing operations of 52 cents per share, beating the Zacks Consensus Estimate of 41 cents and slightly lower than 53 cents per share from the year-ago quarter [2]. - Total revenues for the second quarter were $390.7 million, a decrease of 2.1% year over year, but significantly above the Zacks Consensus Estimate of $339 million [3]. - Sales from proprietary products grew 14% year over year to $307.2 million, surpassing management's expectations of $260-$280 million [5]. Product Sales Breakdown - Vivitrol sales increased 9% year over year to $121.7 million, exceeding the Zacks Consensus Estimate of $111 million [6]. - Aristada sales rose 18% year over year to $101.3 million, beating the Zacks Consensus Estimate of $84 million [6]. - Lybalvi generated sales of $84.3 million, up 18% year over year, also surpassing the Zacks Consensus Estimate of $79 million [7]. Revenue Sources - Alkermes' revenue sources include net sales from proprietary products and manufacturing/royalty revenues from partnered products [4]. - Manufacturing and royalty revenues decreased 35.8% year over year to $83.4 million, with specific contributions from Biogen's Vumerity and other products [7][8]. Expenses and Cash Position - Research and development expenses increased by almost 30% year over year to $77.4 million, driven by ongoing studies on pipeline candidate alixorexton [8]. - As of June 30, 2025, Alkermes had cash and cash equivalents of $1.05 billion, up from $916.2 million as of March 31, 2025 [9]. Guidance and Estimates - Alkermes reiterated its financial guidance for 2025, expecting total revenues of $1.34-$1.43 billion [10]. - The company anticipates net sales of Vivitrol to be $440-$460 million, Aristada sales to be $335-$355 million, and Lybalvi's net sales to be in the range of $320-$340 million [11]. Market Position and Trends - Estimates for Alkermes have trended downward recently, with a consensus estimate shift of -14.21% [12]. - Alkermes holds a Zacks Rank 3 (Hold), indicating an expectation of in-line returns in the coming months [14].

Core Insights - Biogen reported strong second-quarter 2025 results, with adjusted earnings per share (EPS) of $5.47, significantly exceeding the Zacks Consensus Estimate of $3.93, and a 4% year-over-year increase in earnings [1] - Total revenues for the quarter reached $2.65 billion, up 7% year over year, surpassing the Zacks Consensus Estimate of $2.32 billion [2] Revenue Breakdown - Product sales were $1.9 billion, a slight decline of 1% year over year, while revenues from anti-CD20 therapeutic programs increased by 5% to $467 million [3] - Contract manufacturing and royalty revenues surged 124% year over year to $245 million, and Alzheimer's collaboration revenues rose to $55 million from $12 million in the previous year [4][5] Performance of Key Products - Sales of Biogen's multiple sclerosis (MS) drugs totaled $1.1 billion, down 4% year over year, primarily due to generic competition for Tecfidera and biosimilar competition for Tysabri [7] - Tecfidera sales fell nearly 23% to $193.6 million, while Vumerity sales increased by around 30% to $212.2 million [8] - Spinraza sales declined 8.5% to $392.7 million, missing estimates, while rare disease drug Skyclarys generated $130.3 million, up 5.2% sequentially [12] New Product Performance - New drugs Leqembi, Skyclarys, and Zurzuvae showed strong demand and sequential sales growth, with Leqembi generating $63 million in U.S. sales, a 20% increase [5][11] - Zurzuvae recorded $46.4 million in sales, up 68% sequentially, driven by increased demand [13] Cost and Guidance Updates - Adjusted R&D expenses decreased by 13% to $394 million, while SG&A expenses rose 7% to $579 million [16] - Biogen raised its 2025 EPS outlook to $15.50-$16.00, reflecting a stronger business outlook, and expects total revenues to be flat compared to 2024 [18] Market Reaction and Future Outlook - The positive guidance and strong sales of Leqembi boosted investor confidence, leading to a more than 5% rise in pre-market trading [20] - Despite rising competitive pressure on MS drugs, new products have the potential to drive growth, although it remains uncertain if they can offset declines in existing products [21]

Core Insights - Alkermes plc reported earnings from continuing operations of 52 cents per share for Q2 2025, surpassing the Zacks Consensus Estimate of 41 cents and slightly down from 53 cents in the same quarter last year [1] - Total revenues for the second quarter were $390.7 million, a decrease of 2.1% year-over-year, primarily due to lower manufacturing and royalty revenues, but still exceeding the Zacks Consensus Estimate of $339 million [1][6] Financial Performance - Proprietary product sales increased by 14% year-over-year to $307.2 million, driven by strong demand for Vivitrol, Aristada, and Lybalvi, exceeding management's expectations of $260-$280 million [4][6] - Manufacturing and royalty revenues fell by 35.8% year-over-year to $83.4 million, negatively impacting overall revenue performance [6][8] - Research and development expenses rose by nearly 30% year-over-year to $77.4 million, attributed to higher costs related to ongoing studies for the investigational pipeline candidate, alixorexton [9] Product Sales Breakdown - Vivitrol sales grew by 9% year-over-year to $121.7 million, surpassing the Zacks Consensus Estimate of $111 million [7] - Aristada sales increased by 18% year-over-year to $101.3 million, exceeding the Zacks Consensus Estimate of $84 million [7] - Lybalvi generated sales of $84.3 million, up 18% year-over-year, also beating the Zacks Consensus Estimate of $79 million [8] Guidance and Future Outlook - Alkermes reiterated its 2025 financial guidance, expecting total revenues between $1.34 billion and $1.43 billion, with specific net sales targets for Vivitrol, Aristada, and Lybalvi [11] - The company is planning to initiate a global phase III program for alixorexton in patients with narcolepsy type 1 following positive results from the phase II Vibrance-1 study [12][14] Pipeline Development - The phase II Vibrance-1 study showed statistically significant improvements in wakefulness for patients treated with alixorexton compared to placebo [13] - Alixorexton is also being studied for narcolepsy type 2 and idiopathic hypersomnia, with data from the Vibrance-2 study expected in the fall [15][16]

Core Viewpoint - Biogen is expected to report second-quarter 2025 results on July 31, with sales and earnings estimates at $2.32 billion and $3.95 per share, respectively, following a previous earnings miss of 7.4% [1][11]. Group 1: Sales Performance - Lower sales of Biogen's multiple sclerosis (MS) drugs are anticipated, likely offset by revenue growth from new products [2]. - Sales of Tecfidera and Tysabri are projected to decline due to generic and biosimilar competition, with estimates for Tecfidera at $178.0 million and Tysabri at $373.0 million [3][4]. - Vumerity's sales are expected to rise, with estimates at $70.0 million and $181.9 million [4]. - Spinraza's sales are estimated at $397.0 million and $403.0 million, with a potential reversal in favorable shipment timing impacting second-quarter results [5]. - Skyclarys is likely to see mixed dynamics in the U.S. and global markets, with growth driven more by ex-U.S. sales [6][9]. Group 2: Collaborations and New Products - Biogen's collaboration with Sage Therapeutics for Zurzuvae involves shared profits and losses, with strong patient demand expected to continue [7]. - Alzheimer's collaboration revenues, including Biogen's share from Leqembi, are expected to rise, with Leqembi's sales improving sequentially [8][10]. Group 3: Earnings Expectations - Biogen's earnings surprise history shows a mixed performance, with a four-quarter average surprise of 8.36% [11]. - The Earnings ESP for Biogen is -0.85%, indicating a lower likelihood of an earnings beat this quarter [14].