AbbVie Conference Call Summary Company Overview - **Company**: AbbVie (NYSE: ABBV) - **Date**: February 13, 2026 - **Focus**: Discussion on drug development, particularly lutikizumab and RINVOQ for hidradenitis suppurativa (HS) and inflammatory bowel disease (IBD) Key Points Drug Development and Differentiation - **Lutikizumab and RINVOQ**: Targeting HS with a distinct mechanism involving IL-1 alpha and IL-1 beta, aiming for clinical differentiation from HUMIRA and Cosentyx [1][2] - **Clinical Data**: Phase II data shows strong efficacy in both biologic-experienced and naive patients, indicating potential for differentiation in treatment outcomes [13][21] - **Combination Therapies**: AbbVie is exploring co-formulations and combinations with other assets to enhance treatment efficacy [7][9] Clinical Insights - **Neutrophil Role in HS**: Lutikizumab's bispecific approach targets both IL-1 alpha and beta, which play crucial roles in HS pathology [11][43] - **Efficacy Expectations**: Conventional wisdom suggests biologic-naive patients may show higher efficacy, but AbbVie has observed clinically meaningful effects in TNF-failure populations [17][21] Competitive Landscape - **Other Compounds**: AbbVie is aware of competitors like Sanofi's OX40 bispecific and their implications in HS treatment, particularly regarding immunosuppression risks [23][28] - **Immunogenicity Concerns**: Challenges with anti-TNF bispecifics have been noted, leading AbbVie to focus on novel mechanisms rather than traditional anti-TNFs [34][36] IBD Development - **SKYRIZI and Combinations**: AbbVie is excited about the potential of SKYRIZI in IBD, particularly with combinations involving lutikizumab and TL1A-directed treatments [45][49] - **TREM1 Mechanism**: TREM1 is being evaluated as a novel mechanism for IBD, with potential applications in other fibrotic diseases [60][78] Future Directions - **Biomarker Research**: AbbVie is investigating biomarkers to enhance individualized treatment approaches in IBD, aiming for more targeted therapies [69][70] - **TL1A in Fibrotic Diseases**: The potential for TL1A as an anti-fibrotic agent is being explored, with interest in diseases like rheumatoid arthritis and systemic sclerosis [78][80] Oral IL-23 Development - **Next-Generation Oral Treatments**: AbbVie is developing an oral IL-23 treatment, focusing on higher potency and longer half-life to improve patient adherence compared to existing therapies [81][83] Unique Compounds - **ADC Targeting CD19**: AbbVie is excited about a unique ADC targeting CD19 with a steroid payload, which may offer rapid and durable B-cell depletion [86][91] Additional Insights - **Market Positioning**: AbbVie aims to position its products effectively in the market, leveraging data from ongoing studies to enhance treatment options for patients [68][86] - **Long-Term Strategy**: The company is focused on developing innovative therapies that address unmet medical needs in both HS and IBD, with a strong emphasis on combination therapies and novel mechanisms [56][60]

Core Thesis - Teva Pharmaceutical Industries Limited is undergoing a transformation from a debt-laden generics manufacturer to a company with a credible innovative pipeline, with Duvakitug as a key catalyst for valuation [2][5]. Company Overview - Teva develops, manufactures, markets, and distributes generic and biopharmaceutical products globally, including in the United States, Europe, and Israel [2]. - As of January 28th, Teva's share price was $33.07, with trailing and forward P/E ratios of 27.45 and 11.70 respectively [1]. Product Development - Duvakitug (TEV-'574) has shown success in Phase 2b trials for ulcerative colitis and Crohn's disease, positioning it as a significant valuation catalyst [2][5]. - The drug's mechanism targets both inflammation and fibrosis, addressing disease progression and structural damage in IBD patients [3]. Future Plans - Teva is preparing for Phase 3 trials of Duvakitug in H2 2025 and is expanding its program into two new Phase 2 indications, likely including systemic sclerosis and either atopic dermatitis or asthma [3][4]. - The strategic reach of Duvakitug is broadened by these new indications, although they face varying levels of competition [4]. Market Position and Potential - Teva's potential upside is limited by competition, particularly from Merck's tulisokibart and the need for an FDA-approved anti-fibrosis label claim [5]. - Despite these challenges, Duvakitug represents a substantial call option for Teva, with shares potentially reaching $29–31 over the next year if the drug progresses successfully [5]. Historical Context - A previous bullish thesis highlighted Teva's shift towards innovation, driven by growth from products like Austedo and Ajovy, with the stock appreciating 95.79% since coverage [6][7].

Financial Data and Key Metrics Changes - The company anticipates a greater than $5 billion commercial opportunity starting at the end of the decade and escalating into the early 2030s, particularly with the CD388 antiviral treatment for influenza [9] - The company expects modest single-digit growth for Gardasil going forward, despite challenges in the China market, which represents less than 1% of revenue [54] Business Line Data and Key Metrics Changes - CD388 shows 76% efficacy in the chosen dose for phase 3 trials, which is better than existing flu vaccines [6] - Ohtuvayre, acquired from Verona, is expected to significantly scale up the company's respiratory portfolio, with excellent feedback from customers [17][18] - Winrevair in pulmonary arterial hypertension (PAH) is meeting high expectations, with continuous positive feedback from the medical community [28][30] Market Data and Key Metrics Changes - In the U.S., approximately 110 million people are expected to be candidates for CD388 treatment, with about 85 million being high-risk or immunocompromised individuals [7][8] - The company is seeing encouraging uptake in the U.S. for Winrevair, particularly among patients on triple therapy for PAH [31] Company Strategy and Development Direction - The company is focusing on expanding its respiratory portfolio and leveraging its commercial engine to maximize the potential of newly acquired products like Ohtuvayre [17][20] - The strategy includes a strong emphasis on addressing unmet medical needs, particularly in underserved populations such as those with heart failure and pulmonary hypertension [22][24] - The company is also exploring combination therapies in immunology, aiming to broaden the application of its TL1A drug across multiple indications [67][69] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about the commercial potential of CD388, highlighting its unique position as an antiviral that provides protection regardless of influenza strain [7][9] - The company is preparing for a challenging influenza season and aims to provide effective protection for high-risk individuals [9] - Management acknowledged the need for ongoing discussions with the FDA regarding the design of phase 3 trials for various products, emphasizing the importance of regulatory guidance [24][26] Other Important Information - The company is committed to driving growth in its vaccine portfolio, with Capvaxive and influenza vaccines expected to perform well in the market [58] - The acquisition of Prometheus is seen as a strategic move to enhance the company's capabilities in treating inflammatory diseases [67] Q&A Session Summary Question: What is the expected market opportunity for CD388? - The company anticipates a greater than $5 billion commercial opportunity starting at the end of the decade, particularly for high-risk populations [9] Question: How is the feedback for Ohtuvayre? - Feedback has been excellent, and the company believes there is a huge opportunity to scale the product [17][18] Question: What are the expectations for Winrevair in PAH? - Winrevair is meeting high expectations, with positive feedback from the medical community and increasing uptake among patients [28][30] Question: How does the company plan to approach the FDA for phase 3 trials? - The company plans to consult with the FDA regarding trial design and aims to ensure that the studies are appropriately sized for critical endpoints [24][26] Question: What is the outlook for Gardasil? - The company expects modest single-digit growth for Gardasil, despite challenges in the China market [54]

Core Viewpoint - HC Wainwright upgraded Shattuck Labs Inc. from Neutral to Buy, forecasting a price of $6, driven by the potential of its lead product candidate SL-325 for inflammatory bowel disease (IBD) [1] Group 1: Product Development - Shattuck Labs has initiated dosing of the first healthy participants in the Phase 1 clinical trial for SL-325, with the single-ascending dose (SAD) portion expected to be completed by Q3 2025 [1] - Enrollment for both SAD and multiple-ascending dose (MAD) portions is anticipated to conclude in Q2 2026 [1] Group 2: Market Opportunity - Analyst Joseph Pantginis highlighted the opportunity for SL-325 to capture significant market share despite competition from later-stage programs that have established clinical proof-of-concept with the TL1A approach [2] - The TL1A/DR3 development landscape for IBD, including ulcerative colitis and Crohn's Disease, has attracted attention from major pharmaceutical companies, focusing primarily on the TL1A side [3] Group 3: Competitive Landscape - Leading late-stage TL1A programs include Merck & Co.'s tulisokibart and Roche Holdings' afimkibart, which have shown promising data, but concerns regarding durability of response and immunogenicity persist across the class [4] - Shattuck Labs aims to differentiate itself by targeting the DR3 receptor, which is expected to provide more durable inflammatory control compared to ligand-level inhibition [5][6] Group 4: Stock Performance - Following the upgrade, Shattuck Labs' stock (STTK) rose by 13.3%, reaching $2.38 [6]

Core Insights - Merck has initiated three Phase 2b trials for tulisokibart, an investigational anti-TL1A monoclonal antibody, targeting immune-mediated inflammatory diseases [1][2] - The trials aim to enroll over 640 patients globally, expanding the clinical development program for tulisokibart to six diseases [1][2] - Tulisokibart is currently also being studied in two Phase 3 trials for ulcerative colitis and Crohn's disease, along with a Phase 2 study for systemic sclerosis-associated interstitial lung disease [2] Group 1: Clinical Trials and Development - Tulisokibart is being evaluated for its safety and efficacy in hidradenitis suppurativa, radiographic axial spondyloarthritis, and rheumatoid arthritis [1][2] - The ongoing clinical trials reflect Merck's commitment to addressing immune-mediated inflammatory diseases [2][9] - The total number of diseases being investigated with tulisokibart has now reached six, indicating a broadening of its therapeutic potential [2] Group 2: Disease Overview - Hidradenitis suppurativa is a chronic inflammatory skin condition affecting 0.1% to 0.8% of the population [3] - Radiographic axial spondyloarthritis, also known as ankylosing spondylitis, affects approximately 0.1% to 1% of people globally [4] - Rheumatoid arthritis is estimated to affect 17.9 million people worldwide, representing a 13.2% increase since 1990 [5] Group 3: Mechanism and Target - Tulisokibart targets tumor necrosis factor (TNF)-like cytokine 1A (TL1A), which is associated with intestinal inflammation and fibrosis [6] - The antibody is believed to inhibit inflammatory pathways involved in inflammatory bowel disease, potentially altering disease progression [6][8]