各位上午好今天是7月2号欢迎来到摩根史丹利每周三的周期论剑的在线直播我是张蕾Rachel基础创业行业的分析师今天的话我们主要讨论三个主题一个呢是请我们金融行业的首席区然会聊一下从5月的工业数据 来看一下工业贷款的风险然后接着呢我们这个能源电池行业的分析师呃那个吕洪良会聊一下对明德时代布局人工智能领域的一些思考然后最后呢我会聊一下就是海外的这个对稀土去中国化的一些布局呃那开始之前呢我先例行读一个disclaimer请注意本次会议仅面向摩根士丹利的机构客户以及财务顾问本会议不对媒体开放如果您来自媒体的话呢敬请退出会议 同时我们看到税率确实在四月末和五月初已经见顶我们现在看来从现在的新闻看来它也不会回到这么差的一个情况 还有呢就是我们对这个EB的这个利息覆盖倍数呢也进行了分析它虽然也有比上个月呢有所恶化但总体来讲呢还是处在大部分的行业处在相当健康的区间也就是说这么短的一个放缓我们觉得不会对这个整个的这个工业体系的还本付息的能力造成大的影响尤其是如果中美贸易摩擦基本上六月份七月份回到一个正常的一个状态 同时我们也看到其实在5月份有更多的行业放缓了投资增速73.5%的行业在5月份比去年上半年放缓了投资增速这个数字一直还 ...

固生堂 20250702 摘要 固生堂作为国内领先的中医连锁医疗服务机构，已形成完整的业务闭环， 涵盖线上线下服务，线下机构占比营收 91%，医疗健康解决方案占比 99%。 公司 2024 年经调整净利润为 4 亿元，同比增长 31.4%，剔除股权激励 影响后仍保持稳步增长。市场对中药饮片集采政策存在担忧，但固生堂 可通过业务结构调整和优质优价策略应对。 AI 名中医分身是固生堂的重要创新，解决了名医资源稀缺问题，有望推 动公司业务模式从重资产向轻资产转型，提升运营质量和利润率，并带 来估值空间的提升。 国内中医市场规模预计到 2031 年将达到 1.84 万亿元，复合增速高达 18.2%，受益于人口老龄化、亚健康人群增加、传统文化认同以及政策 支持等因素驱动。 民营中医服务市场高度分散，固生堂市占率仅 0.2%，行业整合机会巨 大。政策推动连锁化、高质量中医服务发展，中药集采是关键政策，连 锁机构具备资本优势。 Q&A 固生堂在中医诊疗领域的优势和发展前景如何？ 固生堂是国内中医连锁服务的龙头企业，经营稳健，深度绑定了名中医，因此 成长底色稳固，业务空间广阔。公司通过早期融资实现了线下机构扩张和线上 平台布 ...

Dorzagliatin Overview - Dorzagliatin is a first-in-class drug with global rights, targeting the underlying cause of Type 2 Diabetes (T2D) by addressing impaired glucose homeostasis[13] - As of December 31, 2019, Hua Medicine had RMB 1.1 billion in cash[13] - The global T2D population is 453 million, with 120 million in China alone, representing a massive market opportunity[13] Clinical Trial Results - In a Phase III monotherapy trial, dorzagliatin achieved the primary endpoint, demonstrating a significant and sustainable reduction in HbA1c safely[13] - In the HMM0301 Phase III trial, the dorzagliatin-treated group showed a 1.07% HbA1c reduction from a baseline of 8.35%, compared to a 0.5% reduction from a baseline of 8.37% in the placebo group (p < 0.0001)[62] - 45.4% of patients treated with dorzagliatin achieved a target HbA1c level of 7.0% or less at 24 weeks, compared to 21.5% of patients treated with placebo (p < 0.0001)[62] - Patients treated with dorzagliatin achieved a homeostasis control rate of 45.0% compared with 21.5% in the placebo group (p < 0.0001)[62] Combination Therapy - A Phase I trial (HMM0111) showed that dorzagliatin combined with sitagliptin (DPP-4 inhibitor) resulted in a 33% reduction (p<0.01) in postprandial glucose level AUEC (0-4hr)[74] - A Phase I trial (HMM0112) showed that dorzagliatin combined with empagliflozin (SGLT-2 inhibitor) resulted in a 38% reduction (p<0.0001) in postprandial glucose level AUEC (0-4hr)[79] China Market - China has the largest diabetes population globally, with approximately 125 million T2D patients[232] - The diagnosis rate in China was 50.4% in 2018 and is expected to rise to 82.2% in 2028[235] - The China anti-diabetics market is projected to grow from RMB 57.3 billion in 2018 to RMB 135.6 billion in 2025, with an expected CAGR of 11.7% from 2018 to 2028[246]

Financial Performance & Growth - IMAX reported a 40% growth in global box office market share from 2018 through 1Q25[11] - The company's 1Q25 Total Adjusted EBITDA margin was 43%[11], exceeding the FY25 guidance of 40%+[96] - IMAX projects over $12 billion in IMAX Box Office revenue for 2025[36] - The company has repurchased 19% of shares outstanding since 2020[11, 124] Network Expansion & Backlog - IMAX's global network scale includes 1,738 systems[11] across 89 countries and territories[11, 38] - The company has a contracted IMAX system backlog of 516 systems[11, 42] - International markets (excluding China) have seen over 27% network growth since pre-pandemic (year-end 2019 to March 31, 2025)[14] Content & Strategy - IMAX is increasing its connection with studios and filmmakers, expecting a record 11 Filmed For IMAX (FFI) Hollywood titles in 2025[11] - The company expects over 60 local language titles in 2025, demonstrating a 27% CAGR from 2019-2024[86, 87] - IMAX is partnering with streaming platforms to eventize and launch content[75] Financial Position - As of March 31, 2025, IMAX has $4015 million in total liquidity[117] - The company's net debt to TTM Total Adjusted EBITDA is 128x[119]

Financial Performance - GenScript Life Science revenue increased by 26.4% year-over-year[20] - Biologics CDMO revenue increased by 33.6% year-over-year, achieving historical breakeven financial goal[20] - Cell Therapy revenue increased by 101.5% year-over-year, with backlog up 108.4% year-over-year[21] - In FY21, external revenue reached $424.7 million, a 30.8% year-over-year increase[23] - Adjusted net loss of Cell Therapy was $(354.6) million in 2021 compared to $(213.3) million in 2020[23] - Adjusted net profit of Non-Cell Therapy was $50.2 million in 2021, an 18.1% year-over-year increase[23] Investments - R&D expenses for Non-Cell Therapy were $36.3 million and for Cell Therapy were $49.9 million in 2021[25], representing a 36.1% year-over-year increase in total R&D investment[24] - Capital expenditure for Cell Therapy was $47.1 million, for Biologics CDMO was $34.5 million, and for Life Science & Other was $55.8 million in 2021[28] Business Segments - Legend Biotech, a cell therapy company, received an upfront payment of $350 million and $300 million in milestone payments from Janssen[61]

Company Overview - Antengene is focused on bringing transformative medicines to patients globally, with commercialization in 6 APAC markets and 9 clinical-stage assets[12, 13] - The company raised US$21 million in Series A, US$120 million in Series B, US$97 million in Series C, and US$367 million in its Hong Kong IPO[21] - As of June 30, 2023, Antengene had RMB 1,322 million in cash and bank balances[21, 225] Pipeline Highlights - For CPI-naïve relapsed/metastatic cervical cancer, ATG-008 (Onatasertib) showed an ORR of 53.3% (16/30) and mPFS of 8.41 months[15] - In CPI-treated relapsed/metastatic cervical cancer, ATG-008 (Onatasertib) showed an ORR of 29.4% (5/17)[15] - In treatment-naïve myelofibrosis patients, Selinexor 60 mg + Ruxolitinib achieved SVR35 of 83.3% (10/12) at week 12 and 91.7% (11/12) at week 24 in efficacy evaluable patients[30] - In TP53 Wild-type Endometrial Cancer Patients, Selinexor monotherapy showed mPFS of 27.4 months compared to 5.2 months for placebo, with HR: 0.42[32] Commercial Performance & Partnerships - XPOVIO® achieved RMB 72.0 million in revenue in 2023 1H, a 33.5% increase compared to RMB 54.0 million in 2022 1H[15] - Antengene entered into a commercialization partnership with Hansoh Pharma in the Mainland of China on August 11th[15] - XPOVIO® has covered 130 DTP pharmacies across the Mainland of China and attained 46 urban-customized commercial health insurance listings (Huiminbao) covering over 55 million people[202] - From commercial launch in May 2022 to June 30th, 2023, XPOVIO® accumulated revenue of RMB 222.1 Million[202]

Antengene Pipeline Overview - Antengene is developing a diverse pipeline of oncology and autoimmune programs, including T cell engagers and other novel therapies[9, 10] - The company has partnerships and clinical collaborations to advance its programs[10] - Antengene has USD 125 million in cash and bank balances to advance pipeline development and strategic initiatives over the next 3 years[11] ATG-022 (Claudin 18.2 ADC) - ATG-022 demonstrates efficacy across all CLDN18.2 expression levels in gastric cancer, including low and ultra-low expressors[15, 23, 29] - In CLDN18.2 moderate to high expressing GC (IHC 2+ > 20%), ATG-022 showed an ORR of 40% (12/30) and a DCR of 90% (27/30)[10, 31] - In CLDN18.2 low and ultra-low expressing GC (IHC 2+ ≤ 20%), ATG-022 showed an ORR of 30% (3/10) and a DCR of 50% (5/10)[10, 31] - One patient with complete response (CR) has demonstrated durable CR for over 21 months[32] ATG-037 (CD73 Inhibitor) - The immuno-oncology (IO) market is estimated to be over USD 140 billion in 2028, including IO-resistant tumors[44] - In CPI-resistant melanoma, ATG-037 in combination with pembrolizumab showed an ORR of 36.4% (4/11) and a DCR of 100% (11/11)[10] - In CPI-resistant NSCLC, ATG-037 in combination with pembrolizumab showed an ORR of 22.2% (2/9) and a DCR of 67% (6/9)[10] AnTenGager T Cell Engager (TCE) Platform - AnTenGager is a novel second-generation "2+1" TCE platform with steric hindrance-masking technology[65] - ATG-201 (CD19 x CD3) is a TCE being developed for B cell-related autoimmune diseases, with IND targeting 2025 H2[10, 83]

诺诚健华医药有限公司 2025年一季度业绩路演 股票代码 : 9969.HK, 688428.SH 2025 年 5 月 14 日 免责声明 本材料仅供参考，不构成或构成诺诚健华医药有限公司（"公司"）或其任何控股公司或任何管辖区的子公司的证券出售或发行要约或 邀请，或购买或认购要约或邀请的邀请。本材料的任何部分都不应构成任何合同或承诺的基础，也不应作为任何与之相关的依据。 本材料中包含的信息或意见未经独立核实。对于本材料中包含的此类信息或意见的公正性、准确性、完整性或正确性，不作任何明示或 暗示的陈述或保证，也不应予以依赖。本材料中包含的信息和意见自提交之日起提供，如有更改，恕不另行通知，不会更新或以其他方 式修订以反映提交之日后可能发生的任何事态发展。本公司、其任何附属公司、董事、监事、高级管理人员、高级职员、雇员、顾问及 其各自的代表对因或依赖于这些材料中包含或呈现的任何信息或与本材料相关的任何信息而产生的任何损失不承担任何责任（过失或其 他原因）。 本材料包含反映公司截至本文所示日期对未来的当前信念和期望的声明。这些前瞻性声明基于对公司运营和业务的一些假设以及公司无 法控制的因素，存在重大风险和不确定 ...

Pushing the Frontier of Healthcare Innovation - InnoCare Introduction February 2, 2024 Disclaimer These materials are for information purposes only and do not constitute or form part of an offer or invitation to sell or issue or the solicitation of an offer or invitation to buy or subscribe for securities of InnoCare Pharma Limited (the "Company") or any of its holding company or subsidiaries in any jurisdiction. No part of these materials shall form the basis of or be relied upon in connection with any con ...

体内 CAR-T：全球竞赛已打响，关注云顶新耀和石药集团 20250701 摘要 体内 CAR-T 技术获产业催化，艾伯维 21 亿美元收购 Capstan 标志性 事件。云顶新耀和石药集团等国内企业在该领域具备稀缺性，mRNA 平 台安全性已获验证，有望成新突破点。 现有自体 CAR-T 疗法因成本高昂应用受限，全球销售额不足 45 亿美元。 体内 CAR-T 疗法旨在降低成本，提高可及性。《Nature》预测其成本 将比自体 CAR-T 低一个数量级。 基于 mRNA 的体内 CAR-T 通过 LNP 包裹 mRNA 载体，使 T 细胞表达 CAR，具有高效、安全优势，能快速表达蛋白质，且副作用可迅速恢复。 阿斯利康和艾伯维均通过收购布局该领域。 阿斯利康的 P3B3A CAR-T 技术针对多发性骨髓瘤和自身免疫疾病， CD20 CAR-T 技术针对 B 细胞淋巴瘤，已获 FDA 一期临床批准。 Interose 公司 CD2 CAR-T 技术已在澳大利亚和欧洲启动一期临床。 mRNA 平台在 CAR-T 疗法中应用前景广阔，研发周期短、成本低，可 通过替换 mRNA 序列研究不同肿瘤药物。Capston ...