On Target to Outsmart Cancer 44th Annual JP Morgan Healthcare Conference January 12, 2026 © 2026 Revolution Medicines, Inc. 2 Legal Disclaimer This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act. All statements other than statements of historical facts contained in this presentation, including statements regarding our future results of operations and financial position, business strategy, prospective products, availability of funding, abil ...

Financial Performance and Outlook - BioCryst achieved its first full year of profitability in 2025[13] - Preliminary ORLADEYO revenue for 2025 reached $601 million, with $563 million excluding European revenue[14] - The company anticipates ORLADEYO revenue between $625 million and $645 million in 2026[14] - Total revenue for 2026 is projected to be in the range of $635 million to $660 million[14] - Non-GAAP operating expenses for 2026 are expected to be between $380 million and $390 million, and $450 million to $470 million including the Astria acquisition[14] - BioCryst expects to have a cash balance of over $1 billion by 2029[37,52] Strategic Initiatives and Pipeline - BioCryst is acquiring Astria Therapeutics for approximately $700 million TEV to strengthen its HAE portfolio with navenibart[35] - ORLADEYO has a sustainable peak revenue opportunity of $1 billion, with IP protection extending into 2040[20] - The company received FDA approval for ORLADEYO pellet formulation for pediatric patients aged 2 to under 12 with HAE[13] - BCX17725 is being developed as a targeted KLK5 inhibitor for Netherton syndrome, with Phase 1 data from Part 4 expected by the end of 2026[54,69]

Business Strategy & Portfolio - Medtronic is focused on innovation to accelerate revenue and earnings growth, executing on generational growth drivers like PFA portfolio, Symplicity™, Altaviva™, and Hugo™ RAS[6] - The company intends to separate its Diabetes business, which currently accounts for $12.5 billion in revenue[9] - Medtronic is focused on the highest margin growth drivers where it has leading core competencies[8] Key Growth Opportunities - The Pulsed Field Ablation (PFA) market is estimated to be >$13 billion and growing at +25% annually[22] - Renal Denervation with Symplicity Spyral™ represents a multi-billion dollar opportunity, with 1% penetration of U.S patients equating to >$1 billion in revenue[27] - Altaviva™ Tibial Neuromodulation for Urge Urinary Incontinence presents a $1 billion revenue opportunity based on ~1% penetration of the 5M U.S patients actively seeking advanced therapies[33] - The company aims to double revenue in one of the fast-growing MedTech segments[16] Innovation & Technology - Medtronic is positioned to lead in Pulsed Field Ablation with a comprehensive product portfolio, expecting Sphere-360™ U.S Pivotal Approval by 1HFY27[22] - Symplicity Spyral™ is a breakthrough treatment for high blood pressure, targeting 18M patients in the U.S with uncontrolled hypertension[26] - Hugo™ system reimagines robotic-assisted surgery, beginning purposeful launch with urologic indication[39] Financial Performance & Strategy - Medtronic is driving innovation across its entire portfolio to achieve durable revenue acceleration in attractive MedTech markets[43] - The company is accelerating value creation through growth, disciplined operations, increased investment in R&D, and strategic M&A[46] - Medtronic expects to generate $2 billion CAS Revenue from $1 billion revenue in FY25[24]

Financial Performance & Growth - ResMed's Last Twelve Months (LTM) Q1 2026 revenue reached $5.3 billion[10] - The company's LTM Q1 2026 GAAP operating margin was 33%, and the non-GAAP operating margin was 35%[10] - Free cash flow for LTM Q1 FY26 was approximately $1.8 billion, representing a 31% year-over-year growth[16] - ResMed has a strong balance sheet with a net cash position of $715 million as of Q1 FY26[16] - Revenue grew at a Compound Annual Growth Rate (CAGR) of 12% (GAAP) and 14% (Non-GAAP) from LTM Q1 2021 to LTM Q1 2026[80] - EPS grew at a CAGR of 16% (GAAP) and 14% (Non-GAAP) from LTM Q1 2021 to LTM Q1 2026[80] Market & Strategy - ResMed targets a large and underpenetrated market, including over 1 billion people with sleep apnea and 480 million with COPD[17] - Less than 20% of the Obstructive Sleep Apnea (OSA) market is diagnosed or treated in the U.S., and less than 10% in the rest of the world[18] - ResMed invests 6% - 7% of revenue in Research and Development (R&D)[75] - The company anticipates high single-digit percentage revenue growth with earnings growth exceeding revenue growth, underpinned by its 2030 strategy[83]

Strategic Priorities - Pfizer's strategic priorities for 2026 include maximizing the value of key transactions[6] - Delivering on critical R&D milestones is another key priority for Pfizer[6] - Pfizer aims to invest to maximize post-2028 growth[6] - Scaling AI across the business is a strategic priority for Pfizer[6] Pipeline Catalysts - HYMPAVZI (marstacimab) for Hemophilia A/B with Inhibitors has been approved[7] - Regulatory decisions and data readouts are expected for over 20 pivotal study starts[8] - Pfizer is conducting 10 studies on Ultra-Long-Acting GLP-1 (PF'3944 / MET-097i)[8, 9] - Pfizer is conducting 4 studies on PD-1xVEGF (PF'4404)[8, 10] - Pfizer is conducting 2 studies on NURTEC (rimegepant)[8]

JPM Healthcare Conference 2026 Redefining Molecular Diagnostics with Single-Molecule Precision 2 Disclaimer & Forward Looking Statement 2025 Q3 Business Update This presentation contains certain "forward-looking statementsˮ within the meaning of applicable securities laws. These statements relate to future events and results of BillionToOne, Inc. (the "Company,ˮ "we,ˮ "us,ˮ or "ourˮ) and involve known and unknown risks, uncertainties and other factors that may cause the actual results, levels of activity, p ...

d JPM Healthcare Conference January 2026 2 Company highlights Disclaimer Cautionary Note Regarding Forward-Looking Statements: These presentation materials contain forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements describe future expectations, including, without limitation, estimates of and goals for future operating, financial and tax performance and results, as well as the expected execution and effect of our business str ...

This presentation should be read together with our risk factors, as disclosed in our most recently filed reports with the Australian Securities Exchange (ASX), U.S. Securities and Exchange Commission (SEC), including our Annual Report on Form 20-F filed with the SEC, or on our website. The information contained in this presentation is not intended to be an offer for subscription, invitation or recommendation with respect to shares of Telix Pharmaceuticals Limited (Telix) in any jurisdiction, including the U ...

J.P. Morgan Healthcare Conference Bob Mauch, President and Chief Executive Officer JANUARY 12, 2026 Cautionary note regarding forward-looking statements Certain of the statements contained in this presentation are "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended (the "Securities Exchange Act"). Words such as "aim," "anticipate," "believe," "can," "continue," "could," "estimate," "expec ...

BRUKER 2026 Themes After 70% Revenue Jump, our Focus is now on a Transformative Margin and EPS Jump Expanding our Leadership in Post-Genomic Discovery Solutions Project Accelerate 3.0: adding Novel Diagnostics and Automated AI-Lab Opportunities Frank H. Laukien Chairman, President & CEO Bruker Corporation (Nasdaq: BRKR) 2026 JP Morgan Healthcare Conference San Francisco, CA | January 12, 2026 INNOVATION WITH INTEGRITY BRUKER CORPORATION Safe Harbor Statement Any statements contained in this presentation whi ...