Cancer Drug Approval & Efficacy - Half of approved cancer drugs lack proof of extending survival for any approved uses [1][15] - The FDA's accelerated approval process, used heavily for cancer drugs in the last 20 years, relies on preliminary data like tumor shrinkage or progression-free survival, which may not accurately predict actual survival [13][14] - There's growing recognition that some cancer treatments may not be as helpful as expected, potentially reducing quality of life without extending lifespan [12] Pharmaceutical Industry & Financial Incentives - The pharmaceutical industry's primary motive is generating profits, potentially leading to pressure to expedite clinical trials and approve medicines on uncertain evidence [2][9] - Lower dosages of drugs could mean less revenue for pharmaceutical companies [3][25] - The median initial price of cancer drugs in the US has quadrupled over the last two decades, without a proven correlation to improved survival [26] Cost & Accessibility of Cancer Treatment - High treatment costs can significantly affect patients and their families [2][19] - Doctors in countries like India are experimenting with lower doses of cancer drugs due to affordability issues, where treatments can cost tens of thousands of dollars per year [16] - Lower dosing of just one drug could save $825 million per year in the US alone [22] - Implementing lower dosages can face pushback from manufacturers due to reduced revenue [24][25] Alternative Treatment & Research - A clinical trial in India showed that low-dose immunotherapy combined with standard treatment more than doubled the percentage of head and neck cancer patients alive after one year [20] - Using 25% less drug can achieve the same output and save significant healthcare resources [25] - Lower dose immunotherapy could allow access to life-extending drugs for a large segment of the world that currently cannot afford them, potentially saving billions of dollars and benefiting hundreds of thousands of people [21][27]

Wow. Despite ever growing challenges, >> I believe in the power of community [Music] >> that is never going to be in the cut. >> Our futures and our planet.This glacia has shrunk almost by half. >> All the materials in the world that we make, 90% of it ends up in some form of waist stream. >> Who is going to protect this.And said, why not us. [Music] [Music] Wow. [Music] [Music] >> The work that we're doing is not just about cleaning our waste.This changes the narrative. >> We turn concrete into a material ...

Geopolitical Landscape & US-China Rivalry - The Philippines is strategically important due to its location near Taiwan and the South China Sea, making it a key US ally in Asia [2][7] - The Philippines is caught in the middle of the US-China power struggle, with its foreign policy direction having global consequences [4][6] - China's territorial claims in the South China Sea, represented by the "10-dash line," are disputed by the Philippines and an UN court ruling [21] - The US has access to nine locations in the Philippines to rotate troops, some near Taiwan and the South China Sea, indicating a long-term presence [18] Political Dynamics & Internal Conflicts - The political feud between President Marcos Jr and Vice President Sara Duterte is impacting the country's foreign policy [1][5][8] - Sara Duterte has expressed a desire for closer ties with China and a more neutral stance between the US and China [3][6][18][19] - Tensions escalated when Marcos' government acted on an ICC arrest warrant against Duterte's father, former President Rodrigo Duterte [15] - The alliance between the Marcos and Duterte families, known as the "Uniteam," has fractured due to disagreements over policy and positions [11][12] Economic & Trade Implications - The Philippines' post-pandemic economy has grown steadily, outpacing many regional peers [7] - The Philippines is a target of US trade anger and tariff wars, with exports to the US facing a 19% tariff [24] - The Trump administration's economic pressure on allies could push the Philippines towards China [28] - Marcos Sr and his wife are accused of stealing $10 billion USD from the state during his term [9]

We'd be remiss if we didn't talk a little bit about Pelaton. Speaking of narratives, if we were sitting here in front of our respective Bloomberg terminals, we'd look and we'd be like, "Whoa, that was a big high." And now it is not where it was. It has been quite a journey to to say the least.You're still there. Like you have stuck through it. Why.Oh gosh. I have always believed. I still believe.I think that I I I have the unique privilege of seeing, and I'm not exaggerating, millions of comments over the y ...

Culture & Fandom - The company emphasizes the importance of creating a strong internal culture and energy, drawing parallels from the world of baseball [1] - Storytelling and ritual are identified as key components in building this culture and fostering fandom [1] - Fandom is seen as a valuable asset, with user-generated content on social media providing insights into fan behavior and preferences [3] Product & Marketing - The company leverages fan-driven trends and rituals, such as the association of the color yellow with specific activities, to inform product development and marketing strategies [3] - The company aims to integrate details observed from fan behavior, whether in venues or on social media, into the larger brand story and product offerings [3] - The company seeks individuals who can identify and capitalize on these fan-driven details [3]

You worked at one of the most respected law firms. So, explain to me like when is the moment that you look in the mirror and say, "I'm at a great law firm. I have a great career, great trajectory, young lawyer, doing well. I want to go do something else." Most people would think that's crazy. Well, especially like I don't know.I come from a refugee immigrant family. My dad, you know, grew up in the Bronx and was born in Puerto Rico. My mom is a Cuban refugee.And to think that I would leave something that wa ...

AI Development & Strategy - Apple's initial lead in AI with the acquisition of Siri in 2011 was quickly surpassed by competitors like Amazon and Google [5][6] - Apple's efforts to rebuild Siri, including hiring Google's AI executive John Giannandrea, have faced setbacks, with projects being scrapped [7] - Apple Intelligence, revealed in June 2024, was considered a disappointment, particularly regarding Siri's AI features, impacting the iPhone 16 launch [10][12][13] - Apple is exploring partnerships with companies like Google, OpenAI, and Anthropic to integrate their foundation models into Siri [17] - Apple's caution regarding data privacy limits its ability to train AI models effectively, despite having access to vast amounts of user data [21][23] Financial Implications & Investment - AI shortcomings have negatively impacted Apple's share price performance compared to other tech giants [14] - Apple's investment in AI is significantly less than competitors like Amazon, Google, Microsoft, and Meta, who are investing billions of dollars [20] - Apple's reluctance to invest large sums without guaranteed returns hinders its progress in the expensive and rapidly evolving field of generative AI [19] - Competitors are aggressively poaching Apple's AI talent with lucrative pay packages, sometimes exceeding $200 million over several years [25] Future Outlook & Competitive Landscape - Apple is developing new products and features, including a rebuilt Siri, to catch up in the AI race, recognizing AI's potential impact [27] - Apple risks being overtaken by competitors if it doesn't make significant acquisitions or partnerships to enhance its AI capabilities [28]

Drug Approval & Efficacy - Half (50%) of approved cancer drugs lack proof of extending survival for approved uses [1] - The pharmaceutical industry's primary motive is generating profits for shareholders [1] - Financial pressures can lead to rushed clinical trials and approvals based on uncertain evidence [2] Treatment & Dosage - Lower dosages can result in less revenue for pharmaceutical companies [2] - A second line of treatment may not always be beneficial for patients [2] Patient Needs & Conflicts - Clinicians and researchers should focus on patient needs, which can sometimes conflict with other factors [3]

Environmental Concerns & Regulatory Awareness - The Permian Basin's oil and gas operations are significantly driving earthquakes, primarily due to produced water reinjection, not hydrofracking [5] - Shallow wastewater disposal, intended to alleviate earthquake risks, is causing leaks and surface flows, indicating a shift in environmental hazards [6][7][14] - The Railroad Commission of Texas was aware of the hazards associated with increased reservoir pressure, including well damage, corrosion, and harm to water sources, yet proceeded with shallow disposal [15] Water Management Challenges - For every barrel of oil produced in the Permian Basin, three to five barrels of toxic wastewater are generated, containing high salinity, oil residue, heavy metals, and radioactive materials [3] - The volume of produced water is escalating, reaching 25 to 30 million barrels per day, exacerbating the water disposal problem [19] - Reusing treated produced water is being explored as a solution to supplement fresh water sources for industrial and agricultural applications, potentially addressing about half of the produced water volume [16][17][18] Permian Basin Significance - The Permian Basin is a major shale oil production area, comparable in size to the combined oil production of Iraq and Kuwait if it were an OPEC member [2] - Over-injection of water from horizontal wells is pushing crude oil through old well bores, leading to leaks and surface contamination [9]

[Music] Diplomacy is really about two things. It's about state relations and then it's about personal relations and connections. And then I think it's my job to try to connect with people and and I and I hope I I hope I succeed sometimes.You know, I when I was with President Xi, I felt we had a very good and respectful conversation. When I was playing golf with President Trump, we had a really good time. What was President Trump like on the golf course.You played for Yeah. Very talkative. You know, golf is ...