一、临床试验申请的主要内容 药品名称：WST04 制剂（胶囊） 证券代码：601607 证券简称：上海医药 编号：临2023-078 上海医药集团股份有限公司 关于 WST04 制剂临床试验申请获得受理的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 近日，上海医药集团股份有限公司（以下简称"上海医药"或"公司"）全 资子公司上海上药信谊药厂有限公司（以下简称"上药信谊"）收到国家药品监 督管理局下发的关于 WST04 制剂（胶囊）（以下简称"WST04 制剂"或"该项目"） 的临床试验申请《受理通知书》。现将相关情况公告如下： 剂型：胶囊 申请事项： 境内生产药品注册临床试验 受理号：CXSL2300644 结论：根据《中华人民共和国行政许可法》第三十二条的规定，经审查，决 定予以受理。 二、该项目研发及注册情况 WST04制剂是一种口服微生态活菌制剂，拟用于治疗晚期恶性实体瘤。 临床前研究显示WST04制剂可显著增强免疫检查点抑制剂的抗肿瘤作用。 该项目由上药信谊自主研发，并拥有完全知识产权。截至目前，全球尚 ...

上海医药集团股份有限公司 关于 2019 年 A 股股票期权激励计划 首次授予股票期权第二个行权期及预留股票期权第一个行 权期限制行权期间的提示性公告 证券代码：601607 证券简称：上海医药 编号：临 2023-077 二、本次限制行权期为2023年9月28日至2023年10月27日，在此期间全部激 励对象将限制行权。 三、公司将按照有关规定及时向中证登上海分公司申请办理限制行权相关事 宜。 特此公告。 上海医药集团股份有限公司 1 董事会 二零二三年九月二十一日 2 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 根据《上市公司股权激励管理办法》、《上海证券交易所上市公司自律监管 指南第2号—业务办理》、《上海医药集团股份有限公司2019年股票期权激励计 划（草案）》及中国证券登记结算有限责任公司上海分公司（以下简称"中证登 上海分公司"）关于股票期权自主行权的相关规定，并结合上海医药集团股份有 限公司（以下简称"公司"）2023年第三季度报告披露计划，现对公司2019年股 票期权激励计划首次授予股票期权第二个行权 ...

Financial Performance - The company reported a revenue of RMB 20 billion for the first half of 2023, representing a year-on-year increase of 15%[14]. - The net profit attributable to shareholders was RMB 2.5 billion, up 10% compared to the same period last year[14]. - The company's operating revenue for the first half of the year reached ¥132.59 billion, an increase of 18.70% compared to ¥111.71 billion in the same period last year[21]. - Net profit attributable to shareholders decreased by 29.38% to ¥2.61 billion from ¥3.70 billion year-on-year[21]. - Basic earnings per share fell by 37.17% to ¥0.71 from ¥1.13 in the previous year[23]. - The net cash flow from operating activities improved significantly to ¥1.64 billion, compared to a negative cash flow of ¥556.18 million in the same period last year[21]. - The total comprehensive income attributable to the parent company's shareholders for the six months ended June 30, 2023, was RMB 2.48 billion, down from RMB 3.53 billion in the same period of 2022, reflecting a decrease of approximately 29.8%[190]. - The net profit for the six months ended June 30, 2023, was RMB 3.42 billion, compared to RMB 4.56 billion for the same period in 2022, indicating a decline of 25.1%[197]. Market Expansion and Product Development - User data showed an increase in active users by 25% to 5 million during the reporting period[14]. - The company plans to launch three new products in the second half of 2023, targeting a market expansion of 30% in the next fiscal year[14]. - Market expansion efforts include entering two new international markets by the end of 2023[14]. - The company plans to continue expanding its market presence and investing in new product development to drive future growth[188]. - The company reported a 24% year-on-year sales increase in its innovative drug segment, successfully introducing 14 new imported products during the reporting period[51]. Research and Development - Research and development expenses increased by 20% to RMB 1 billion, focusing on innovative drug development[14]. - Research and development investment reached RMB 1.218 billion, a year-on-year increase of 25.91%, with R&D expenses at RMB 1.026 billion, up 26.76%[42]. - The company has a new drug pipeline of 64 projects, with 3 projects having submitted pre-NDA or listing applications[42]. - The NDA application for I001 tablets, a new generation oral non-peptide renin inhibitor for hypertension, was accepted in June 2023, with significant trial results achieved[42]. - The NDA application for X842, a new generation potassium competitive acid blocker for gastroesophageal reflux disease, was accepted in February 2023, with a market potential of RMB 13 billion based on 2022 sales data[43]. Financial Stability and Structure - Total assets increased by 7.66% to ¥213.32 billion from ¥198.13 billion at the end of the previous year[21]. - The company maintains a strong financial structure with good control over its asset-liability ratio, leveraging A+H share listings and various investment platforms for capital operation[37]. - The asset-liability ratio increased by 2.36 percentage points to 62.99% at the end of the reporting period[70]. - The company reported a total of RMB 964,650.00 million in credit business with Shanghai Shanshi Group Financial Co., Ltd., with actual occurrences amounting to RMB 217,273.12 million[146]. Corporate Governance and Compliance - The board of directors confirmed the accuracy and completeness of the financial report, with no major omissions[6]. - The company strictly adhered to all applicable provisions of the Corporate Governance Code as per the Hong Kong Listing Rules during the reporting period[116]. - The Audit Committee reviewed and approved the company's 2023 semi-annual report and the accounting treatment methods adopted[120]. - The company confirmed compliance with the Standard Code for securities transactions by directors during the reporting period[117]. Employee Engagement and Compensation - As of June 30, 2023, Shanghai Pharmaceuticals employed 47,811 people, including 1,540 R&D personnel[76]. - The company has implemented a differentiated compensation system based on position, ability, performance, and market, enhancing employee motivation and aligning with corporate performance[76]. - The stock option incentive plan aims to align the interests of senior management and core employees with the long-term development of the company[81]. Environmental and Social Responsibility - The company is actively responding to the "Healthy China 2030" strategy, focusing on the development of innovative drugs and improving supply chain solutions[27]. - The company is focused on becoming a resource-saving and environmentally friendly group, continuously improving its environmental and energy management systems[122]. - The company plans to implement 69 energy-saving projects, expecting to save approximately RMB 8.3 million, 9.911 million kWh of electricity, 320.1 tons of steam, 446,500 cubic meters of natural gas, and 31,700 tons of water by year-end[122]. Related Party Transactions - The company engaged in related party transactions amounting to RMB 22,884.92 million for procurement and RMB 30,715.79 million for sales with related parties, both representing 100% of similar transactions[135]. - The company reported a total of RMB 3,093.25 million in related party transactions for product procurement and service acceptance, also at 100% of similar market prices[135]. Future Outlook - In the second half of 2023, the company aims to enhance its scale effect and comprehensive strength by actively serving national strategies and promoting major product strategies, with a focus on investment and acquisitions[102]. - The company will continue to increase R&D investment and optimize resource allocation to enhance innovation competitiveness[69].

证券代码：601607 证券简称：上海医药 编号：临2023-075 上海医药集团股份有限公司 关于 I035 临床试验申请获得受理的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者重 大遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 近日，上海医药集团股份有限公司（以下简称"上海医药"或"公司"）开发的"I035" （以下简称"I035"或"该项目"）临床试验申请获得国家药品监督管理局（以下简称 "国家药监局"）受理，现将相关情况公告如下： 一、该药物基本信息 项目编号：I035 剂型：颗粒剂 申请事项：境内生产药品注册临床试验 申报受理号：CXHL2300964、CXHL2300965、CXHL2300966 结论：根据《中华人民共和国行政许可法》第三十二条的规定，经审查，决定予以 受理。 二、该药物研发及注册情况 I035 是一款免疫调节剂，能抑制肠道的炎症反应和增强肠道的免疫调节。临床前研 究显示 I035 能改善肠炎动物模型的症状和肠道的炎症反应。 该项目由上海医药集团股份有限公司自主研发，上海医药集团股份有限公司拥有完 全知识产权。截至本公告披露日，该项目 ...

上海医药集团股份有限公司 关于控股股东增持公司 H 股股份的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 证券代码：601607 证券简称：上海医药 编号：临2023-076 一、本次增持的基本情况 2023 年 9 月 11 日，上海医药集团股份有限公司（以下简称"上海医药"或 "公司"）收到上海实业（集团）有限公司（以下简称"上实集团"）通知，上 实集团通过下属全资子公司上实国际投资有限公司（以下简称"上实国际"）增 持了公司 H 股 100,000 股，约占公司总股本（截至 2023 年 9 月 10 日，公司总股 本为 3,703,301,054 股）的 0.003%。 本次增持前，上实集团持有公司股票 1,344,356,237 股（其中：A 股 1,125,817,837 股，H 股 218,538,400 股），约占公司总股本的 36.302%；本次增 持后，上实集团持有公司股票 1,344,456,237 股（其中：A 股 1,125,817,837 股， H 股 218,638,400 股），约 ...

证券代码：601607 证券简称：上海医药 编号：临 2023-074 一、该药品的基本情况 药品名称：注射用阿奇霉素 商品名称：锋达齐 上海医药集团股份有限公司 关于注射用阿奇霉素通过仿制药一致性评价的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者重 大遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 近日，上海医药集团股份有限公司（以下简称"上海医药"或"公司"）控股子公司上 海上药新亚药业有限公司（以下简称"上药新亚"）收到国家药品监督管理局（以下简称 "国家药监局"）颁发的关于注射用阿奇霉素（以下简称"该药品"）的《药品补充申请批 准通知书》（通知书编号：2023B04101），该药品通过仿制药一致性评价。 剂型：注射剂 规格：0.5g 注册分类：化学药品 原批准文号：国药准字H20056283 根据国家相关政策，通过一致性评价的药品品种在医保支付及医疗机构采购等领域将 获得更大的支持力度。因此上药新亚的注射用阿奇霉素通过仿制药一致性评价，有利于扩 大该药品的市场份额，提升市场竞争力，同时为公司后续产品开展仿制药一致性评价工作 积累了宝贵的经验。 因受国家政策 ...

证券代码：601607 证券简称：上海医药 编号：临2023-073 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 董事会 二零二三年九月七日 上海医药集团股份有限公司（以下简称"本公司"）于 2022 年 9 月 5 日收到 上海实业（集团）有限公司（以下简称"上实集团"）通知，上实集团计划在此 后的 12 个月内通过下属全资子公司上实国际投资有限公司（以下简称"上实国 际"）于二级市场增持本公司 H 股股份，增持比例不超过本公司已发行总股本的 2%（详见公司公告临 2022-072 号）。 截至 2023 年 9 月 4 日香港联合交易所有限公司收市，上实集团增持本公司 H 股股份计划已经实施完毕。本次增持期间内，上实集团通过上实国际增持了本 公司 H 股股份共计 43,647,200 股，约占本公司已发行 H 股股份总数（即 919,072,704 股）的 4.749%，占已发行股份总数（截至 2023 年 9 月 4 日，公司 总股本为 3,703,301,054 股）的 1.179%。本次增持计划完成后，上实 ...

敬请广大投资者理性投资，注意投资风险。 特此公告。 上海医药集团股份有限公司 董事会 证券代码：601607 证券简称：上海医药 编号：临 2023-072 上海医药集团股份有限公司 关于原管理人员接受纪律审查和监察调查的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 根据上海市监察委员会官网于近日公示消息，上海医药集团股份有限公司 （以下简称"公司"）原副总裁潘德青先生，下属子公司上海上药第一生化药业 有限公司（以下简称"上药第一生化"）原总经理陈彬华先生，下属子公司上海 上柯医药有限公司原总经理李平先生涉嫌严重违纪违法，正在接受上海市闵行区 纪委监委纪律审查和监察调查；上药第一生化原副总经理黄臻辉先生涉嫌严重违 法，正在接受上海市闵行区监察委员会监察调查。公司目前尚不知悉前述人员被 调查的具体原因。 截至本公告披露日，上述人员均已不在公司任职。公司拥有完善的治理结构 及内部控制机制，按照《公司法》、《上海证券交易所股票上市规则》、《上市公司 治理准则》及《公司章程》等法律法规和相关制度规范运作，日常生产经营活动 ...

上海医药集团股份有限公司 证券代码：601607 证券简称：上海医药 公告编号：临2023-071 上海医药集团股份有限公司 关于高级管理人员辞任的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 近日，上海医药集团股份有限公司（以下简称"本公司"）董事会接到潘德青 先生的书面辞呈。因个人原因，潘德青先生辞去本公司副总裁及在本公司附属子 公司担任的全部职务，辞呈自送达本公司董事会之日起生效。该事项对本公司日 常经营无重大影响。 特此公告。 董事会 二零二三年九月二日 1 ...

Financial Performance - The company's operating revenue for the first half of 2023 reached ¥132.59 billion, an increase of 18.70% compared to ¥111.71 billion in the same period last year[19]. - The net profit attributable to shareholders of the listed company was ¥2.61 billion, a decrease of 29.38% from ¥3.70 billion in the previous year[19]. - The net profit attributable to shareholders after deducting non-recurring gains and losses was ¥2.20 billion, down 17.96% from ¥2.68 billion in the same period last year[19]. - The net cash flow from operating activities was ¥1.64 billion, a significant improvement from a negative cash flow of ¥556.18 million in the previous year[19]. - Total assets at the end of the reporting period amounted to ¥213.32 billion, reflecting a growth of 7.66% from ¥198.13 billion at the end of the previous year[19]. - The net assets attributable to shareholders of the listed company increased to ¥67.36 billion, a slight rise of 0.44% from ¥67.06 billion at the end of the previous year[19]. - Basic earnings per share decreased by 37.17% to CNY 0.71 compared to CNY 1.13 in the same period last year[21]. - Diluted earnings per share also decreased by 37.17% to CNY 0.71 from CNY 1.13 year-on-year[21]. - The weighted average return on equity fell by 2.54 percentage points to 3.82% from 6.36% in the previous year[21]. Revenue Segmentation - The pharmaceutical industrial segment generated revenue of RMB 14.699 billion, up 12.64% year-on-year, while the pharmaceutical commercial segment reported revenue of RMB 117.893 billion, a growth of 19.50%[38]. - The company's traditional Chinese medicine segment achieved industrial revenue of RMB 5.120 billion, a year-on-year increase of 21.64%[45]. - The sales of innovative drugs increased by about 24%, with 14 new imported products introduced during the reporting period[53]. Research and Development - Research and development investment reached RMB 1.218 billion, a year-on-year increase of 25.91%, with R&D expenses at RMB 1.026 billion, up 26.76%[41]. - The company has 64 new drug candidates in its pipeline, with 3 already submitted for pre-NDA or market application[41]. - The NDA application for I001, a new oral non-peptide renin inhibitor for hypertension, was accepted in June 2023, with significant market potential as the hypertension drug market in China was valued at RMB 26.75 billion in 2022[41]. - The company emphasizes R&D innovation, maintaining a leading position in R&D investment intensity within the industry[33]. Strategic Partnerships and Market Position - The company has established strategic partnerships with major domestic and international pharmaceutical manufacturers to enhance supply chain solutions[28]. - The company ranked 41st in the 2023 global pharmaceutical companies TOP50 and 3rd in the 2022 China pharmaceutical industry TOP100[27]. - The company is the second-largest pharmaceutical commercial enterprise in China, with a distribution network covering 25 provinces and municipalities[28]. Environmental Compliance and Sustainability - The company is committed to maintaining compliance with environmental regulations and improving its sustainability practices[130]. - The company has implemented online monitoring devices at wastewater discharge points to ensure compliance with environmental standards[135]. - The company has invested in multiple sets of air treatment facilities to manage emissions effectively[135]. - The company achieved 100% compliance in environmental monitoring from January to June 2023, with all monitored parameters meeting standards[149]. - The company plans to complete hardware facility rectifications by the end of 2023 to meet environmental requirements[147]. Corporate Governance and Compliance - The company strictly adhered to all applicable provisions of the Corporate Governance Code as per the Hong Kong Listing Rules during the reporting period[121]. - The board confirmed compliance with the Standard Code for Securities Transactions by Directors, ensuring all directors and supervisors fully adhered to the code during the reporting period[123]. - The audit committee reviewed and approved the accounting treatment methods adopted in the 2023 interim report[126]. Stock Options and Incentive Plans - The company has granted a total of 25,600,000 stock options, which were later adjusted to 23,258,120 due to changes in the number of participants[83]. - The stock options granted under the incentive plan amount to 25,025,520 shares, representing 1% of the company's total issued shares as of the report date[91]. - The exercise price for the stock options is set at RMB 18.41 per A-share, subject to adjustments for corporate actions[96]. - The incentive plan aims to align the interests of management with the long-term development of the company and prevent talent loss[85]. Legal and Regulatory Matters - The company has no significant pending litigation or arbitration to disclose during the reporting period[78]. - There are no significant lawsuits or arbitration matters affecting the company during the reporting period[169]. - The company has committed to not engaging in non-operational fund occupation by controlling shareholders and related parties[167]. Financial Transactions and Related Party Transactions - The total amount of related party transactions for the company was 22,884.92 million, representing 100% of the total transactions[171]. - The company reported a total of 3,093.25 million in related party purchases, which accounted for 100% of the related transactions[171]. - The company had a loan amount of 600,000.00 million with an interest rate range of 2.30%-5.00%[178].