ROCKVILLE, Md. and SUZHOU, China, Oct. 29, 2025 (GLOBE NEWSWIRE) -- Ascentage Pharma Group International (NASDAQ: AAPG; HKEX: 6855) (“Ascentage Pharma” or the “Company”), a global, commercial stage, integrated biopharmaceutical company engaged in the discovery, development and commercialization of novel, differentiated therapies to address unmet medical needs in cancer, announced today that the Company's management is scheduled to participate in the following investor conferences in November 2025. Goldman S ...

ROCKVILLE, Md. and SUZHOU, China, Oct. 29, 2025 (GLOBE NEWSWIRE) -- Ascentage Pharma Group International (NASDAQ: AAPG; HKEX: 6855) (“Ascentage Pharma” or the “Company”), a global, commercial stage, integrated biopharmaceutical company engaged in the discovery, development and commercialization of novel, differentiated therapies to address unmet medical needs in cancer, announced today that the Company's management is scheduled to participate in the following investor conferences in November 2025. Goldman S ...

Summary of the Conference Call for Ascentage Pharma Industry and Company Overview - The conference call focuses on Ascentage Pharma, a biopharmaceutical company specializing in innovative cancer therapies, particularly in the field of apoptosis and targeted therapies [2][3]. Key Points and Arguments 1. **Orebatein Expansion**: Orebatein, a third-generation TKI, expanded its indications in October 2023 to cover more CML patients, with expectations to be included in the national health insurance by the end of 2024, significantly enhancing market potential. The domestic sales reached 217 million yuan, with a forecasted doubling for the year [2][4]. 2. **BCL-2 Inhibitor Launch**: Ascentage Pharma launched its first domestic BCL-2 inhibitor, targeting relapsed CLL/SLL, which has a superior administration method compared to venetoclax, faster cellular uptake, and higher safety. Multiple phase III registration trials are ongoing, indicating a broad market outlook [2][4]. 3. **Collaboration with Takeda**: The company entered a licensing agreement with Takeda for the drug Nilotinib, with a total transaction value of 1.3 billion USD, including an upfront payment of 100 million USD. The remaining amount consists of milestone payments and sales sharing, with three phase III registration trials currently in progress [2][5]. 4. **Sales and R&D Expenses**: In the first half of 2024, sales expenses were 138 million yuan, with an annual estimate of 250 to 300 million yuan. R&D expenses reached 529 million yuan, with expectations to exceed 1 billion yuan for the year, indicating a continued increase in R&D investment [2][5]. 5. **Clinical Trials**: Orebatein is undergoing three phase III registration trials, while the BCL-2 inhibitor is also in multiple phase III trials covering AML, CLL/SLL, MDS, and multiple myeloma [2][6]. 6. **CML Market Size**: The global TKI market for CML is approximately 6 billion USD, with the domestic market around 4 billion yuan. The rapid growth of third-generation TKIs is noted, with Nilotinib being the only domestic third-generation TKI, providing a competitive edge [2][7][8]. Additional Important Information 1. **Market Competition**: The global CML TKI market is characterized by the expiration of patents for first and second-generation TKIs, with significant market players like Novartis and Takeda. Orebatein is positioned to complete its overseas phase III trials and apply for market approval by 2026 [7][9]. 2. **Advantages of BCL-2 Inhibitor**: Compared to venetoclax, Ascentage's BCL-2 inhibitor offers advantages in administration, faster cellular uptake, and lower side effects due to a shorter half-life. Ongoing trials include combinations with other therapies for various indications [2][11]. 3. **Future Directions**: Ascentage Pharma aims to continue its focus on apoptosis pathways and advance new L-type inhibitors for solid tumors, while also pursuing international expansion and product innovation to meet market expectations [3][12].

Core Viewpoint - Ascentage Pharma Group International is actively participating in several investor conferences in October 2025, highlighting its ongoing commitment to engage with investors and stakeholders in the biopharmaceutical sector [1][7]. Company Overview - Ascentage Pharma is a global, commercial stage, integrated biopharmaceutical company focused on discovering, developing, and commercializing novel therapies for unmet medical needs in cancer [2][5]. - The company has developed a robust pipeline of innovative drug products, including inhibitors targeting key apoptotic pathway proteins and next-generation kinase inhibitors [2]. Product Portfolio - The first approved product, Olverembatinib, is a third-generation BCR-ABL1 inhibitor for chronic myelogenous leukemia (CML) patients with specific mutations and is included in the China National Reimbursement Drug List [3]. - The second approved product, Lisaftoclax, is a Bcl-2 inhibitor for various hematologic malignancies, with multiple global registrational Phase III trials currently underway [4]. Research and Development - Ascentage Pharma has established a strong R&D capability and has built a portfolio of global intellectual property rights [5]. - The company has formed partnerships with leading biotechnology and pharmaceutical companies, including Takeda, AstraZeneca, Merck, and Pfizer, as well as collaborations with prominent research institutions [5].

Summary of Ascentage Pharma Conference Call Company Overview - **Company**: Ascentage Pharma - **Core Products**: Olverembatinib (APG-115), Fayankirin, APG-2,575 - **Industry**: Pharmaceutical/Biotechnology Key Points and Arguments Product Performance 1. **Olverembatinib (APG-115)**: - Sales doubled in the first half of 2024 after being included in the medical insurance coverage, with expectations to maintain the same growth rate in the second half [2][4][7] - Targeting chronic myeloid leukemia (CML) with significant market potential for future growth [2][4] 2. **Fayankirin**: - Currently undergoing POS D1 trials in China and Phase III registration trials in the U.S. [2][4] - Key data on 3-6 month MMR and 3 month CMR rates expected soon [2][4] 3. **APG-2,575**: - Launched in July 2024, it is the second BCL-2 inhibitor globally and the first for CLL in China [2][5] - Expected peak sales could exceed $4 billion, providing substantial growth potential [3][16] Financial Position 4. **Funding and Cash Reserves**: - Completed two rounds of financing through NASDAQ IPO and Hong Kong placement, currently holding approximately 3 billion RMB, sufficient to meet funding needs until 2027 [2][5] 5. **Collaboration with Takeda**: - A $100 million option payment and $75 million equity investment from Takeda, with potential future payments and royalties of 12%-19% [6] Market Dynamics 6. **Sales Performance in Hematology**: - Sales in the hematology sector have exceeded expectations due to the chronic disease management characteristics of the drugs, leading to sustained use by existing patients and an increase in new patients [9] - The company leverages the DOT (Duration of Therapy) effect to enhance sales [9] Clinical Development and Future Catalysts 7. **Clinical Trials and Pipeline**: - APG-2,575's daily dose escalation improves patient compliance and safety, with a faster onset of action compared to competitors [3][12] - The company is also advancing FAK inhibitor 2,449 into Phase III trials, with potential for commercial value through combination therapies [3][17] 8. **Comparative Advantage**: - APG-2,575 shows better safety and efficacy profiles compared to existing treatments like Venetoclax, with a lower rate of dose reduction and treatment interruption [13][16] Future Plans 9. **Upcoming Milestones**: - Plans to initiate the next U.S. registration clinical study and complete multiple Phase III clinical enrollments for APG-115 and APG-2,575 by 2026 [19] 10. **Expansion into New Areas**: - The company is exploring additional therapeutic areas, including apoptosis pathway inhibitors and anemia treatments, indicating a broadening of its research pipeline [17][18] Additional Important Insights - **Market Trends**: - BCL-2 inhibitors are gaining traction in hematological malignancies, with a focus on selective targeting to improve safety and efficacy [14][15] - **Strategic Positioning**: - The company’s strong cash position and ongoing clinical trials position it well for future growth and market expansion [5][19]

Company Overview - Ascentage is undergoing significant developments and has recently provided updates on its progress and milestones [1][2] Recent Updates - The company had its first half update a couple of weeks ago, highlighting key progress and future milestones [1][2]

Core Viewpoint - Ascentage Pharma Group International - Unsponsored ADR has received a Zacks Rank 2 (Buy) upgrade, indicating a positive outlook on its earnings estimates, which is a significant factor influencing stock prices [1][4]. Earnings Estimates and Stock Ratings - The Zacks rating system is primarily based on a company's changing earnings picture, tracking the Zacks Consensus Estimate for EPS from sell-side analysts [2]. - The Zacks rating upgrade reflects an improvement in the earnings outlook for Ascentage Pharma, which could lead to increased buying pressure and a rise in stock price [4][6]. Impact of Earnings Estimate Revisions - Changes in a company's future earnings potential, as indicated by earnings estimate revisions, are strongly correlated with near-term stock price movements, particularly due to institutional investors' reliance on these estimates for valuation [5]. - Rising earnings estimates and the subsequent rating upgrade suggest an improvement in Ascentage Pharma's underlying business, which should be recognized by investors through a higher stock price [6]. Zacks Rank System - The Zacks Rank stock-rating system classifies stocks into five groups based on earnings estimates, with a strong historical performance, particularly for Zacks Rank 1 stocks, which have averaged a +25% annual return since 1988 [8]. - The upgrade of Ascentage Pharma to a Zacks Rank 2 places it in the top 20% of Zacks-covered stocks, indicating a strong potential for market-beating returns in the near term [11]. Earnings Estimate Revisions for Ascentage Pharma - For the fiscal year ending December 2025, Ascentage Pharma is expected to earn -$1.13 per share, with no year-over-year change; however, the Zacks Consensus Estimate has increased by 20.4% over the past three months [9].

Core Viewpoint - Ascentage Pharma Group International's stock has recently experienced a decline of 11.3% over the past week, but the formation of a hammer chart pattern suggests a potential trend reversal due to increased buying interest and bullish sentiment among analysts [1][2]. Technical Analysis - The hammer chart pattern indicates a potential bottoming out, characterized by a small candle body and a long lower wick, suggesting that selling pressure may be exhausting [4][5]. - This pattern typically forms during a downtrend when the stock opens lower, makes a new low, but then closes near or above the opening price, indicating a shift in control from bears to bulls [4][5]. Fundamental Analysis - There has been a positive trend in earnings estimate revisions for Ascentage Pharma, with a 20.4% increase in the consensus EPS estimate for the current year over the last 30 days, indicating that analysts expect better earnings than previously predicted [7][8]. - The company currently holds a Zacks Rank of 2 (Buy), placing it in the top 20% of over 4,000 ranked stocks, which historically outperforms the market [9][10].

Group 1 - U.S. stocks experienced mixed performance, with the Dow Jones index declining over 200 points on Monday [1] - Keurig Dr Pepper Inc. shares fell sharply by 7.8% to $32.38 following the announcement of its acquisition of JDE Peet's [1] - Valneva SE shares dropped 21% to $9.19 after the FDA suspended the license for IXCHIQ [3] Group 2 - DeFi Development Corp. saw its shares dip 18% to $16.51 after announcing a $125 million offering of 4.2 million shares at $12.50 per share [3] - Venu Holding Corporation's shares fell 13.3% to $15.56 after announcing an offering of 1.7 million shares [3] - Axogen, Inc. shares declined 10.2% to $14.60 due to an FDA Major Amendment designation delaying the Avance Nerve Graft decision to December 5, 2025 [3]

Core Viewpoint - Ascentage Pharma Group International is actively participating in investor conferences in September 2025 to discuss its advancements in biopharmaceuticals, particularly in cancer therapies [1][8]. Company Overview - Ascentage Pharma is a global, commercial stage, integrated biopharmaceutical company focused on discovering, developing, and commercializing novel therapies for unmet medical needs in cancer [3][4]. - The company has developed a rich pipeline of innovative drug products, including inhibitors targeting key proteins in the apoptotic pathway and next-generation kinase inhibitors [3][4]. Product Pipeline - The first approved product, Olverembatinib, is a third-generation BCR-ABL1 inhibitor for treating chronic myeloid leukemia (CML) with T315I mutations and is included in China's National Reimbursement Drug List [4]. - Olverembatinib is currently undergoing registrational Phase III trials, including POLARIS-2 for CML and POLARIS-1 and POLARIS-3 for other specific patient groups [4]. - The second approved product, Lisaftoclax, is a Bcl-2 inhibitor for various hematologic malignancies and has been approved for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) patients who have received prior systemic therapy [5]. - Lisaftoclax is involved in four global registrational Phase III trials, including studies in combination with BTK inhibitors and for newly diagnosed patients [5]. Research and Development - Ascentage Pharma has established a robust R&D capability and holds a portfolio of global intellectual property rights [6]. - The company has formed partnerships with leading biotechnology and pharmaceutical companies, including Takeda, AstraZeneca, Merck, and Pfizer, as well as collaborations with prominent research institutions [6].