Apellis Pharmaceuticals Inc. (NASDAQ:APLS) is one of the best high short interest stocks with biggest upside potential. On January 21, Bank of America analyst Tazeen Ahmad upgraded Apellis to Buy from Neutral with an unchanged price target of $28. BofA maintains that the market is currently undervaluing Empaveli’s commercial prospects in treating rare kidney diseases, citing a robust launch trajectory that has already secured 267 new patient start forms since its late July approval. This initial 5% penetra ...

Apellis Pharmaceuticals, Inc. (APLS) shares ended the last trading session 5.8% higher at $23.07. The jump came on an impressive volume with a higher-than-average number of shares changing hands in the session. This compares to the stock's 13.6% loss over the past four weeks.The sudden price rise can be attributed to growing investor optimism related to the company’s marketed product, Empaveli (pegcetacoplan), which is approved for treating paroxysmal nocturnal hemoglobinuria in the United States. The drug ...

Top Wall Street analysts changed their outlook on these top names. For a complete view of all analyst rating changes, including upgrades, downgrades and initiations, please see our analyst ratings page.Considering buying OKLO stock? Here’s what analysts think: Photo via Shutterstock ...

NEW YORK, Jan. 27, 2026 /PRNewswire/ -- S&P Dow Jones Indices will make the following changes to the S&P MidCap 400, S&P SmallCap 600: S&P SmallCap 600 constituent TTM Technologies Inc. (NASD: TTMI) will replace Civitas Resources Inc. (NYSE: CIVI) in the S&P MidCap 400, and Amneal Pharmaceuticals Inc. (NASD: AMRX) will replace TTM Technologies in the S&P SmallCap 600 effective prior to the opening of trading on Friday, January 30. S&P SmallCap 600 constituent SM Energy Co. (NYSE: SM) is acquiring Civitas Re ...

Apellis Pharmaceuticals Inc. (NASDAQ:APLS) is gaining traction in a rare kidney disease market, with early uptake of its newly approved treatment signaling a meaningful growth inflection that could reshape the company’s revenue outlook over the next several years.Bank of America Securities (BofA) on Wednesday upgraded Apellis Pharmaceuticals, citing the company’s underappreciated C3G opportunity.Analyst Tazeen Ahmad says the current valuation underappreciates the commercial potential of Empaveli in new rare ...

Core Insights - Apellis Pharmaceuticals (APLS) received FDA approval for EMPAVELI targeting C3 glomerulopathy and IC-MPGN, with the stock trading around $28 at the time of approval [1] Company Summary - The FDA approval of EMPAVELI marks a significant milestone for Apellis Pharmaceuticals, potentially impacting its market position and stock performance [1]

Core Insights - Apellis Pharmaceuticals' stock has decreased by 31% over the past year despite receiving FDA approval for EMPAVELI, indicating a disconnect between regulatory success and commercial performance [2][7] Product Approval and Market Potential - EMPAVELI is the first and only approved treatment for C3 glomerulopathy and IC-MPGN, targeting approximately 5,000 patients in the U.S., with exclusive approval for about two-thirds of this population [3] - The positive opinion from the European CHMP in December 2025 enhances the global expansion potential and pricing power, typically associated with gross margins exceeding 90% [3] Patient Start Forms and Growth Expectations - Management has guided for 225 cumulative patient start forms by the end of 2025, having achieved 152 by the end of September, suggesting a slowdown to 24 forms per month in Q4 [4] - CEO Cedric Francois indicated that the company is moving past the initial wave of early adopters and anticipates steady growth moving into the next year [4] Revenue Challenges and Market Dynamics - SYFOVRE, which constitutes the majority of revenue, reported flat sales of $151 million in Q3 2025, with a mere 4% growth in injections, primarily driven by free goods costing the company $15 million [5] - The share of new patients for SYFOVRE has decreased to 52%, with management noting that retina specialists are adopting a cautious approach despite SYFOVRE's 60% market share [5] External Market Issues - The cessation of new co-pay assistance applications by Good Days Foundation has led to practices halting new patient enrollments, a challenge not unique to Apellis but reflective of broader issues in the geographic atrophy market [6]

Core Insights - Apellis Pharmaceuticals (APLS) shares have dropped 22.6% in the past week following disappointing preliminary fourth-quarter U.S. net product revenues reported at the J.P. Morgan Healthcare Conference [2][6] Financial Performance - Preliminary U.S. net product revenues for Q4 2025 were reported at $190 million, which includes sales from two marketed drugs: Empaveli and Syfovre [3][6] - Syfovre generated approximately $155 million in Q4 2025, reflecting an 8% year-over-year decline, although it slightly exceeded the Zacks Consensus Estimate of $154 million [4][6] - Empaveli's sales rose 50% year-over-year to about $35 million in Q4 2025, surpassing the Zacks Consensus Estimate of $28 million [6][8] - For the full year 2025, Apellis reported preliminary U.S. net product revenues of approximately $689 million, down 3% year over year [11] Market Position and Sales Dynamics - Despite holding over 60% market share in geographic atrophy (GA), Syfovre's revenue decline disappointed investors, especially as Apellis' stock has only gained 2.9% over the past six months compared to the industry's 22.9% growth [5][6] - Apellis delivered over 89,000 commercial vials and nearly 13,000 samples of Syfovre to doctors in Q4 2025 [5] Regulatory and Pipeline Updates - Empaveli has received FDA approval for expanded use in treating C3 glomerulopathy and primary immune complex glomerulonephritis [9] - As of December 31, 2025, Apellis received 267 cumulative patient start forms for Empaveli, indicating over 5% market penetration within five months post-launch [10] - The company has initiated two pivotal phase III studies for Empaveli targeting focal segmental glomerulosclerosis (FSGS) and delayed graft function (DGF) [13] - A mid-stage study of siRNA candidate APL-3007 in combination with Syfovre is ongoing, with top-line data expected in 2027 [14] Financial Position - As of December 31, 2025, Apellis had cash, cash equivalents, and marketable securities totaling $466 million, down from $479.2 million as of September 30, 2025 [15]

Group 1 - Top Wall Street analysts have revised their outlook on several prominent companies, indicating a shift in market sentiment [1] - The article suggests that investors consider buying FIVE stock, highlighting the analysts' positive perspective on its potential [1]

Group 1 - The article does not provide any relevant content regarding company or industry insights [1]