Core Insights - 100% of patients in Cohorts 1-3 remain free of cytokine release syndrome, indicating a strong safety profile for the CD3 design used in the study [1] - The study evaluates mipletamig, a CD123 x CD3 bispecific molecule, in combination with azacitidine and venetoclax for newly diagnosed acute myeloid leukemia patients unfit for intensive chemotherapy [1] - Preliminary results were presented at the American Society of Hematology Annual Meeting, highlighting the potential of the ADAPTIR™ and ADAPTIR-FLEX™ platform technologies developed by the company [1] Company Summary - Aptevo Therapeutics Inc. is a clinical-stage biotechnology company focused on developing novel immune-oncology therapeutics [1] - The company utilizes proprietary ADAPTIR™ and ADAPTIR-FLEX™ platform technologies in its research and development efforts [1] Industry Context - The ongoing Phase 1b/2 RAINIER study is significant for the treatment of acute myeloid leukemia, particularly for patients who cannot undergo intensive chemotherapy [1] - The combination of mipletamig with standard treatments like azacitidine and venetoclax represents a potential advancement in the therapeutic options available for AML [1]

Core Points - The 2025 Annual General Meeting of Frontline plc was held on December 8, 2025, in Limassol, Cyprus, where the audited consolidated financial statements for the year ended December 31, 2024, were presented [1] - Several resolutions were passed during the meeting, including the re-election of multiple directors and the appointment of auditors [2] Summary of Resolutions - Re-election of Directors: John Fredriksen, James O'Shaughnessy, Ola Lorentzon, Cato Stonex, Ørjan Svanevik, and Dr. Maria Papakokkinou [2] - Election of Richard C. Prince as a new Director [2] - Re-appointment of PricewaterhouseCoopers as auditors and authorization for the Directors to determine their remuneration [2] - Approval of the Board of Directors' remuneration not to exceed USD 600,000 for the year ended December 31, 2025 [2] - Exclusion of shareholders' right of pre-emption for a maximum of 377,377,111 ordinary shares and debentures for a period of twelve months, effective from December 8, 2025 [2] - Advisory vote approval of the Company's Remuneration Report for the year ended December 31, 2024 [2]

Core Viewpoint - Frontline plc (NYSE:FRO) experienced a significant decline in share price and missed profit estimates for Q3 2025, despite exceeding revenue forecasts, indicating challenges in the shipping sector and fluctuating market conditions [1][3]. Financial Performance - The adjusted earnings per share for Frontline in Q3 were $0.19, which was $0.05 below expectations [3]. - The net profit for the quarter decreased by over 33% year-over-year due to lower Time Charter Equivalent (TCE) rates and variations in other income and expenses [3]. - Revenue for the quarter was reported at $432.6 million, down nearly 12% year-over-year, but exceeded forecasts by over $163 million [3]. Dividend and Future Outlook - Frontline declared a quarterly dividend of $0.19 per share on November 24, demonstrating commitment to shareholders [4]. - The company noted a significant rate increase in Q4, driven by changes in U.S. refinery operations and demand shifts in Asia, particularly regarding Russian crude [4]. - CEO Lars H. Barstad highlighted the strengthening freight markets, especially for Very Large Crude Carriers (VLCCs), and expressed optimism about the fundamentals as the company enters the winter market with high freight rates [4].

Core Viewpoint - Frontline plc (FRO) has shown strong performance in the tanker market, leading to a reaffirmation of a buy rating based on impressive Q2 results [1] Group 1: Company Performance - The company reported significant gains in Q2, which has positively influenced the investment outlook [1] - The analyst has maintained a long position in FRO shares, indicating confidence in the company's future performance [2] Group 2: Market Context - The tanker industry is experiencing favorable conditions, which are expected to continue benefiting companies like Frontline [1]

Core Insights - Investors will have a break next week due to the market closure on November 27 for Thanksgiving, allowing time for assessment and reflection after a challenging week for Wall Street [2] - Despite the end of the U.S. government shutdown, some key economic reports are still being canceled due to insufficient survey data, impacting market expectations [3] Earnings Reports - Several companies are scheduled to report earnings next week, including Alibaba Group (BABA), Dell (DELL), Deere & Company (DE), Analog Devices (ADI), Best Buy (BBY), HP (HPQ), and DICK'S Sporting Goods (DKS) [4] - Specific earnings highlights include: - Monday: Agilent Technologies (A), Zoom Communications (ZM), Symbotic (SYM) [5] - Tuesday: Alibaba, Analog Devices (ADI), Dell Technologies, Best Buy (BBY), Autodesk (ADSK), Workday (WDAY), Zscaler (ZS), HP (HPQ), DICK'S Sporting Goods, J.M. Smucker (SJM), and NIO (NIO) [5] - Wednesday: Deere, Li Auto (LI) [5] - Thursday: Intuitive Machines (LUNR) [6] - Friday: Frontline Plc (FRO), Buckle, Inc. (BKE) [6]

Financial Data and Key Metrics Changes - In the third quarter of 2025, the company reported a profit of $40.3 million, or $0.18 per share, with an adjusted profit of $42.5 million, or $0.19 per share. This adjusted profit decreased by $37.8 million compared to the previous quarter, primarily due to a decline in time charter earnings from $283 million to $248 million [4][5] - Ship operating expenses increased by $3.1 million from the previous quarter, attributed to a decrease in supply rate and costs related to a change in ship management for seven LR2 tankers [5] - The company has strong liquidity with $819 million in cash and cash equivalents as of September 30, 2025, and no meaningful debt maturities until 2030 [6][7] Business Line Data and Key Metrics Changes - The company achieved $83,300 per day on VLCC fleet, $60,600 per day on Suezmax fleet, and $42,200 per day on LR2/Aframax fleet for the third quarter of 2025, showing significant increases compared to the previous year [3] - The average cash-based breakeven rates for the next 12 months are estimated at approximately $26,000 per day for VLCCs, $23,300 for Suezmax tankers, and $23,600 for LR2 tankers [8] Market Data and Key Metrics Changes - Oil in transit has reached record highs, with year-on-year increases in export volumes, particularly from the Americas and the Atlantic Basin [10] - The company noted logistical challenges around the trade of sanctioned export oil, which has been amplified by sanctions on companies like Lukoil and Rosneft [11] - The demand for compliant crudes, especially in the Middle East, has increased, leading to higher crude price levels [12] Company Strategy and Development Direction - The company is focused on maintaining a strong balance sheet while generating cash flow, with a strategy that emphasizes efficient fleet management and capitalizing on market opportunities [6][20] - The management highlighted a shift back to a VLCC-centric trade pattern, driven by positive export numbers from Brazil, Guyana, and Canada [12][20] - The company is cautious about expanding its fleet due to the current market dynamics and is considering focusing on VLCCs for future growth [55] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about the tanker market, citing high utilization rates, strong oil exports, and limited growth in the compliant tanker fleet [20] - The company anticipates a prolonged period of tight physical shipping markets, with key fundamentals supporting continued demand [66] - Management acknowledged the volatility of the market but indicated that current conditions suggest a strong outlook for Q1 2026 [66] Other Important Information - The company has converted existing credit facilities into revolving reducing credit facilities, allowing for greater financial flexibility [7] - The average age of the fleet is seven years, consisting entirely of ECO vessels, with 56% fitted with scrubbers [7] Q&A Session Summary Question: Will the company focus on deleveraging the balance sheet while maintaining dividends? - Management indicated that they are different from peers and prefer not to operate with low loan-to-value ratios, focusing instead on generating cash quickly without aggressive debt reduction [24][25] Question: How do older ships become less efficient without being scrapped? - Management explained that older ships face high insurance costs and limited trading options, making them less efficient in the compliant oil market, which could lead to a wall of scrapping in the future [26][30] Question: What is the outlook for the dark fleet and its impact on the market? - Management noted an increase in vessels sitting idle and discussed potential solutions for recycling sanctioned vessels, indicating that the dark fleet's dynamics are complex and evolving [34][36] Question: How does the current market environment affect vessel demand? - Management highlighted that the current contango in oil pricing could extend trade lanes, positively impacting vessel demand, although they noted that floating storage is not currently a commercial strategy [41][62] Question: What is the outlook for Q1 2026 compared to Q4 2025? - Management expressed confidence that Q1 2026 could sustain strong rates due to favorable market conditions and key drivers that were not present in Q4 of the previous year [66]

Financial Data and Key Metrics Changes - In Q3 2024, the company reported a profit of $40.3 million, or $0.18 per share, with an adjusted profit of $42.5 million, or $0.19 per share, reflecting a decrease of $37.8 million compared to the previous quarter due to lower time charter earnings [4][5] - Time charter earnings fell from $283 million in the previous quarter to $248 million in Q3 2024 [4] - Operating expenses increased by $3.1 million from the previous quarter, attributed to a decrease in supply rates and costs related to ship management changes [5] Business Line Data and Key Metrics Changes - The company achieved daily rates of $34,300 for VLCCs, $35,100 for Suezmax, and $31,400 for LR2/Aframax fleets in Q3 2024 [3] - For Q4 2024, 75% of VLCC days are booked at $83,300 per day, 75% of Suezmax days at $60,600, and 51% of LR2/Aframax days at $42,200 [3] Market Data and Key Metrics Changes - Oil in transit has reached record highs, with export volumes growing, particularly from the Americas and the Atlantic Basin [10] - Year-on-year, Middle Eastern producers' exports increased by 1.2 to 1.3 million barrels per day in October [10] - The company noted logistical challenges in trading sanctioned export oil, particularly affecting Lukoil and Rosneft [10] Company Strategy and Development Direction - The company is optimistic about the tanker market, citing a return to a VLCC-centric trade pattern driven by strong export numbers from Brazil, Guyana, and Canada [12][20] - The order book for tankers is increasing, but the company believes that effective fleet growth will remain muted due to the aging fleet and limited new builds [18][20] - The company aims to focus on VLCCs, which have shown better economic returns compared to other classes [55] Management's Comments on Operating Environment and Future Outlook - Management expressed excitement about the current market developments and the potential for sustained high rates due to limited fleet growth and strong demand for compliant oil [20] - The company anticipates a prolonged period of tightness in the shipping market, with firm refining margins and high utilization rates [20] - Management acknowledged the volatility of the market but noted that key fundamentals are supportive of continued strength [66] Other Important Information - The company has a strong liquidity position with $819 million in cash and cash equivalents and no meaningful debt maturities until 2030 [6] - The average cash-based breakeven rates for the next 12 months are estimated at approximately $26,000 for VLCCs, $23,300 for Suezmax, and $23,600 for LR2 tankers [8] Q&A Session Summary Question: Is the company looking to deleverage the balance sheet while maintaining dividends? - Management indicated that they are not particularly comfortable with low loan-to-value ratios and have been conservative in their financial analysis, focusing on cash generation rather than actively reducing debt [24][25] Question: How do older ships become less efficient without being scrapped? - Management explained that older ships face high insurance costs and limited trading options, making them less efficient in the compliant oil market, which could lead to a gradual reduction in their effective fleet presence without actual scrapping [28][29] Question: What is the outlook for the dark fleet and its impact on the market? - Management noted an increase in vessels sitting idle and discussed potential solutions for recycling sanctioned vessels, indicating that the dark fleet's dynamics are complex and evolving [36][37] Question: How does the current market environment affect vessel demand? - Management highlighted that while there is currently no contango, modest contango could support trade lanes and enhance vessel demand, particularly as oil prices remain firm [41][42] Question: What is the company's view on floating storage demand? - Management clarified that current floating storage is more related to logistics and weather rather than commercial viability, contrasting it with the high demand seen during COVID [61][62] Question: How does the company view Q1 2026 compared to Q4 2025? - Management expressed optimism for Q1 2026, citing strong fundamentals and a tight physical shipping market, although they acknowledged the inherent volatility of the market [66]

Financial Data and Key Metrics Changes - In Q3 2024, the company reported a profit of $40.3 million, or $0.18 per share, with an adjusted profit of $42.5 million, or $0.19 per share, reflecting a decrease of $37.8 million from the previous quarter primarily due to lower time charter earnings [4][5] - Time charter earnings fell from $283 million in the previous quarter to $248 million in Q3 2024 [4] - Operating expenses increased by $3.1 million from the previous quarter, attributed to a decrease in supply rate and costs related to a change in ship management [5] Business Line Data and Key Metrics Changes - The company achieved daily rates of $34,300 for VLCCs, $35,100 for Suezmax, and $31,400 for LR2/Aframax fleets in Q3 2024 [3] - For Q4 2024, 75% of VLCC days are booked at $83,300 per day, 75% of Suezmax days at $60,600, and 51% of LR2/Aframax days at $42,200 [3] Market Data and Key Metrics Changes - Oil in transit has reached record highs, with export volumes increasing, particularly from the Americas and the Atlantic Basin [10] - Year-on-year, Middle Eastern producers' exports are up by 1.2 to 1.3 million barrels per day for October [10] - The company noted logistical challenges around the trade of sanctioned export oil, particularly affecting Lukoil and Rosneft [10] Company Strategy and Development Direction - The company is focusing on maintaining a strong balance sheet and liquidity, with $819 million in cash and cash equivalents as of September 30, 2025 [6] - The fleet consists of 41 VLCCs, 21 Suezmax tankers, and 18 LR2 tankers, all ECO vessels, with a strategy to capitalize on the VLCC-centric trade pattern [6][12] - The company is optimistic about the tanker market's longevity due to limited growth in the compliant tanker fleet and strong oil export fundamentals [20] Management's Comments on Operating Environment and Future Outlook - Management expressed excitement about the current market developments, indicating a positive outlook for the tanker industry [2] - The company anticipates a sustained contango structure in the oil market, which could lead to inventory builds and increased demand for compliant vessels [12][20] - Management highlighted that the tanker market is experiencing high utilization and strong oil exports, with limited growth in the compliant tanker fleet [20] Other Important Information - The company has no meaningful debt maturities until 2030 and no new building commitments, allowing for flexibility in financial management [6] - The average cash-based breakeven rates for the next 12 months are estimated at approximately $26,000 per day for VLCCs, $23,300 for Suezmax, and $23,600 for LR2 tankers [7][8] Q&A Session Summary Question: Is the company looking to deleverage the balance sheet while maintaining dividends? - Management stated that they are different from peers and are not particularly comfortable with low loan-to-value ratios, indicating a conservative approach to financial management [22][24] Question: How do older ships become less efficient without being scrapped? - Management explained that older vessels face high insurance costs and limited trading options, making them less efficient in the compliant oil market [26][29] Question: What is the outlook for the dark fleet and its impact on the market? - Management noted an increasing number of vessels sitting idle and discussed potential solutions for recycling sanctioned vessels [34][36] Question: How does the current market environment affect vessel demand? - Management indicated that the current market is tight, with no signs of weakness, and highlighted key fundamentals supporting the market [65][70] Question: What is the outlook for Q1 compared to Q4? - Management expressed optimism for Q1, citing strong fundamentals that were not present in Q4 of the previous year [66][70]

Third Quarter Presentation Nov 2025 Forward Looking Statements MATTERS DISCUSSED IN THIS DOCUMENT MAY CONSTITUTE FORWARD-LOOKING STATEMENTS. THE PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995 PROVIDES SAFE HARBOR PROTECTIONS FOR FORWARD-LOOKING STATEMENTS IN ORDER TO ENCOURAGE COMPANIES TO PROVIDE PROSPECTIVE INFORMATION ABOUT THEIR BUSINESS. FORWARD-LOOKING STATEMENTS INCLUDE STATEMENTS CONCERNING PLANS, OBJECTIVES, GOALS, STRATEGIES, FUTURE EVENTS OR PERFORMANCE, AND UNDERLYING ASSUMPTIONS AND OTHER STA ...

Please find enclosed the presentation of Frontline plc's third quarter 2025 results to be held on the webcast / conference call 21 November, 2025 at 15:00 CET. This information is subject to the disclosure requirements pursuant to Section 5-12 the Norwegian Securities Trading Act Attachment Presentation Q3 2025 ...