Genmab A/S (NASDAQ:GMAB) ranks among the best high growth European stocks to buy. On January 20, H.C. Wainwright cut its price target for Genmab A/S (NASDAQ:GMAB) to $39 from $41, retaining a Buy rating on the company’s shares. The change comes after Genmab and partner AbbVie announced that their Phase 3 EPCORE DLBCL-1 trial found no meaningful improvement in the overall survival for EPKINLY (epcoritamab) monotherapy when compared to standard treatments in second-line diffuse large B-cell lymphoma (DLBCL) ...

Group 1 - Genmab A/S reported worldwide net trade sales of DARZALEX (daratumumab) totaling USD 14,351 million in 2025, with USD 8,266 million from the U.S. and USD 6,085 million from the rest of the world [1][5] - Genmab receives royalties on the worldwide net sales of DARZALEX, which includes both intravenous and subcutaneous products, under an exclusive license agreement with Johnson & Johnson [1][5] - The company has a strong late-stage clinical pipeline and is focused on delivering transformative antibody-based medicines to patients [2] Group 2 - Established in 1999, Genmab is headquartered in Copenhagen, Denmark, and has a global presence across North America, Europe, and Asia Pacific [3] - Genmab has been dedicated to improving the lives of people with cancer and other serious diseases through innovative antibody medicines for over 25 years [2]

Core Insights - Genmab A/S released topline results from the Phase 3 EPCORE DLBCL-1 trial of epcoritamab for diffuse large B-cell lymphoma (DLBCL), comparing it to standard chemotherapy options [1][2]. Study Details - The global study enrolled 483 patients with at least one prior line of therapy who were ineligible for high-dose chemotherapy and autologous stem cell transplant (HDT-ASCT) [2]. - The trial began in January 2021 and is still ongoing [2]. Data Findings - The study showed an overall survival (OS) hazard ratio of 0.96, which did not reach statistical significance [3]. - Epcoritamab monotherapy demonstrated improvements in progression-free survival (PFS), complete response rate, duration of response, and time to next treatment [3]. Safety Profile - Adverse events observed in the study were consistent with the known safety profile of epcoritamab [4]. - Ongoing analysis will consider various factors, including the impact of the COVID-19 pandemic and the availability of new anti-lymphoma therapies [4]. Future Steps - Full trial results will be presented at a future medical meeting, and Genmab will engage with global regulatory authorities for next steps [5]. - Data from two additional Phase 3 trials evaluating fixed-duration epcoritamab for DLBCL is anticipated in 2026 [5]. - Epcoritamab is already approved as Epkinly in the U.S. and Japan, and as Tepkinly in the European Union [5]. Analyst Commentary - Analysts expressed concerns about the EPCORE DLBCL-1 trial's failure to achieve significant OS results, raising questions about the current r/r DLBCL indication's accelerated approval status [6]. - Confidence remains in the upcoming EPCORE DLBCL-2 trial results in 2026, supported by strong Phase 2 results with Epkinly plus R-CHOP [6]. - Analysts believe it is unlikely that Epkinly will lose its accelerated approval status, citing precedents with other drugs [7]. Market Reaction - Genmab shares were down 2.36% at $31.49 at the time of publication [8].

Group 1 - Genmab A/S is recognized as one of the top oncology stocks to buy, with Deutsche Bank raising its price target for GMAB to DKK 2,400 from DKK 2,000 and maintaining a Buy rating, indicating strong analyst optimism regarding the company's late-stage oncology pipeline [1][3] - The company has partnered with AI research firm Anthropic to enhance its R&D capabilities through the use of agentic AI powered by Claude models, aiming for a more scalable and effective R&D process while maintaining human oversight [2] - Genmab specializes in developing innovative antibody-based therapies for cancer treatment, with its late-stage pipeline featuring promising programs such as Rina-S and Epkinly [3]

Industry Overview - The oncology market in the United States is projected to grow from an estimated $81.34 billion in 2025 to $211.78 billion by 2034, reflecting a compound annual growth rate (CAGR) of 11.75% driven by rising cancer rates and demand for personalized treatments [1] - Targeted treatments and monoclonal antibodies are leading sectors, with monoclonal antibodies expected to account for approximately 30% of market sales in 2024 [2] - Major trends include the integration of artificial intelligence (AI) in predicting patient responses to immunotherapy, with expected accuracy rates of 70%-80% by 2026 [3] Emerging Technologies - The oncology field is increasingly focusing on molecularly defined subsets of cancer, allowing for targeted therapies based on specific mutations rather than organ sites [4] - Therapeutic messenger RNA (mRNA) vaccines are in late-stage clinical trials, with potential approval anticipated between 2027 and 2029 [4] - Innovations such as Antibody-Drug Conjugates (ADCs), Bi-specific T-cell Engagers (TCEs), and non-invasive liquid biopsies are enhancing treatment efficacy and monitoring techniques [3][4] Company Highlights - Genmab A/S (NASDAQ:GMAB) is recognized for its innovative antibody-based therapies and has a promising late-stage oncology pipeline, including programs like Rina‑S and Epkinly [10][12] - Novartis AG (NYSE:NVS) has a robust oncology portfolio with over 30 high-value therapies and is investing in precision oncology and advanced manufacturing, including a new RLT facility in Florida as part of a $23 billion U.S. investment strategy [13][14][15]

Core Insights - Danish drugmaker Genmab's experimental drug for a type of blood cancer did not achieve its primary endpoint in a late-stage clinical trial [1] Company Summary - Genmab announced the failure of its experimental drug in a late-stage study, indicating a setback in its development pipeline [1]

Core Insights - Genmab announced topline results from the Phase 3 EPCORE DLBCL-1 trial, showing that epcoritamab monotherapy improved progression-free survival (PFS) in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) [1][2] - The trial demonstrated an overall survival (OS) hazard ratio of 0.96, which did not reach statistical significance [1] - Genmab and AbbVie will engage with global regulatory authorities to discuss next steps following the trial results [3] Study Details - The EPCORE DLBCL-1 trial enrolled 483 patients with R/R DLBCL, with 73% having received two or more prior lines of therapy [2] - The study compared epcoritamab monotherapy to investigator's choice of chemotherapy regimens, including rituximab plus gemcitabine and oxaliplatin (R-GemOx) or bendamustine plus rituximab (BR) [2][8] - The trial is ongoing and started on January 13, 2021 [8] Safety and Efficacy - Adverse events observed were consistent with the known safety profile of epcoritamab [3] - Further analysis of results is ongoing, considering factors like the COVID-19 pandemic and the availability of new anti-lymphoma therapies [3] Future Trials - Data is expected in 2026 from two additional Phase 3 trials evaluating epcoritamab in different treatment settings for DLBCL [4] - These trials include EPCORE DLBCL-2, assessing epcoritamab in combination with standard-of-care R-CHOP, and EPCORE DLBCL-4, comparing epcoritamab with lenalidomide against chemo-immunotherapy [4][12] Company Commitment - Genmab's CEO emphasized the significance of the EPCORE DLBCL-1 trial results in supporting epcoritamab as a core therapy for B-cell malignancies [5] - Epcoritamab has received regulatory approval in over 65 countries for certain lymphoma indications and is co-developed with AbbVie [5][11]

Group 1 - The article does not provide any relevant content regarding company or industry insights [1]

Core Viewpoint - Genmab is transitioning from a royalty-based company to a fully integrated, innovation-driven biotech firm with a focus on proprietary medicines and a robust late-stage pipeline, positioning itself for sustainable long-term growth into the 2030s [2][3]. Group 1: Company Overview - Genmab has evolved over the past decade, enhancing its portfolio and capabilities [2]. - The company is now characterized by a diversified revenue base and three high-impact late-stage programs [2]. Group 2: Growth Strategy - The company aims to leverage its high-quality revenue base and late-stage portfolio to drive sustainable growth well into the next decade [3].

Genmab Conference Call Summary Company Overview - **Company**: Genmab - **Event**: 2026 J.P. Morgan Healthcare Conference - **Key Speakers**: CEO Jan van de Winkel, CMO Tahamtan Ahmadi, CFO Anthony Pagano Core Industry and Company Insights - Genmab has transitioned from a royalty-based company to a fully integrated, innovation-driven biotech with a growing portfolio of proprietary medicines and a strong late-stage pipeline [2][3] - The company begins 2026 with a diversified revenue base and a late-stage portfolio that can drive sustainable growth into the 2030s, following the acquisition of Merus, which added nine medicines to its market offerings [3][4] - Genmab is financially profitable and continues to invest in priority programs with the highest potential impact for patients [3] Key Programs and Developments - **Epkinly**: A bispecific antibody with dual indications across key B-cell malignancies, showing strong uptake and potential to redefine care in B-cell lymphomas. It has demonstrated phase three superiority over standard care in follicular lymphoma [5][6] - **Rina S**: A folate receptor alpha-targeted ADC with potential to expand eligibility beyond high expressors, currently in three ongoing phase three trials [5][6] - **Petosemtamab**: An EGFR LGR5 bispecific with promising data in head and neck cancer, showing a 63% response rate in first-line settings, significantly higher than standard care [6][7] Financial Projections and Market Strategy - Genmab anticipates multiple registrational data readouts in 2026, setting the stage for important product launches in 2027 [8][9] - The company expects to increase the addressable patient population for Epkinly from approximately 27,000 to nearly 150,000 by early next decade [9] - The peak sales estimate for Rina S has been upgraded from $1 billion to $2 billion due to emerging data and clinical development progress [43] Competitive Landscape and Differentiation - Genmab is focused on executing its development plans rapidly to differentiate its products in a competitive oncology landscape [50] - The company is strategically prioritizing high-impact programs and evaluating partnerships from the Merus acquisition to ensure alignment with its goals [25][27] Operational Efficiency and Future Outlook - Genmab is committed to driving operational efficiencies while expanding its pipeline, particularly in high-priority phase three trials [68][70] - The company aims to leverage its scale to reduce costs and free up capital for further investment in promising programs [71] Additional Insights - The company has a strong track record of delivering on financial and operational commitments, which supports confidence in its future growth [11] - Genmab's focus on antibody science and development expertise aims to translate into meaningful breakthroughs for patients and long-term value for stakeholders [12] This summary encapsulates the key points discussed during the Genmab conference call, highlighting the company's strategic direction, product pipeline, financial outlook, and competitive positioning in the biotech industry.