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Genmab(GMAB) - 2025 Q2 - Earnings Call Presentation
2025-08-07 16:00
Forward looking statement This presentation contains forward looking statements. The words "believe", "expect", "anticipate", "intend" and "plan" and similar expressions identify forward looking statements. All statements other than statements of historical facts included in this presentation, including, without limitation, those regarding our financial position, business strategy, plans and objectives of management for future operations (including development plans and objectives relating to our products), ...
新药周观点:维立新博IPO在即,二代IO产品PD-L1、4-b值得关注-20250720
Guotou Securities· 2025-07-20 06:04
Investment Rating - The report maintains an investment rating of "Outperform" [6] Core Insights - The report highlights that Weili Zhibo is set to officially list on the Hong Kong Stock Exchange on July 25, 2025, with a pipeline of approximately 14 candidate drugs, 6 of which are in clinical development. The core product, the second-generation IO product PD-L1/4-1BB bispecific antibody LBL-024, is currently in a key registration clinical phase for treating lung neuroendocrine tumors [2][18] - The report notes that several PD-L1/4-1BB bispecific antibodies are under development globally, with Genmab's Acasunlimab leading in progress, having initiated a Phase III clinical trial for PD-L1 positive NSCLC in the second line. Weili Zhibo's LBL-024 is also in a critical registration clinical study for lung neuroendocrine tumors [21][22] - Early data from the PD-L1/4-1BB bispecific antibodies indicate that Weili Zhibo's LBL-024 has shown excellent overall response rate (ORR) data in first-line SCLC treatment, while Genmab's Acasunlimab has demonstrated superior survival data in second-line PD-L1 positive NSCLC [26] Summary by Sections Weekly New Drug Market Review - From July 14 to July 20, 2025, the top five companies in the new drug sector by stock price increase were Lepu Biotech (62.0%), Deqi Pharma (47.04%), Kaituo Pharma (41.99%), JAKS (41.95%), and Gilead Sciences (31.15%) [14][16] Weekly New Drug Industry Key Analysis - Weili Zhibo's innovative drug pipeline includes 14 candidate drugs, with 6 in clinical development. The focus is on the PD-L1/4-1BB bispecific antibody LBL-024, which is in a key registration clinical phase for lung neuroendocrine tumors [2][18] Weekly New Drug Approval & Acceptance Status - No new drug or new indication approvals were granted this week, but 6 new drug applications were accepted [3] Weekly New Drug Clinical Application Approval & Acceptance Status - This week, 35 new drug clinical applications were approved, and 28 new drug clinical applications were accepted [4] Domestic Market Key Events TOP3 - Baiyue Shenzhou's application for the injection of Talazotuzumab for treating extensive-stage small cell lung cancer (ES-SCLC) has been accepted [5] Overseas Market Key Events TOP3 - Otsuka Pharmaceutical's APRIL antibody is expected to be included in priority review for treating adult primary immunoglobulin A nephropathy [10]