医药生物行业 行业研究 | 动态跟踪 IO 和 ADC 为焦点，联用将迎突破 ——JPM MNC 肿瘤进展梳理 核心观点 "一代 IO+ADC"和"二代 IO+化疗"均在今年读出 1L 驱动基因阴性 NSCLC 的关 键数据，届时在联用背景下，ADC 相对化疗，以及二代 IO 相对一代 IO 表现如何的 关键问题将得到解答，IO 联合 ADC 的确定性将显著提升。当前，IO 已开展和各种 ADC 的联用方案探索，在二代 IO 布局火热的同时，手握 ADC 产品的丰富程度或者 普适性可能亦是未来胜负的关键。因此，对于 ADC 的需求有望进一步提升。 投资建议与投资标的 风险提示 ⚫ 创新药研发失败的风险；市场竞争加剧的风险；创新药商业化的风险等。 国家/地区 中国 行业 医药生物行业 报告发布日期 2026 年 01 月 28 日 看好（维持） 伍云飞 执业证书编号：S0860524020001 香港证监会牌照：BRX199 wuyunfei1@orientsec.com.cn 021-63326320 | | hujuntao@orientsec.com.cn | | --- | --- | | 胡俊涛 | ...

营收941.93亿美元，同比增长6%——强生这份成绩单稳健的表象下，是一次被动的战略收缩：骨科业务增速跌至1.1%，成为医疗科技板块唯一失速的部 门，公司不得不宣布将DePuy Synthes分拆独立，以挽救整体估值体系。 最新！强生拟分拆骨科业务，又一百亿美元分拆案 相比之下，雅培443.28亿美元的营收体量虽仅为强生一半，却面临着更迫切的转型焦虑：IVD业务同比下滑4.3%，成为唯一失守的阵地。为此，公司豪掷 210亿美元收购Exact Sciences，试图用一场"并购式增长"填补新冠红利消退后的业绩真空。 01 顶级医疗"成绩单"公布 强生：心血管强势、骨科"最弱" 强生2025年全年营收941.93亿美元，同比增长6%， 其中： 创新制药业务： 是公司增长的主要引擎，占全年销售额的 65% 以上， 营 收604.01亿美元，同比增长6%。 医疗科技业务：营收337.92亿美元，同比增长6.1%。心血管业务以89.3亿美元销售额、15.8%的同比增速成为最大亮点，不仅是医疗技术部门中唯一实现 两位数增长的业务单元，更推动整体医疗器械业务迈向新高度。 | Full Year | | | | % Chan ...

中金研究 特朗普自2025年1月再次就任美国总统以来多次表示将采取措施推动美国药价降低，其多项举措与药企直接相关。根据ICER的报告，相比于2022年， 2024年经通胀调整后的新药标价（中位数）提高了24%，新药净价（中位数）提高了51%，药企的定价权依旧强势。总的来讲，我们认为，美国的高药 价与医保支付体系、PBM盈利机制，以及药企的定价权等因素密切相关，当前各方利益博弈之下，特朗普政府药价政策的实际效果与推进节奏存在不 确定性，影响相对有限。 点击小程序查看报告原文 美国医保体系的发展历程及现状 医疗服务成本高，医保覆盖率偏低 美国作为一个没有建立全民公共医保的发达国家，其以私人医疗保险为主体，市场力量为主导的医疗体系是一把双刃剑：一方面，通过市场竞争，将资金 与科技优势转化为医疗技术的发展，进而实现医疗产业的升级；另一方面，也导致当前美国医疗体系呈现出医疗服务成本高，医保覆盖面偏低，且医疗服 务效率有待提高的问题。 图表1：美国总医疗支出及其占GDP比重（1960-2023） 资料来源：CMS，中金公司研究部 ► 医疗服务成本： 在美国医疗总支出中，个人健康护理支出占绝对比重，其中，医院护理、专业医疗 ...

Quadruplet regimen demonstrated significantly deeper and more durable responses, higher MRD negativity and improved progression-free survival versus a standard of care Approval marks the twelfth indication for DARZALEX FASPROо and fifth in the newly diagnosed setting, underscoring its role as foundational therapy for both newly diagnosed and relapsed/refractory multiple myeloma patients о HORSHAM, Pa., Jan. 27, 2026 /PRNewswire/ -- Johnson & Johnson (NYSE:JNJ) announced today the U.S. Food and Drug Administ ...

Core Insights - Johnson & Johnson (J&J) announced a financial outlook for 2026, projecting sales between $100.0 billion and $101.0 billion, surpassing the Zacks Consensus Estimate of $98.5 billion, with adjusted earnings per share expected to be in the range of $11.43 to $11.63 [1][9] Group 1: Innovative Medicine Segment - J&J anticipates accelerated growth in the Innovative Medicine segment in 2026, despite the loss of exclusivity (LOE) for the blockbuster drug Stelara, which negatively impacted growth by 1040 basis points in 2025 [2][3] - Key products such as Darzalex, Tremfya, Spravato, Carvykti, and Erleada, along with new launches like Rybrevant and Caplyta, are expected to drive growth in 2026 [4][5] - The impact of generic competition is expected to increase in 2026 with the introduction of biosimilars for Stelara and generics for Simponi and Opsumit [3][4] Group 2: MedTech Segment - J&J's MedTech business showed improvement with sales rising 4.3% to $33.8 billion in 2025, and stronger growth is expected in 2026 due to increased adoption of new products across various portfolios [6][7] - The company anticipates some challenges from China's volume-based procurement (VBP) program, which is a government-driven cost containment effort [6][7] Group 3: Stock Performance and Valuation - J&J's stock has outperformed the industry, rising 47.3% over the past year compared to a 19.3% increase in the industry [8] - The company's shares are currently trading at a price/earnings ratio of 19.11, higher than the industry average of 18.33 and above its five-year mean of 15.65 [11] - The Zacks Consensus Estimate for 2026 earnings has increased from $11.46 to $11.53, reflecting a positive outlook following J&J's financial projections [13]

NEW BRUNSWICK, N.J.--(BUSINESS WIRE)--Johnson & Johnson, with support from the Johnson & Johnson (J&J) Foundation, announced that it has donated $100 million of MedTech products since 2020 to help more people around the world access the specialized care they need to live, see and smile. The Company has also planned to contribute an additional $20 million toward programs and impact investments that empower health workers to deliver cardiac, vision and surgical care in their communiti. ...

Core Viewpoint - Johnson & Johnson (NYSE: JNJ) is recognized as a strong investment opportunity, particularly highlighted by Guggenheim's positive outlook following solid Q4 results and favorable 2026 guidance [2][4]. Financial Performance - Guggenheim analyst Vamil Divan raised the price target for Johnson & Johnson to $240 from $227, maintaining a Buy rating after the company reported solid fourth-quarter results [2]. - The company’s fourth-quarter earnings for 2025 were released on January 21, accompanied by a 2026 outlook that exceeded Wall Street expectations [4]. - Johnson & Johnson forecasts 2026 sales between $99.5 billion and $100.5 billion, surpassing analyst expectations of approximately $98.9 billion [5]. Adjustments and Forecasts - Following the quarter, Divan adjusted his model, increasing near-term forecasts for Tremfya and raising estimates for several newer products, while also factoring in faster erosion for Stelara [3]. - Despite challenges such as a drug pricing agreement with the Trump administration and approximately $500 million in tariff-related costs, the company’s guidance remained robust [4][5]. Business Segments - Johnson & Johnson operates in the healthcare sector through its Innovative Medicine and MedTech segments, which include drug development and medical devices [6].

Core Viewpoint - Johnson & Johnson (NYSE: JNJ) has provided a strong 2026 outlook, surpassing Wall Street expectations despite facing significant challenges, including a drug pricing agreement and tariff-related costs [2][3]. Financial Performance - For 2026, Johnson & Johnson anticipates sales between $99.5 billion and $100.5 billion, exceeding analyst projections of approximately $98.9 billion [3]. - The company expects full-year earnings per share to be in the range of $11.43 to $11.63, slightly above the consensus estimate of $11.45 [3]. Management Outlook - CEO Joaquin Duato expressed optimism during the earnings call, indicating that the company expects to achieve faster growth in 2026 compared to 2025 and aims for double-digit growth by the end of the decade [4]. Business Operations - Johnson & Johnson operates across the healthcare sector, developing and selling a diverse range of products, including pharmaceuticals and medical devices [4]. Challenges - The drug pricing agreement with the Trump administration is projected to cost the company "hundreds of millions of dollars," alongside an expected $500 million in tariff-related costs impacting its medical devices segment [2][3].

【国泰海通医药】强生制药JNJ 2025年业绩梳理 强生制药2025年业绩达成目标，2026年及之后增长或更加强劲（ 向于小型早期BD）。 JNJ 2025年收入942亿美金，yoy+6%，相较于3Q25上调后的全年指引5.7%增长继续超额达成目标。 净利润268亿，调整后的EPS为10.79美金，yoy+8.1%，EPS是3Q25指引8.2-9.2%增长的下限。 20 【国泰海通医药】强生制药JNJ 2025年业绩梳理 强生制药2025年业绩达成目标，2026年及之后增长或更加强劲（ 向于小型早期BD）。 JNJ 2025年收入942亿美金，yoy+6%，相较于3Q25上调后的全年指引5.7%增长继续超额达成目标。 净利润268亿，调整后的EPS为10.79美金，yoy+8.1%，EPS是3Q25指引8.2-9.2%增长的下限。 2026年公司给出了6.2%收入增长以达到1000亿美金的目标； 现金流强劲，将用于回购、分红和BD收并购。 2025年强劲的基本面带来197亿自由现金流，目前公司拥有200亿美金的现金资产，以及480亿美金债务。 2026年其他可关注的催化剂。 2026年公司计划进一步增强现金流 ...

Kurt Arnold and Jason Itkin, co-founders of elite Texas law-firm Arnold & Itkin LLP, are in the limelight since Kurt Arnold's wife died in a deadly plane crash. Tara Arnold, the 46-year-old attorney wife met a fatal accident when a private jet flipped over and burst into flames at a Maine airport, killing 6 on Sunday. Let's find out all about the owners of the Houston law firm allegedly linked with the mishap.Arnold & Itkin Law is a trial law firm based in Texas' Houston, which is nationally recognized. Spe ...