香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 對 因 本 公 告 全部或任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責 任。 JOINN LABORATORIES (CHINA) CO., LTD. 北京昭衍新藥研究中心股份有限公司 （於 中 華 人 民 共 和 國 註 冊 成 立 的 股 份 有 限 公 司） （股 份 代 號：6127） 本公告乃北京昭衍新藥研究中心股份有限公司（「本公司」）根據香港聯合交易 所有限公司證券上市規則第13.10B條 而 作 出。 茲 載 列 本 公 司 於 上 海 證 券 交 易 所 網 站 刊 登 公 告 如 下，僅 供 參 閱。 承董事會命 北京昭衍新藥研究中心股份有限公司 馮宇霞 董事長 中 國 北 京，2025年7月29日 於 本 公 告 日 期，董 事 會 包 括 主 席 兼 執 行 董 事 馮 宇 霞 女 士、執 行 董 事 高 大 鵬 先 生、孫雲霞女士、羅樨女士及顧靜良先生，及獨立非執行董事張帆先生、楊福全 先 生、陽 ...

经济观察网 昭衍新药（603127）公告，公司股票于2025年7月25日、7月28日和7月29日连续3个交易日 内日收盘价格涨幅偏离值累计超过20%，属于股票交易异常波动情形。经公司自查并书面征询公司控股 股东及实际控制人，确认不存在应披露而未披露的重大信息。公司生产经营活动正常，内、外部经营环 境未发生重大变化，不存在影响公司股票交易价格异常波动的应披露而未披露的重大信息。 ...

Group 1 - The Hong Kong pharmaceutical outsourcing sector has strengthened, with companies such as Kanglong Chemical (03759.HK) and WuXi AppTec (02359.HK) rising over 3% [1] - Other companies like Zhaoyan New Drug (06127.HK) and Tiger Med (03347.HK) also experienced gains [1]

Company Overview - Zhao Yan New Drug closed at 32.0 yuan, up 7.02%, with a rolling PE ratio of 61.91, the lowest in 488 days, and a total market value of 23.983 billion yuan [1] - The company specializes in non-clinical safety evaluation services for drugs, preclinical research services, and sales of laboratory animals and related products [1] Financial Performance - For Q1 2025, the company reported revenue of 287 million yuan, a year-on-year decrease of 11.54%, while net profit was 41.1195 million yuan, a year-on-year increase of 115.11%, with a gross margin of 28.61% [1] Shareholder Information - As of September 30, 2020, the number of shareholders was 17,882, a decrease of 783 from the previous period, with an average holding value of 352,800 yuan and an average holding quantity of 27,600 shares [1] Industry Comparison - The average PE ratio for the medical services industry is 48.04, with a median of 58.89, placing Zhao Yan New Drug at 30th in the industry ranking [1][2] - The static PE ratio for Zhao Yan New Drug is 32.77, with a price-to-book ratio of 2.96 [2]

Core Viewpoint - The stock of Zhaoyan New Drug closed at 27.33 yuan, up 6.43%, with a rolling PE ratio of 52.87, marking a new low in 405 days, and a total market capitalization of 20.483 billion yuan [1]. Group 1: Company Performance - As of the first quarter of 2025, Zhaoyan New Drug reported revenue of 287 million yuan, a year-on-year decrease of 11.54%, while net profit reached 41.12 million yuan, a year-on-year increase of 115.11%, with a gross profit margin of 28.61% [1]. - The company specializes in non-clinical safety evaluation services for drugs, preclinical research services, and sales of laboratory animals and related products [1]. Group 2: Market Position - Zhaoyan New Drug's PE ratio of 52.87 is higher than the industry average of 45.40 and the industry median of 52.21, ranking 30th among its peers [2]. - A total of 17 institutions hold shares in Zhaoyan New Drug, with a combined holding of 10.9687 million shares valued at 231 million yuan [1].

Group 1 - The CXO sector is experiencing a strong rebound, with notable gains in companies such as Zhaoyan New Drug (up over 8%) and Kanglong Chemical (up over 6%) [1][3] - A-share's largest medical ETF (512170) reached a nearly 4-month high, with trading volume exceeding 400 million yuan within the first 30 minutes of trading [1] - Several leading CXO companies have reported positive mid-year earnings forecasts, with Zhaoyan New Drug expecting a net profit increase of up to 144% and WuXi AppTec also projecting over 100% growth [3][4] Group 2 - Institutional interest in the healthcare sector remains high, particularly in pharmaceutical and biotechnology industries, with a focus on CXO services and humanoid robotics [4] - China International Capital Corporation (CICC) highlights the improved financing environment for innovative drugs, positively impacting orders for domestic CROs and upstream research services [5] - CICC recommends focusing on CXO and medical devices, as well as the largest medical ETF (512170) and the first domestic drug ETF (562050), which targets leading pharmaceutical companies [5]

Investment Rating - The report initiates coverage with a "Strong Buy" investment rating for the company [1]. Core Insights - The company, Zhaoyan New Drug, is positioned as a leader in the domestic CRO industry, particularly in safety evaluation, with comprehensive GLP qualifications and strategic resources in experimental monkeys. The company is expected to benefit from rising prices of experimental monkeys due to supply constraints and strong demand [1][8]. - The report highlights the mismatch between supply and demand for experimental monkeys, which is driving a price recovery trend. The aging population of breeding monkeys and the long breeding cycle are significant factors affecting supply [2][8]. - The company is expanding its offshore outsourcing business, which is anticipated to create a new growth engine, alongside the recovery of domestic demand [8][42]. Financial Data and Valuation - The projected financial performance shows total revenue decreasing from 2,377 million in 2023 to 1,977 million in 2025E, with a subsequent recovery to 2,468 million by 2027E. The net profit is expected to rebound significantly from 74 million in 2024 to 352 million in 2025E [3][4]. - The company’s PE ratio is projected to be 39.8 in 2025E, decreasing to 24.4 by 2027E, indicating an improving valuation as earnings recover [3][4]. Supply and Demand Dynamics - The supply of experimental monkeys is constrained due to an aging population and a long breeding cycle, with over 80% of breeding females being over 8 years old as of 2023. This has led to a significant decline in breeding rates [8][19]. - Demand for experimental monkeys is expected to improve, particularly for biopharmaceutical research, as over 70% of large molecule drugs require monkeys for preclinical trials [26][28]. Strategic Initiatives - The company has made strategic acquisitions, including monkey breeding facilities, to enhance its supply chain and reduce costs, thereby increasing profitability [8][60]. - The offshore outsourcing strategy is showing positive results, with higher gross margins from overseas orders, which is expected to enhance overall profitability [52][54]. Management and Governance - The management team has extensive experience in drug safety evaluation and a solid governance structure, with key figures holding significant shares in the company [36][40].

Group 1 - The A-share CRO (Contract Research Organization) sector experienced a significant rally in the afternoon, with notable stocks such as Chengdu Xian Dao hitting the daily limit up [1] - MediXy and Hite Bio both surged over 14%, indicating strong investor interest and market momentum [1] - Other companies in the sector, including Zhaoyan New Drug, Yinuosi, Sunshine Nuohe, Kanglong Huacheng, and Puris, also saw positive gains, reflecting a broader trend in the CRO market [1]

Core Viewpoint - The CSI 1000 Healthcare Index has shown significant growth, with a 4.34% increase over the past month, 12.39% over the last three months, and 16.26% year-to-date [1] Group 1: Index Performance - The CSI 1000 Healthcare Index is currently at 12,486.30 points [1] - The index is based on a sample of liquid and representative securities from each industry, providing diverse investment options [1] Group 2: Index Holdings - The top ten weighted stocks in the CSI 1000 Healthcare Index include: - Zai Lab (3.14%) - Tonghua Golden Horse (3.02%) - Borui Pharmaceutical (2.67%) - Zuoli Pharmaceutical (1.69%) - Rongchang Biologics (1.59%) - Zhaoyan New Drug (1.47%) - Yipinhong (1.44%) - Anke Biologics (1.42%) - Zhongsheng Pharmaceutical (1.42%) - Yifan Pharmaceutical (1.38%) [1] - The index's market distribution shows that the Shanghai Stock Exchange accounts for 55.72%, while the Shenzhen Stock Exchange accounts for 44.28% [1] Group 3: Industry Composition - The industry composition of the CSI 1000 Healthcare Index is as follows: - Chemical drugs: 35.86% - Medical devices: 19.60% - Traditional Chinese medicine: 17.00% - Biological drugs: 14.32% - Medical commerce and services: 7.53% - Pharmaceutical and biotechnology services: 5.69% [2] - The index samples are adjusted biannually, with adjustments occurring on the next trading day after the second Friday of June and December [2]

Core Viewpoint - The company is expected to achieve a turnaround in net profit for the first half of 2025, despite a decline in revenue compared to the previous year [2][4]. Financial Performance Summary - The estimated operating revenue for the period from January to June 2025 is approximately RMB 635.15 million to RMB 702.00 million, representing a decrease of about RMB 147.35 million to RMB 214.21 million, or a year-on-year decline of approximately 17.3% to 25.2% [2][4]. - The estimated net profit attributable to shareholders for the same period is expected to be around RMB 50.32 million to RMB 75.49 million, indicating a return to profitability compared to a loss in the previous year [2][4]. - The estimated net profit attributable to shareholders after deducting non-recurring gains and losses is projected to be approximately RMB 18.83 million to RMB 28.25 million [2][4]. Previous Year Comparison - In the same period last year, the company reported operating revenue of RMB 849.36 million [10]. - The net profit attributable to shareholders was a loss of RMB 169.74 million, with a net loss of RMB 198.39 million after deducting non-recurring gains and losses [11]. - The previous year's net profit from laboratory services was a loss of RMB 15.24 million, while the loss from changes in the fair value of biological assets was RMB 235.36 million [11]. Performance Drivers - The decline in revenue is attributed to increased competition in the industry, which has compressed profit margins and led to a decrease in net profit from laboratory services [13]. - Positive contributions to performance are expected from the fair value changes of biological assets, which have not experienced significant market fluctuations during the reporting period [13].