Availability of the Q1 2025 Aide mémoire Paris, France – March 24, 2025. Sanofi announced today that its Q1 2025 Aide mémoire is available on the "Investors" page of the company's website: First quarter 2025 (sanofi.com) As for each quarter, Sanofi prepared this document to assist in the financial modelling of the Group's quarterly results. This document includes a reminder on various non-comparable items and exclusivity losses as well as the foreign currency impact and share count. Sanofi's first quarter ...

One stock that might be an intriguing choice for investors right now is Banco Santander (SAN) . This is because this security in the Banks - Foreign space is seeing solid earnings estimate revision activity, and is in great company from a Zacks Industry Rank perspective.This is important because, often times, a rising tide will lift all boats in an industry, as there can be broad trends taking place in a segment that are boosting securities across the board. This is arguably taking place in the Finance spac ...

Sanofi to acquire Dren Bio’s bispecific myeloid cell engager for deep B-cell depletion, broadening immunology pipeline Dren Bio deep B-cell depleter program has the potential to reset the immune systemAcquisition underpins path for Sanofi becoming leading immunology companySanofi to pay $600 million up front Paris, March 20, 2025. Sanofi and Dren Bio, Inc., a private clinical-stage biopharmaceutical company, have entered into a definitive agreement under which Sanofi has agreed to acquire DR-0201, a targete ...

The British unit of Spanish lender Banco Santander on Wednesday said 750 of its staff were at risk of redundancy as it targets 95 branch closures in the U.K.The decision is part of the bank's broader plans to update its presence from June 2025 and will bring Santander UK's network to 349 branches, including 290 that are full-service, 36 operating with reduced hours and 18 that are counter-free and five Work Cafes."Closing a branch is always a very difficult decision and we spend a great deal of time assessi ...

Core Insights - Dupixent (dupilumab) has shown positive results in a pivotal phase 2/3 study for treating moderate-to-severe bullous pemphigoid (BP), a chronic skin disease characterized by intense itch and blisters [2][3][6] - The study demonstrated that Dupixent significantly improved disease remission rates and reduced disease severity compared to placebo [6][7] Study Details - The ADEPT study enrolled 106 adults with moderate-to-severe BP, randomized to receive Dupixent 300 mg every two weeks or placebo, alongside standard-of-care oral corticosteroids [3][9] - Sustained disease remission was defined as complete clinical remission with no relapse and no rescue therapy use during the 36-week treatment period [10] Efficacy Results - 20% of Dupixent-treated patients achieved sustained disease remission at 36 weeks compared to 4% in the placebo group (p=0.0114) [7] - 40% of patients on Dupixent experienced a ≥90% reduction in disease severity compared to 10% for placebo (p=0.0003) [7] - Dupixent also led to a significant reduction in oral corticosteroid use, with an average reduction of 1678 mg in cumulative exposure (p=0.0220) [7] Safety Profile - Adverse event rates were similar between Dupixent (96%) and placebo (96%) groups, with no deaths reported in the Dupixent group [4] - Common adverse events associated with Dupixent included peripheral edema, arthralgia, and blurred vision [4] Regulatory Status - The FDA has accepted a supplemental biologics license application for Dupixent to treat BP, with a decision expected by June 20, 2025 [4][6] - Dupixent has received orphan drug designation for BP, indicating its potential as a treatment for a rare disease affecting fewer than 200,000 people in the US [4] Background on Bullous Pemphigoid - BP is a chronic, debilitating skin disease primarily affecting the elderly, characterized by intense itch and painful lesions [8] - Approximately 27,000 adults in the US suffer from uncontrolled BP despite systemic corticosteroid treatment [8] About Dupixent - Dupixent is a fully human monoclonal antibody that inhibits interleukin-4 and interleukin-13 signaling pathways, targeting type 2 inflammation [11] - It has received regulatory approvals in over 60 countries for various indications, with more than one million patients treated globally [12]

Sanofi successfully prices EUR 1.5 billion of bond issue Paris, March 5, 2025. Sanofi announces that it has successfully priced its offering of EUR 1.5 billion of notes across 2 tranches: €850 million floating rate notes, due March 2027, bearing interest at 3-month Euribor plus 0.300%€650 million fixed rate notes, due March 2031, bearing interest at an annual rate of 2.750%. The notes are being issued off the company's Euro Medium Term Note Program. Sanofi intends to use the net proceeds of the offering f ...

Group 1 - Banco Santander (Brasil) S.A. filed its Annual Report on Form 20-F for the year 2024 with the U.S. SEC and the Brazilian CVM on February 28, 2025 [1] - The 20-F report includes certifications under the U.S. Sarbanes-Oxley Act, confirming the effectiveness of Santander Brasil's internal controls and procedures [2] - Independent auditors PricewaterhouseCoopers Auditores Independentes Ltda. provided an audit opinion on the financial statements and internal controls as of December 31, 2024 [2] Group 2 - Shareholders of Santander Brasil can request a hard copy of the 20-F document, which includes complete audited financial statements, free of charge [3]

Core Viewpoint - Banco Santander (NYSE: SAN) has shown strong performance with a ~26% total return for its American Depositary Shares (ADSs) since the last update in October, driven by robust fourth quarter results and optimistic guidance for FY2025 [1] Group 1 - The fourth quarter results of Banco Santander were robust, contributing to the strong performance of its shares [1] - The company provided bullish guidance for FY2025, indicating positive future expectations [1]

Core Insights - New data from the RELIEVE UCCD phase 2b study indicates that duvakitug shows significant potential as a treatment for ulcerative colitis (UC) and Crohn's disease (CD), with promising clinical remission and endoscopic response rates compared to placebo [1][6][9] Ulcerative Colitis (UC) Findings - In the UC cohort, 36% of patients on the 450 mg dose and 48% on the 900 mg dose achieved clinical remission at week 14, compared to 20% on placebo, with placebo-adjusted rates of 16% and 27% respectively [2][4] - Higher clinical remission rates were observed in both advanced therapy (AT)-experienced and AT-naïve subgroups [3][7] Crohn's Disease (CD) Findings - In the CD cohort, 26% of patients on the 450 mg dose and 48% on the 900 mg dose achieved endoscopic response at week 14, compared to 13% on placebo, with placebo-adjusted rates of 13% and 35% respectively [5][8] - Similar to UC, higher endoscopic response rates were noted in both AT-experienced and AT-naïve subgroups [5][8] Safety Profile - Duvakitug was generally well tolerated in both UC and CD cohorts, with no emergent safety signals or dose-dependent adverse events reported [9][10] Study Design and Objectives - The RELIEVE UCCD study was a 14-week, randomized, double-blinded, dose-ranging trial aimed at assessing the efficacy, safety, pharmacokinetics, and tolerability of duvakitug in adults with moderate-to-severe UC or CD [11][12] - The study included a diverse patient population across multiple regions, including the US, Europe, Israel, and Asia [13] Future Development - The findings from the RELIEVE UCCD study will inform a phase 3 program anticipated to start in the second half of 2025, indicating a commitment to further investigate the efficacy and safety of duvakitug [6][16]

Group 1 - Sanofi has filed its 2024 U.S. Form 20-F and French "Document d'Enregistrement Universel" containing the Annual Financial Report [1] - These documents are accessible on Sanofi's website and the websites of the SEC and AMF [1] - A hard copy of the financial statements can be requested free of charge [1] Group 2 - Sanofi is an innovative global healthcare company focused on improving lives through scientific advancements [2] - The company operates in approximately 100 countries and aims to transform medical practices [2] - Sanofi provides life-changing treatments and vaccines while prioritizing sustainability and social responsibility [2]