Core Insights - Structure Therapeutics (NASDAQ: GPCR) ended 2025 positively, with shares rising significantly in December following strong mid-stage data for its weight loss drug, aleniglipron. The company aims to maintain this momentum into 2026 as it progresses in the anti-obesity market [1][7]. Pipeline Overview - Aleniglipron is a once-daily oral GLP-1 candidate that demonstrated a placebo-adjusted mean weight loss of 11.3% at the highest dose in a 36-week phase 2b study. An ongoing mid-stage study has shown even higher mean weight loss of up to 15.3% after 36 weeks. The discontinuation rate due to adverse reactions was 10.4% in the first study, which is typical for GLP-1 medications [4][5]. - Structure Therapeutics plans to initiate a phase 3 study for aleniglipron this year. Additionally, the company has other candidates in its pipeline, including ACCG-2671, an oral weight loss candidate that mimics the action of the amylin hormone [5]. Market Competition - Aleniglipron faces competition from at least two other oral weight loss medications expected to be approved by the time it reaches the market. The FDA has recently approved an oral formulation of Wegovy and is reviewing orforglipron, another oral medicine developed by Eli Lilly [6][7].

Core Viewpoint - Eli Lilly has demonstrated strong momentum due to its current portfolio and upcoming catalysts, maintaining a bright outlook despite recent market fluctuations [1][2]. Financial Performance - Eli Lilly's tirzepatide, marketed as Mounjaro and Zepbound, is significantly contributing to the company's revenue, generating $24.8 billion in sales through the first nine months of 2025, surpassing Keytruda as the world's best-selling medicine [3][4]. - Analysts project that tirzepatide could achieve nearly $62 billion in sales by 2030, indicating sustained growth potential [4]. Market Position and Competition - Eli Lilly faces increasing competition in the weight management sector, particularly from Novo Nordisk, Amgen, and Pfizer, but has produced superior clinical trial results [6]. - The company is advancing orforglipron, an oral weight loss candidate, which is expected to receive expedited regulatory review, potentially enhancing its market position [7]. - Eli Lilly's retatrutide has shown unprecedented results in weight loss during clinical trials, further solidifying its leadership in the anti-obesity market [8]. Valuation and Growth Potential - Eli Lilly's stock is currently trading at 33 times forward earnings, higher than the healthcare sector average of 18.2, but this premium is justified by its robust revenue and earnings growth [9]. - The company's price/earnings-to-growth ratio stands at 0.98, indicating it may be undervalued relative to its growth prospects [9]. - Overall, Eli Lilly is positioned for excellent near- and mid-term prospects, making it a potentially attractive investment for 2026 and beyond [10].

The booming GLP-1 space was built on weekly injections. In 2026, new obesity pills will push the market into its next chapter.Patients are already getting their hands on the first GLP-1 pill for obesity from Danish drugmaker Novo Nordisk — a once-daily drug that shares the same brand name as its popular injection Wegovy. A GLP-1 pill from the company's chief rival Eli Lilly isn't far behind, with a U.S. approval expected within months. For some people, pills may serve as a more convenient — and potentially ...

Heidi Overton, Novo Nordisk CEO Maziar Mike Doustdar, Eli Lilly CEO David A. Ricks, and U.S. Secretary of Commerce Howard Lutnick listen while U.S. President Donald Trump announces a deal with Eli Lilly and Novo Nordisk on to reduce the prices of GLP-1 weight‑loss drugs during an event in the Oval Office at the White House in Washington, D.C., U.S. Nov. 6, 2025.A version of this article first appeared in CNBC's Healthy Returns newsletter, which brings the latest health-care news straight to your inbox. Subs ...

Key Takeaways JNJ agreed to match U.S. drug prices under Trump's MFN plan and received a tariff exemption.JNJ is advancing a $55B plan to expand U.S. manufacturing, research and technology by early 2029.JNJ is building new U.S. facilities in Pennsylvania and North Carolina, including a $2B biologics plant.Johnson & Johnson (JNJ) recently signed a landmark agreement with the Trump administration to lower drug prices in the United States.Following this deal, JNJ joins several other large-cap pharma companies ...

Key Takeaways VKTX enrolled about 180 adults in a phase I maintenance study evaluating VK2735 after initial weight loss.VKTX is testing several SC and oral dosing regimens to assess safety, tolerability and pharmacokinetics.VKTX is also evaluating VK2735 in two phase III studies, with obesity data from both studies expected in 2027.Viking Therapeutics (VKTX) announced that it has completed enrolling patients in its exploratory maintenance dosing study of VK2735, the company's dual agonist of the GLP-1 and G ...

8 January 2026 | 5:01AM EST Equity Research Americas Healthcare: Biotechnology: Constructive backdrop for 2026 Following strong performance for the sector exiting 2025 (XBI +35% vs. S&P 500 +16%), driven by the convergence of a number of key factors, notably, broader market dynamics (e.g., macro/AI-trade rotations and rates), easing policy risks (e.g., Most-Favored-Nations (MFN) drug pricing deals), and improving fundamentals (e.g., stable/upward large-cap estimate revisions and SMID catalyst execution), we ...

由于估值具有吸引力、BD（业务发展）与IPO活动回暖，以及密集的核心催化剂点位，生物制药板块在2026年正展现出强劲的增长潜力。尽管该 行业的整体营收和盈利增长预期略低于市场平均水平，但其低风险属性与强大的管线期权价值，使其成为投资者平衡科技股配置的理想替代方 案。 据追风交易台消息，花旗分析师Jarwei Fang团队6日发布研究报告，认为2025年美国生物制药板块表现不俗，成功打破了连续两年的低迷。其中纳 斯达克生物技术指数（NBI）上涨32%，标准普尔医药指数（DRG）上涨20%，均跑赢标普500指数17%的涨幅。随着政策不确定性在2025年下半 年逐步消除，市场情绪已从防御转向进攻。 目前，大盘制药股的预测市盈率仍低于标普500指数，显示出估值修复空间。花旗预计，美联储在2026年可能进一步降息，将为生物制药板块提供 宏观利好。特别是高增长的领头羊企业如礼来、Gilead和Vertex，有望凭借强劲的商业化执行力继续跑赢大盘。 生物制药行业的增长逻辑正在发生深刻变化。GLP-1药物的市场渗透从糖尿病、肥胖症向心血管及神经系统领域外溢；人工智能在药物研发与临 床实验设计中的应用进入收获期；加之DTP（直 ...

2026.01. 06 本文字数：832，阅读时长大约1分钟 作者 | 第一财经 钱童心 当地时间1月5日，诺和诺德的GLP-1减重药司美格鲁肽口服版正式在美国上市，这距离美国FDA批准 该疗法仅两周。 当天美股收盘，诺和诺德股价大涨超过5%，竞争对手礼来股价下跌3.6%。 对自费患者，口服版司美格鲁肽减重药每月治疗费用根据剂量不同，从149美元到299美元不等。这 相较于司美格鲁肽注射剂上市之初每月约1000美元的治疗费用大幅下调。 口服司美格鲁肽减重药起始剂量为1.5毫克，自费患者每月支付149美元；4毫克剂量在4月15日之前 也将以每月149美元的价格出售，之后价格将涨至每月199美元；9毫克和25毫克剂量每月费用为299 美元。 诺和诺德的司美格鲁肽口服减重药需每日服用一片。美国FDA于2025年12月22日批准该药物上市。 美国FDA还批准了司美格鲁肽口服减重药用于降低肥胖且已确诊心血管疾病的成年人发生重大心血 管事件的风险。 在一项针对300多名肥胖但非糖尿病成年人的三期临床试验中，诺和诺德口服司美格鲁肽最高剂量组 的患者在服药64周后平均减重高达16.6%，平均减重13.6%。 与此同时，礼来的 ...

口服司美格鲁肽减重药起始剂量为1.5毫克，自费患者每月支付149美元；4毫克剂量在4月15日之前也将 以每月149美元的价格出售，之后价格将涨至每月199美元；9毫克和25毫克剂量每月费用为299美元。 诺和诺德的司美格鲁肽口服减重药需每日服用一片。美国FDA于2025年12月22日批准该药物上市。美国 FDA还批准了司美格鲁肽口服减重药用于降低肥胖且已确诊心血管疾病的成年人发生重大心血管事件的 风险。 在一项针对300多名肥胖但非糖尿病成年人的三期临床试验中，诺和诺德口服司美格鲁肽最高剂量组的 患者在服药64周后平均减重高达16.6%，平均减重13.6%。 与此同时，礼来的口服GLP-1减重药也已进入上市的最后冲刺阶段。礼来预计，该公司的口服减重疗法 orforglipron有望于今年第一季度获批。临床数据显示，使用最高剂量orforglipron（36mg）可平均减重 10.5%。 口服减重疗法是各大减重药厂商努力争夺的下一个战场。高盛分析预计，口服药物有望在2030年占据全 球减重疗法市场24%的份额，以减重药整体约950亿美元的规模来计算，口服减重药市场规模约合220亿 美元。其中，礼来的口服药预计能 ...