Lilly's Olumiant (baricitinib) recommended by CHMP for approval of expanded use in the European Union for adolescents with severe alopecia areata
Prnewswire· 2026-02-27 13:11
Core Viewpoint - Eli Lilly's Olumiant (baricitinib) has received a positive opinion from the European Medicines Agency's CHMP for expanded use in adolescents aged 12 to under 18 with severe alopecia areata, based on promising data from the Phase 3 BRAVE-AA-PEDS study [1][2]. Group 1: Clinical Study Results - The Phase 3 BRAVE-AA-PEDS study showed that 42.4% of adolescents treated with Olumiant achieved 80% or more scalp hair coverage at 36 weeks, compared to 4.5% in the placebo group [1]. - Near-complete scalp hair coverage (90%) was achieved by 36.5% of patients on Olumiant, while only 2.3% of those on placebo reached this level [1]. - Significant eyebrow regrowth was observed in 50% of patients on Olumiant, compared to 0% in the placebo group [1]. - Eyelash regrowth was reported in 42.9% of patients treated with Olumiant, versus 14.0% in the placebo group [1]. Group 2: Regulatory and Market Implications - The positive CHMP opinion is a step towards European regulatory approval, with a decision from the European Commission expected in the next one to two months [1]. - Lilly has also submitted Olumiant for approval in the U.S. for treating severe alopecia areata in adolescents, with a decision anticipated in the second half of 2026 [1][2]. - Olumiant is already approved for adult patients with severe alopecia areata in the U.S. and Europe, marking it as the first JAK inhibitor approved for this indication [1][2]. Group 3: Safety and Efficacy Profile - The safety profile of Olumiant in adolescents aligns with previous clinical trials for other conditions, such as juvenile idiopathic arthritis and atopic dermatitis [1]. - Over 14,600 patients have participated in clinical trials involving Olumiant, with more than 1,200 being children and adolescents [1]. - The ongoing BRAVE-AA-PEDS trial includes a cohort of children aged 6 to under 12 years, further expanding the understanding of Olumiant's safety and efficacy in younger populations [1].
Proposal of the Shareholders’ Nomination Committee on the Composition and Remuneration of the Board of Directors of Oma Savings Bank Plc
Globenewswire· 2026-02-27 13:10
Core Proposal - The Shareholders' Nomination Committee proposes to elect eight members to the Board of Directors of Oma Savings Bank Plc, increasing from seven members in 2025 [1] - Current Board members Juhana Brotherus, Irma Gillberg-Hjelt, Jaakko Ossa, Carl Pettersson, Kati Riikonen, and Juha Volotinen are proposed for re-election [1] - Eeva Ahdekivi and Jens Jensen are proposed as new members of the Board [2] Board Member Details - Eeva Ahdekivi has extensive experience in investment banking and has held various significant roles, including Chief Investment Officer at Solidium and CEO of Hartwall Capital [3] - Jens Jensen is the CEO of Suvia Group Oy and has a background in leading service and insurance operations, previously serving in management positions at several companies [4] Remuneration Proposal - The proposed annual fees for Board members are as follows: Chair of the Board: EUR 85,000, Vice Chair: EUR 60,000, Other members: EUR 40,000 [5] - Additional annual fees for committee chairs are: Remuneration Committee: EUR 6,000, Risk Committee: EUR 9,000, Audit Committee: EUR 9,000 [6] - Meeting fees are proposed at EUR 1,000 for Board and committee meetings, and EUR 500 for email meetings [6] - 25% of annual fees will be paid in shares of Oma Savings Bank Plc, with the remainder in cash, and the company will cover the costs of acquiring shares [6] Additional Information - The Shareholders' Nomination Committee will cover travel expenses and other direct costs related to Board work [7] - The committee is chaired by Raimo Härmä, with members appointed by various savings bank foundations [8] - Oma Savings Bank Plc is a solvent and profitable Finnish bank, providing services through 48 branches and digital channels to over 200,000 customers [9] - The bank focuses on retail banking and aims to provide a premium customer experience through personal service [10]
One Big Reason Nvidia's Stock Is Stuck In The Mud: Lack Of Direct Shareholder Rewards
Seeking Alpha· 2026-02-27 13:10
分组1 - NVIDIA reported a strong quarterly performance, exceeding both revenue and earnings expectations, and provided guidance that surpassed analyst estimates for the next quarter [1] - The market reaction to NVIDIA's report was unexpected, with a sell-off occurring despite the positive results [1] 分组2 - Michael Fitzsimmons, a retired electronics engineer, suggests that investors should build a diversified portfolio with a focus on a high-quality low-cost S&P 500 fund [1] - For those willing to accept short-term risks, an overweight position in the technology sector is recommended, as it is believed to be in the early stages of a long-term bull market [1] - Fitzsimmons also advises considering investments in large oil and gas companies for strong dividend income and growth [1] - His portfolio management approach emphasizes a top-down capital allocation strategy tailored to individual investor circumstances, including age, risk tolerance, and financial goals [1]
Gold price slightly up, silver higher ahead of U.S. PPI
KITCO· 2026-02-27 13:09
Group 1 - Jim Wyckoff has over 25 years of experience in stock, financial, and commodity markets, including roles as a financial journalist and reporter on commodity futures trading floors in Chicago and New York [1] - He has covered every futures market traded in the U.S. at various times throughout his career [1] - Jim is the owner of "Jim Wyckoff on the Markets," which provides analytical, educational, and trading advisory services [2] Group 2 - He has worked as a technical analyst for Dow Jones Newswires and as a senior market analyst with TraderPlanet.com [2] - Jim is also a consultant for the "Pro Farmer" agricultural advisory service and was the head equities analyst at CapitalistEdge.com [2] - He holds a degree in journalism and economics from Iowa State University [2]
Netflix drops its WBD bid, Block layoffs, Anthropic's DOD deadline and more in Morning Squawk
CNBC· 2026-02-27 13:08
Group 1: Paramount Skydance and Warner Bros. Discovery - Paramount Skydance is making a hostile takeover bid for Warner Bros. Discovery valued at $108.4 billion, which has led Netflix to withdraw from its deal to acquire some of WBD's assets after WBD's board deemed Paramount's offer superior [2][6] - Paramount's new all-cash bid is set at $31 per share, surpassing Netflix's current agreement with WBD, prompting Netflix to state that matching the offer is no longer financially attractive [6] Group 2: Employment Changes in Tech - Block, the fintech company, announced layoffs of over 4,000 employees, approximately half of its workforce, to position itself for long-term growth, resulting in a 20% surge in its shares during extended trading [3][4] - eBay also announced a reduction of about 800 roles, or 6% of its staff, as part of its investments in AI, indicating a trend of staffing changes across the tech industry [4] Group 3: Women's Wealth Growth - Women's cumulative investible assets in the U.S. are expected to nearly double from 2023 to 2030, with a significant transfer of over $100 trillion in wealth anticipated through 2048, marking a substantial shift in wealth control [10]
Golden Entertainment (GDEN) Reports Q4 Loss, Lags Revenue Estimates
ZACKS· 2026-02-27 13:06
Golden Entertainment (GDEN) came out with a quarterly loss of $0.01 per share versus the Zacks Consensus Estimate of $0.11. This compares to earnings of $0.1 per share a year ago. These figures are adjusted for non-recurring items.This quarterly report represents an earnings surprise of -109.09%. A quarter ago, it was expected that this gaming services provider would post a loss of $0.08 per share when it actually produced a loss of $0.18, delivering a surprise of -125%.Over the last four quarters, the comp ...
Amadeus IT Group SA Unsponsored ADR (AMADY) Q4 Earnings and Revenues Beat Estimates
ZACKS· 2026-02-27 13:06
Amadeus IT Group SA Unsponsored ADR (AMADY) came out with quarterly earnings of $0.84 per share, beating the Zacks Consensus Estimate of $0.76 per share. This compares to earnings of $0.76 per share a year ago. These figures are adjusted for non-recurring items.This quarterly report represents an earnings surprise of +11.26%. A quarter ago, it was expected that this company would post earnings of $0.94 per share when it actually produced earnings of $0.98, delivering a surprise of +4.26%.Over the last four ...
Flutter Entertainment Posts Downbeat Q4 Results, Joins Zscaler, Elastic And Other Big Stocks Moving Lower In Friday's Pre-Market Session - Apartment Inv & Mgmt (NYSE:AIV), Ambarella (NASDAQ:AMBA)
Benzinga· 2026-02-27 13:06
U.S. stock futures were lower this morning, with the Dow futures falling around 250 points on Friday.Shares of Flutter Entertainment PLC (NYSE:FLUT) fell sharply in pre-market trading after the company reported worse-than-expected fourth-quarter financial results and issued weak FY26 revenue guidance.Flutter reported fourth-quarter revenue of $4.74 billion, up 25% year-over-year. The revenue missed a Street consensus estimate of $4.97 billion, according to data from Benzinga Pro. The company reported quarte ...
Come Meet NioBay Metals at PDAC 2026 in Toronto
TMX Newsfile· 2026-02-27 13:06
Montreal, Quebec--(Newsfile Corp. - February 27, 2026) - NioBay Metals Inc. (TSXV: NBY) ("NioBay") will participate in the Prospectors & Developers Association of Canada's (PDAC) International Convention, taking place March 1-4, 2026 at the Metro Toronto Convention Centre (MTCC) in Toronto. Shareholders, investors, and industry partners are invited to visit the Company at Booth #3015.Chief Executive Officer Jean-Sébastien David will be present at the booth throughout the convention and welcomes the opportu ...
Bragg Gaming Group Facilitates Executive Block Trade
Financialpost· 2026-02-27 13:05
Article contentTORONTO — Bragg Gaming Group ( NASDAQ: BRAG, TSX: BRAG) (“Bragg” or the “Company”), a leading iGaming content and technology provider, today announced that its Board of Directors approved a limited waiver of the company’s scheduled blackout period, in order to permit its chief executive officer, Matevž Mazij, to conduct a block sale of 1,039,000 common shares of the Company to a single purchaser in a private transaction (the “Sale”). The Board granted the waiver in response to a request from ...