Core Viewpoint - A video blogger accused Colgate's social media account of unauthorized use of their original video for commercial marketing without consent, raising concerns about intellectual property rights and the use of AI in content manipulation [1][5]. Group 1: Incident Overview - The video blogger "Even3不知" reported that Colgate's account used their original video, which was set to be released on February 28, 2025, for promotional purposes without their knowledge [1]. - The original content discussed a new technology for dental care, while the altered version misrepresented the technology as a Colgate innovation [4]. - The blogger emphasized that their content was unrelated to the claims made in the infringing video, which suggested that Colgate's toothpaste could repair dental gaps [5]. Group 2: Response and Legal Context - The blogger has taken steps to document the infringement and has requested Colgate to cease the unauthorized use of their content, indicating potential legal action if a satisfactory response is not received [5]. - Colgate's customer service acknowledged the issue and stated that a specialist was addressing the matter [8]. - Previous legal cases involving unauthorized use of AI-generated content highlight the potential for significant repercussions for companies that fail to verify the legitimacy of their marketing materials [8][9]. Group 3: Public Reaction and Implications - The incident has sparked varied reactions from the public, with some accusing Colgate of "video theft" and "fraud," while others speculated on the practices of Colgate's advertising team [5]. - The ongoing situation raises questions about the responsibilities of companies in verifying the content they use for marketing, especially in the context of AI technology [9].

（来源：化妆品观察 品观） 12月23日，为规范牙膏备案管理工作，国家药监局正式发布关于牙膏备案管理有关事项的公告（2025年第124号），明确首批上市销售日期在2021年1月1 日之后，已完成简化备案的牙膏产品，在满足特定条件的前提下，可免于提交口腔黏膜刺激试验报告。 科学界定边界， 筑牢安全根基 全面理解公告内涵，首先需厘清"豁免"的核心逻辑与适用条件——此次新政绝非简单取消安全检测要求，而是基于风险分级的监管优化，是建立在更精准 风险管控基础上的精细化管理创新。口腔黏膜刺激试验作为牙膏备案阶段的关键安全检测项目，核心作用是模拟产品日常使用场景，评估刺激、过敏等潜 在风险，其安全防控目标始终未变。 企业申请免于提交口腔黏膜试验报告，必须同时满足两大硬性前提：其一，产品需完成科学充分的安全风险评估，评估结果必须明确证明不会对口腔黏膜 健康产生危害，这是守住产品安全的第一道防线；其二，企业需提供完整详实的产品安全使用历史证明资料，包括生产销售情况、质量安全事件记录、不 良反应监测情况等。这些长期积累的真实世界实践数据，将成为替代动物试验报告的重要依据，从市场应用层面充分论证产品安全性。 公告的正式发布，进一步 ...

Core Viewpoint - Shanghai Kaijie E-commerce Co., Ltd. (Kaijie E-commerce) has submitted its prospectus for an IPO on the Hong Kong Stock Exchange, marking its second attempt at going public after withdrawing its A-share application in 2021 [1][4]. Company Overview - Established in 2010, Kaijie E-commerce is a comprehensive e-commerce service provider, offering B2B and B2C sales as well as data-driven creative marketing services [1]. - According to data from ZhiShi Consulting, Kaijie E-commerce is the fifth largest digital retail solution provider in China and the largest O2O digital retail solution provider based on GMV projections for 2024 [1]. Previous IPO Attempts - Kaijie E-commerce first entered the New Third Board in May 2016 but voluntarily delisted in July 2019 to streamline operations and reduce costs [2]. - After two years, the company attempted to list on the A-share market in June 2021 but withdrew its application in December 2021 before completing the inquiry process [3]. Reasons for Switching to Hong Kong - The company cited low liquidity of shares on the New Third Board as a barrier to public financing and business growth [4]. - Listing on the Hong Kong Stock Exchange is seen as a way to enhance financing capabilities, expand the shareholder base, and improve international market recognition [4]. Financial Performance - Kaijie E-commerce has experienced a decline in both revenue and net profit for three consecutive years from 2022 to 2024, with revenues of 1.829 billion, 1.723 billion, and 1.699 billion yuan respectively, and net profits of 86.47 million, 67.59 million, and 60.43 million yuan [5][6]. - The company's gross profit margin has also decreased from 24% in 2022 to 21.8% in 2024 [8]. Client Base Changes - Previously, Colgate was one of Kaijie E-commerce's top five clients, contributing sales of 38.57 million, 42.04 million, and 59.10 million yuan from 2018 to 2020, but is no longer among the top clients [9][8]. Industry Context - The beauty e-commerce service industry is facing significant challenges, with many operators, including Kaijie E-commerce, reporting declining revenues and profits [15]. - Among six listed beauty e-commerce operators, only Ruoyuchen has shown revenue growth in 2024 and the first quarter of 2025, while others have experienced varying degrees of decline [16][17].