Core Insights - The research reveals the different responses of the human body to single and long-term exercise, identifying a key "exercise-mimicking molecule" called betaine [1][2] - The study establishes that exercise can delay aging by regulating rhythm factors, promoting vascular regeneration, and suppressing systemic inflammation [1] - A significant breakthrough is the identification of the kidneys as a core organ responding to the health benefits of exercise, with long-term exercise significantly increasing betaine levels in the kidneys [2] Group 1 - The research team conducted a study involving 13 healthy male volunteers and cross-species research between mice and humans to detail the body's response to exercise [1] - Single intense exercise is characterized as a "survival stress test," leading to metabolic storms and oxidative damage, while long-term regular exercise rebalances multiple body systems [1] - Long-term exercise improves metabolism, rejuvenates the immune system, reduces inflammation, enhances antioxidant capacity, and optimizes gut microbiota [1] Group 2 - Betaine, derived from choline in the kidneys, is synthesized through a key enzyme activated post-exercise, which is crucial for its health benefits [2] - In cellular studies, betaine treatment significantly improves the aging state of various human aging cells, while in animal studies, it extends the healthy lifespan of elderly mice and improves various health metrics [2] - Betaine acts on a natural immune kinase called TBK1, inhibiting its activity and blocking pro-inflammatory signaling pathways, thereby reducing inflammation levels in tissues [2]

Core Insights - A new tool based on brain scan images has been developed to estimate the aging speed of individuals, which can predict risks of dementia, cardiovascular diseases, lung diseases, and early death [1][2] - The tool, named DunedinPACNI, was trained using MRI images from 860 participants at age 45 and validated with data from 42,583 participants in the UK Biobank and 1,737 brain images from the Alzheimer's Disease Neuroimaging Initiative [1][2] Group 1 - The DunedinPACNI model indicates that individuals who age faster perform worse on cognitive tests and experience quicker hippocampal atrophy, leading to a higher likelihood of developing dementia in the coming years [2] - Accelerated agers not only show significant declines in brain function but also have poorer overall health, with a significantly increased probability of common age-related diseases such as heart disease, stroke, and chronic lung disease [2] - The risk of being diagnosed with chronic diseases within a few years is 18% higher for accelerated agers, and their mortality risk is approximately 40% higher [2] Group 2 - The research team acknowledges that the tool is still some distance from clinical application and requires further validation across different age groups, ethnicities, and equipment environments for stability and accuracy [2]

撰文丨王聪 编辑丨王多鱼 排版丨水成文 近年来， CAR-T 细胞疗法 在血液类癌症、自身免疫疾病中展现了强大的治疗效果。相比传统的 体外 CAR-T （ ex vivo CAR-T ） ，基于 mRNA 的 体内 CAR-T （ in vivo CAR-T） 具有多种 显著 优势，包括生产流程更简化、瞬时表达等。 然而，当 前的 的 in vivo CAR-T 依赖于使用经过抗体修饰的脂质纳米颗粒 （LNP） 进行体内递送，这为生产制造带来了新的挑战。 2 025 年 7 月 1 日，北京大学药学院 苗蕾 研究员、 北京大学国际癌症研究院/北京大学肿瘤医院 邓觅 研究员、上海环码生物 杨赟 博士及迈威生物的研究人员 合作，在 Cell 子刊 Cell Reports Medicine 上发表了题为： Cardiolipin-mimic lipid nanoparticles without antibody modification delivered senolytic in vivo CAR-T therapy for inflamm-aging 的研究论文。 近年来， CAR-T 细胞疗法 彻底改变了 ...

撰文丨王聪 编辑丨王多鱼 排版丨水成文 衰老的特征之一是整个生物体中干细胞的衰老、功能下降以及数量下降。全身性慢性低度炎症 （炎性衰老） 涉及循环促炎细胞因子和趋化因子水平升高，并导致 干细胞衰老。 异时性联体共生 （Heterochronic Parabiosis， 通过外科手术将两只不同年龄的动物的循环系统连接起来，使其共享血液和体液 ） 研究表明，来 自老年个体循环中的系统性因素可诱导过早衰老，而年轻个体的循环则能使老年组织恢复活力。然而，全身性炎症对肌肉干细胞 （MuSC） 衰老的具体影响，目 前仍不清楚。 威斯康星大学麦迪逊分校、 罗切斯特大学医学中心的研究人员在 Nature 子刊 Nature Aging 上发表了题为 ： Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis 的研究论文。 该研究表明， 全身性炎症 通过诱导 表观遗传侵蚀 ，促进 肌肉 干细胞 发生 铁死亡 ，而长期抑制全身性炎症，能够 有效预防铁死亡，保持肌肉干细胞数量，并 促进肌肉再生和功能恢复。 衰老 ...

日前，谷歌旗下抗衰老公司 Calico Life Sciences 宣布 与 迈威生物 （Mabwell） 达成一项总价 近6 亿美 元 的生物制药交易，以获取针对 白介素-11 （IL-11） 的研究性疗法权益，其中包括一种用于治疗年龄相 关疾病的临床阶段单克隆抗体 9MW3811 。 撰文丨王聪 编辑丨王多鱼 排版丨水成文 据悉，迈威生物已在临床前研究中探索了 9MW3811 在年龄相关疾病领域的治疗潜力，已在中国及澳大利 亚完成了 1 期临床研究 ，显示出对 特发性肺纤维化的治疗潜力 ，并在美国获批开展 1 期临床研究。 根据许可协议，迈威生物独家许可 Calico 在除大中华区以外所有区域内独家开发、生产和商业化 9MW3811 的权利。 Calico 将向迈威生物支付一次性不可退还的首付款 2500 万美元 ，此外，迈威生物 还可额外获得合计最高达 5.71 亿美元 的近端、开发、注册及商业化里程碑付款 ，以及按许可产品净销售 额计算的阶梯式特许权使用费。 Calico 由谷歌母公司 Alphabet 和行业巨 头 Arthur Levinson 博士共同创立，该公司旨在进一步了解衰老 的生物学原理 ...

撰文丨王聪 编辑丨王多鱼 排版丨水成文 骨关节炎 （OA） 是一种累及整个关节的疾病，包括病理变化，如软骨损伤、软骨下骨重塑和滑膜炎症。 关节周围的 肌肉萎缩 是骨关节炎患者常见的身体表现，是骨关节炎发病的一个标志，并且与膝关节症状和 关节病理恶化有很强的相关性。然而，骨关节炎相关肌肉萎缩的病理特征和分子机制在很大程度上仍不清 楚，这极大地限制了临床治疗的效果。 细胞衰老 是一种永久性的细胞周期停滞状态，在不同的生理和病理过程中发挥着重要作用。近期来自高通 量测序的数据在衰老骨骼肌中识别出了细胞衰老的典型特征。 清除衰老细胞已被证明能促进肌肉再生，并 抑制多种肌肉疾病中的肌肉萎缩。相反，在某些情况下，衰老细胞也可能对肌肉再生起到积极的调节作 用，例如，在蝾螈中，衰老细胞可以通过促进肌肉的去分化来增强肢体再生 。然而，目前尚不清楚 衰老细 胞 是否与 骨关节炎相关肌肉萎缩 有关。 2025 年 6 月 27 日，陆军军医大学/陆军特色医学中心 倪振洪 、 周思儒 、 陈林 、 连继勤 等人在 Nature Aging 期刊发表了题为： Senescent macrophages induce ferroptos ...

迈威生物 20250627 Q&A 迈威生物此次与齐鲁制药和 Calico 的 BD 合作，对公司整体战略和现金流有 何重要意义？ 此次与齐鲁制药和 Calico 的 BD 合作对迈威生物具有重要的战略意义。首先， 与齐鲁制药就长效升白药（05）达成合作，回流了 5 亿元现金，并可获得最高 两位数的销售提成，这笔资金将有力补充公司的现金流。其次，此举符合迈威 生物聚焦创新的战略转型，公司希望将资源更集中于全球新创新药的推进，包 括上市阶段以及寻求更多 BD 交易机会。对于长效升白药，尽管迈威生物在地 舒单抗（友松）的销售上表现出色，2023 年放量 1.39 亿元，同比增长 230% 以上，国产院内市占率排名第一，院外市场占有率也排名第一，但考虑到长效 升白药需要建立 500 甚至 1,000 人以上的强大销售团队，将该产品授权给在肿 瘤领域销售能力强大的齐鲁制药，是一个非常适合的策略。此外，与 Calico 就 白介 11（IU11）达成海外授权，获得了 2,500 万美元的预付款，这不仅补充 白介 11（IU11）未来可能拓展的适应症包括肿瘤和纤维化相关疾病， 在肿瘤领域有望提升免疫疗法疗效，在纤维化方面 ...

Industry Overview - The Chinese medical beauty market is projected to reach 312 billion yuan in 2024, representing a growth of 14.8% compared to 2023 [1] - The demand for medical beauty in China is still on the rise, with a notable increase in male participation in the sector [3][5] Market Trends - The global medical beauty industry shows that the United States leads in the number of procedures, followed by Brazil, Japan, China, and India [3] - Common procedures for women include liposuction, breast augmentation, eyelid surgery, abdominal contouring, and breast lift, while men primarily undergo eyelid surgery and gynecomastia correction [3] Consumer Behavior - Many individuals pursue medical beauty not solely for aesthetics but also for self-confidence enhancement [6] - There is a growing trend among younger generations to invest time in beauty routines, raising questions about the motivations behind such practices [6][12] Psychological Aspects - The aging process is a natural phenomenon, and while medical beauty can delay visible signs of aging, it cannot prevent them [7] - The perception of beauty and self-worth is increasingly influenced by societal standards and media portrayals, leading to a complex relationship between self-esteem and appearance [6][12] Aesthetic Diversity - There has been a shift from a homogenized beauty standard, often referred to as "internet celebrity face," to a more diverse representation of beauty in media and entertainment [9] - The industry is moving towards emphasizing individual features rather than conforming to a singular aesthetic [9] Private Aesthetic Procedures - Private aesthetic procedures, particularly in the genital area, are gaining attention, with a focus on addressing both medical and cosmetic needs [14][15] - There is a need for better education and destigmatization surrounding these procedures, as many women may have legitimate health concerns that require attention [15][16]

新型化合物可显著延长线虫寿命 智通财经6月27日电， 日本研究人员最新开发出一种名为proAX的化合物，能激活细胞中线粒体的呼吸 作用，提高细胞的能量代谢水平和抗压能力。实验证明，它能够显著延长实验用线虫的寿命。研究论文 已发表在新一期《美国化学学会杂志》上。细胞线粒体负责合成三磷酸腺苷，这是生命活动所需能量的 直接来源。随着机体老化，线粒体功能逐渐减弱，三磷酸腺苷产量减少，导致能量代谢下降并引发多种 生理机能退化。目前，能有效增强线粒体呼吸、提升三磷酸腺苷水平的药物在全球范围内非常稀少。公 报说，这一成果为改善衰老相关的能量代谢下降提供了新的解决思路。后续，研究团队将进一步在小鼠 等哺乳动物体内评估proAX的效果。 (新华社) ...

Core Insights - A Chinese research team has revealed that the kidneys are a key organ in the effects of exercise, with the metabolite betaine acting as a core molecular messenger to delay aging by targeting and inhibiting the natural immune kinase TBK1, thereby alleviating inflammation and multi-organ aging processes [1][2] Group 1: Research Findings - The research, conducted over six years, provides a systematic analysis of the molecular and cellular responses to both acute single exercise and long-term regular exercise [1] - The findings offer cross-scale and cross-species scientific evidence for the positive effects of exercise on health, supporting active health interventions for aging [1] Group 2: Implications for Health and Aging - The study introduces a new paradigm of "endogenous metabolite-mediated exercise benefits," transforming complex physiological effects into quantifiable and operable chemical language [1] - This research lays the groundwork for developing "exercise-mimicking drugs" as a new strategy for systemic aging intervention [1][2]