When you got eyes on this new research, what struck you. >> Yeah, so for a long time, Morgan, we've known that there is a genetic risk that you can test for, a gene called the APO E4 gene. I'll just refer to it as the APO gene.It gives you a higher risk of Alzheimer's. And more and more people are getting that checked out. What we always have tried to figure out though is does a genetic risk automatically translate to a clinical risk.Can you have the gene and can you overcome the clinical possibility of dem ...

Health & Wellness - Simple steps to stay mentally and physically active improved thinking and helped keep Alzheimer's disease at bay for older Americans at high-risk of developing dementia [1] - The positive effects of these steps were observed relatively quickly [1]

FDA & HRT Treatment Overview - FDA is clarifying the use of hormone replacement therapy (HRT) for perimenopause and menopause, suggesting previous risk assessments may be overstated [1] - The central argument revolves around whether the benefits of HRT outweigh the risks, particularly concerning stroke, blood clots, dementia, and breast cancer [3][6][8] Risk Assessment & Black Box Warning - Current medication labels include a black box warning about increased risks of heart disease, heart attack, strokes, and breast cancer [2][5] - The FDA is considering removing the black box warning due to arguments that the benefits of HRT outweigh the risks [5][6] - A 2002 women's health initiative study, with an average participant age of 63, is being re-evaluated, as HRT is often prescribed to women in their late 40s and 50s [6] - The perceived risk of breast cancer from HRT is considered by some to be overblown [7] - Baseline risk of developing breast cancer is around 13% for women in the United States [3][4] Benefits of HRT - Potential benefits of HRT include reduced risk of dementia and Alzheimer's, prevention of bone loss, and alleviation of menopause symptoms like hot flashes, poor sleep, and brain fog [8] - Estrogen, a key component of HRT, aids neurotransmitter function, potentially lowering the likelihood of dementia and Alzheimer's [9][10]

Hearing Loss Impact - Untreated hearing loss can lead to significant listening effort, causing exhaustion and potentially shrinking a person's world [4][5][6] - Hearing loss, particularly high-frequency hearing loss, is often unrecognized, affecting one in three people aged 65-74 and half of those over 75 [7][8] - Untreated hearing loss is associated with increased dementia risk, with a study attributing 32% of dementia cases to it [9] - Brain atrophy, specifically shrinkage in the auditory cortex and areas related to memory and speech, is observed in MRI scans of individuals with untreated hearing loss [10] - Individuals with hearing loss are 57% more likely to experience loneliness, which can negatively impact the immune system, increase inflammation, and shorten life expectancy [10] Hearing Loss Treatment - Hearing aid use can cut the risk of cognitive impairment in half for people with high dementia risk scores [11] - Early intervention and advocacy are crucial, as many individuals with hearing loss may not recognize the problem themselves [14][15]