21世纪经济报道记者 韩利明 12月12日盘前，药明巨诺（02126.HK）发布公告，宣布一系列核心管理层及董事会架构调整。其中， 田丰将于2025年12月29日起正式出任公司行政总裁及执行董事；刘诚博士则自2025年12月12日起出任董 事会主席一职。 同时，2024年7月上任的原首席执行官刘敏，因个人事业发展规划，于2025年12月12日起辞任，同时退 出董事会提名委员会及业务发展与策略委员会。药明巨诺董事会在2025年9月批准的、拟授予刘敏的超 420万份购股权，亦同步宣告取消。 为保障管理过渡期间的运营稳定，药明巨诺表示，在田丰正式履职前，现有管理层将暂代行政总裁职 责，确保公司日常运营平稳有序。授权代表方面亦同步调整：12月12日起，由刘诚博士与公司秘书吴嘉 雯共同担任；自12月29日起，由田丰接替刘诚博士，与吴嘉雯共同履行联交所规定的授权代表职责。 职业历程显示，其曾担任Chiron Corporation（现被诺华收购）抗体药物研发首席科学家；于2020年6月 加入药明巨诺担任非执行董事，目前同时担任优瑞科生物技术公司创始人、行政总裁兼董事，纳斯达克 上市公司Estrella Immunopha ...

Summary of Gilead Sciences FY Conference Call (December 03, 2025) Company Overview - **Company**: Gilead Sciences (NasdaqGS:GILD) - **Focus Areas**: Virology, Oncology, Inflammation Key Points R&D and Product Development - **Transition and Performance**: The transition to Gilead has been positive, with successful data and multiple product launches throughout the year [1][2] - **Nodule Data**: Clinical studies (Purpose 1 and Purpose 2) show 96% of participants want to continue therapy, indicating no significant clinical issues with nodules formed during treatment [2][3] - **Intramuscular Injection**: The move to intramuscular injections allows for longer duration therapies, including a once-a-year option for HIV prevention [3][4] - **Patient Compliance**: The injectable format improves compliance compared to daily oral medications, as patients receive protection for six months with a single shot [7][9] - **GS-3242 Development**: GS-3242 is prioritized as a longer-acting integrase inhibitor, with potential for future treatment intervals [12][15] - **Clinical Holds**: A combination therapy involving a long-acting capsid was placed on clinical hold due to safety concerns related to CD4 positive T cell counts [16][18] Market Positioning and Strategy - **Biktarvy**: Remains the standard of care for newly diagnosed patients, with no current plans to replace it with GS-3242 [12][31] - **BIC-Len**: Positioned for switch settings, targeting patients who want to transition from complex regimens to simpler two-drug therapies [34] - **Long-acting Options**: Gilead is exploring longer duration therapies, including a once-every-six-month injectable regimen [33] Pipeline Developments - **Oral GLP-1**: Currently in phase one, not a core strategy but could be developed further depending on trial results [35][36] - **Oral Alpha-4 Beta-7**: Part of Gilead's inflammation strategy, with ongoing phase two trials in inflammatory bowel disease [39][40] - **Cell Therapy**: Gilead is advancing its CAR-T therapies, including a next-generation CD19/CD20 CAR-T aimed at improving efficacy and safety [47][48] Future Directions - **In Vivo CAR-T**: Gilead is investing in in vivo CAR-T technologies, which stimulate the body to produce its own CAR-T cells, although this is still in early stages [61][64] - **Clinical Trials**: Upcoming data from the Imagine-1 study on myeloma therapy will provide insights into efficacy and safety [51][52] Safety and Efficacy - **Resistance Formation**: Current data shows low resistance formation with BIC-Len and GS-3242, with ongoing monitoring as patient populations expand [24][26] - **ICANS and Neurotoxicity**: Limited incidence of ICANS reported, with ongoing assessments of safety profiles across trials [55][56] Additional Insights - **Market Dynamics**: Gilead is aware of competitive pressures and is focused on providing diverse treatment options to meet patient needs [34][33] - **Partnership Opportunities**: Potential for partnerships in non-core areas like oral GLP-1 and oral alpha-4 beta-7, depending on trial outcomes [38][44] This summary encapsulates the key discussions and strategic directions highlighted during the Gilead Sciences FY conference call, focusing on R&D advancements, market positioning, and future growth opportunities.