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别急着让诺奖“治病”:调节性T细胞离药还远
Hu Xiu· 2025-10-09 12:35
对此,该泼的冷水还是要泼的,到目前为止,基于调节性T细胞产生的上市药品数量是:0。 本文来自微信公众号:一个生物狗的科普小园,作者:Y博的科普园,题图来自:AI生成 2025年诺贝尔生理学与医学奖给了调节性T细胞的发现。大概是由于该奖是在与疾病过度相关的免疫学 领域,而且也在包括肿瘤、自身免疫疾病等方向的研究中扮演关键角色,不少人对该奖成果的应用充满 期待。 不过,网络上的热度往往跑得比科学还快。一些文章宣称"未来XX病有望被治愈",甚至有人蹭热点声 称某维生素影响调节性T细胞,能起到XX作用。 它们都不是基于调节性T细胞的研究。 一个都没有。 尽管有些靶向或利用调节性T细胞的药物、疗法在临床试验阶段,预计的上市时间也会是好几年后—— 能否成功也有巨大的不确定性。 参考获奖者之一,坂口志文获奖消息公布后,在日本大阪大学新闻发布会上的小插曲。日本首相在发布 会中间打电话祝贺,其中问到研究什么时候能治好癌症,坂口志文的回答是可能20年后,自己那会儿还 在不在都不确定。 坂口志文与另一位获奖者Ransdell都创建了将调节性T细胞用于疾病治疗的生物技术公司。但是这些公 司与调节性T细胞相关的产品都处于早期研发阶段。 ...
协和专家:什么是好的免疫力?
Hu Xiu· 2025-08-29 08:31
Core Viewpoint - The discussion emphasizes the importance of understanding autoimmune diseases, particularly lupus and antiphospholipid syndrome, and highlights advancements in treatment options, including cell therapy, which can significantly improve patients' quality of life and reproductive outcomes [1][30][36]. Group 1: Autoimmune Diseases Overview - There are over a hundred types of autoimmune diseases, affecting a significant population, yet awareness remains low [3]. - Common autoimmune diseases include lupus, antiphospholipid syndrome, and arthritis, with a notable prevalence among women [4][14]. - Patients often form support groups to share experiences and encourage each other, especially regarding expensive treatments [4][18]. Group 2: Patient Experience and Treatment - The role of physicians extends beyond treatment; they provide emotional support and guidance to help patients navigate their conditions [7][10]. - Many patients initially experience anxiety and uncertainty about their conditions, but with ongoing care, they often become more at ease [7][12]. - The importance of accurate diagnosis and treatment plans is emphasized, particularly in managing conditions like antiphospholipid syndrome, which can significantly impact pregnancy outcomes [16][23]. Group 3: Advances in Treatment - Cell therapy shows promise in treating autoimmune diseases by specifically targeting B cells, potentially leading to long-term remission [30][33]. - New biological agents, particularly monoclonal antibodies, are emerging as effective treatments for lupus and other autoimmune conditions [35]. - The success rate for lupus patients achieving healthy pregnancies has improved significantly, with over 80% of children born to lupus patients being healthy [28][36]. Group 4: Misconceptions and Patient Education - There is a tendency for patients to self-diagnose with conditions like antiphospholipid syndrome due to its treatable nature, which can lead to over-treatment and misinformation [21][22]. - The need for standardized antibody testing across different regions is highlighted to ensure accurate diagnosis and treatment [24]. - Patients are encouraged to maintain a balanced lifestyle and not to overly focus on their autoimmune conditions, as this can lead to unnecessary anxiety [50][53].