Core Viewpoint - The article emphasizes the importance of maintaining a balanced immune system, especially during the winter months when external factors like cold weather and viral infections can challenge immune function [1][3]. Group 1: Immune System Challenges - The immune system faces dual challenges in winter due to increased metabolic consumption from cold weather and the enhanced survival and transmission of viruses as temperatures rise [3][5]. - Experts suggest that scientific interventions can help activate immune potential to manage health risks and maintain immune stability throughout the year [5]. Group 2: Factors Affecting Immunity - Poor hydration can lead to decreased immune function, as adequate water intake keeps respiratory mucous membranes moist, preventing rapid reproduction of pathogens [7]. - Unhealthy eating habits, such as overeating or undereating, can disrupt gut immunity and lead to chronic inflammation; insufficient protein intake affects immune cell repair and proliferation [8]. - Lack of physical activity can lead to a rapid decline in immune function, with significant muscle loss correlating to increased susceptibility to infections [9][10]. - Poor sleep quality disrupts endocrine balance, which can lower immune function, while chronic fatigue and insomnia can exacerbate this issue [11]. - Negative emotions like stress and anxiety can alter hormone levels and lead to chronic inflammation, interfering with normal immune system function [12]. Group 3: 28-Day Immunity Enhancement Plan - The plan focuses on four core dimensions: nutrition, exercise, sleep, and mental health, aiming to cultivate "immunity-friendly habits" over 28 days [13]. - Nutrition recommendations include sufficient intake of high-quality protein (0.8-1g per kg of body weight daily) and a colorful diet rich in fruits and vegetables to boost immune activation [14][16]. - Regular moderate-intensity exercise (150 minutes per week) is advised to enhance blood circulation and immune cell distribution [18]. - Sleep hygiene practices suggest going to bed before 11 PM and creating a conducive sleep environment to support immune repair [20][22]. - Mental health strategies include managing stress through mindfulness and social interactions to provide emotional support for the immune system [25][26].

Core Insights - The "2025 Annual Top Ten Nutrition Buzzwords" were released, highlighting key areas of focus in nutrition such as "weight management," "anti-aging," "gut health," and "sleep health" [2] Group 1: Nutrition Buzzwords - The top ten nutrition buzzwords for 2025 include "weight management," "anti-aging," "gut health," "sleep health," "microplastics," "pre-prepared meals," "healthy aging," "smart canteens," "anti-inflammatory diet," and "immunity" [2] - These keywords reflect growing public interest in health and nutrition, particularly among younger demographics [2] Group 2: Pre-prepared Meals - Concerns regarding pre-prepared meals primarily revolve around "poor ingredient quality," "use of additives," "unsatisfactory taste," and "low nutritional value" [3] - The nutritional value of pre-prepared meals is influenced by ingredient quality, cooking methods, cold chain storage, and seasoning techniques [3] - Future trends may include the development of "low-salt," "light-oil," and "nutrient-enhanced" pre-prepared meal products, driven by consumer demand for improved quality and regulation [3] Group 3: Immunity - The understanding of immunity is shifting from merely enhancing it to achieving a state of "immune homeostasis" [3][4] - A balanced diet is crucial for maintaining immune homeostasis, with quality proteins, vitamins A and D, zinc, and selenium playing significant roles [4][5] - Lifestyle factors such as sleep, exercise, and stress management are also essential for stabilizing immunity [5] Group 4: Weight Management - Scientific weight management emphasizes maintaining a healthy weight and body composition over time, focusing on monitoring weight, balanced diet, regular exercise, and psychological well-being [6] - Key recommendations include monitoring BMI, waist circumference, and body fat percentage, along with a balanced intake of fruits and whole grains [6] Group 5: Gut Health - Gut health is increasingly linked to the "gut-brain axis," with dietary choices significantly impacting gut microbiota balance [7] - A diet rich in dietary fiber, polyphenols, and low in processed foods is recommended to support gut health [7][8] - Practical adjustments in lifestyle, such as cooking at home and managing stress, can help maintain gut health [8] Group 6: Sleep Health - The prevalence of insomnia among adults in China is high, particularly among younger populations [9] - Nutritional interventions for better sleep include foods rich in tryptophan, magnesium, and B vitamins, while avoiding caffeine and high-sugar foods [9] - Good sleep hygiene practices, including regular sleep schedules and stress management, are essential for sleep health [9] Group 7: Anti-inflammatory Diet - An anti-inflammatory diet targets chronic inflammation rather than acute inflammation, aiming to reduce health risks associated with chronic diseases [10][11] - Key features of an anti-inflammatory diet include a high intake of fresh plant-based foods, healthy fats, and antioxidants, while minimizing processed foods and sugars [11] - Incorporating spices and herbs can further enhance the anti-inflammatory effects of the diet [11]

Core Viewpoint - The article discusses the evolving understanding of "immunity" in the context of nutrition and health, emphasizing the shift from merely enhancing immunity to maintaining a balanced immune state, termed "immune homeostasis" [3][4][9]. Group 1: Immunity Understanding - The public's perception of immunity is changing, moving from a simplistic view based on susceptibility to colds to a more nuanced understanding of it as a system that requires long-term maintenance [3]. - A healthy immune system is characterized by a dynamic balance between being "too weak" and "overactive," highlighting the importance of nutritional interventions in supporting immune function [4]. Group 2: Nutritional Recommendations - The "2025 China Resident Nutrition Literacy Annual Report (Elderly)" identifies that elderly populations face challenges such as weakened immune function and declining muscle mass, necessitating improved nutritional literacy [6]. - Recommendations include integrating nutritional assessments into health records for the elderly and enhancing professional nutritional guidance in community and healthcare settings [6]. Group 3: Traditional and Modern Approaches - The use of polysaccharides from traditional Chinese herbs is highlighted as a promising method for immune regulation, linking Eastern wisdom with modern nutritional science [5][9]. - The article emphasizes the need for a continuous nutritional support plan that combines traditional health concepts with contemporary research to enhance immunity and maintain balance [6][9]. Group 4: AI in Health Management - The introduction of an AI assistant, "Lingzhi," aims to translate complex health knowledge into actionable daily practices, assisting users in understanding the relationship between immunity and daily health management [12]. - "Lingzhi" provides personalized recommendations based on individual circumstances, promoting the integration of immune health practices into everyday life [12].

Core Insights - The article discusses the groundbreaking research on "peripheral immune tolerance" by Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi, which has led to their joint award of the 2025 Nobel Prize in Physiology or Medicine [1][3][10] - Their findings reveal how the immune system avoids attacking its own tissues, highlighting the role of regulatory T cells in maintaining immune balance and preventing autoimmune diseases [3][9] Group 1: Research Breakthroughs - The research challenges the previous consensus that immune tolerance primarily relies on "central tolerance" in the thymus, introducing the concept of regulatory T cells as a crucial component in peripheral immune tolerance [5][7] - Brunkow and Ramsdell identified a mutation in the Foxp3 gene in a mouse model that leads to severe autoimmune diseases, establishing a link between this gene and the function of regulatory T cells [5][7] - Sakaguchi later connected these findings, demonstrating that Foxp3 is essential for the development and function of regulatory T cells, which are vital for preventing systemic autoimmune responses [7][9] Group 2: Clinical Implications - The research has significant implications for the treatment of autoimmune diseases and cancer, with therapies based on regulatory T cells being actively explored for conditions like type 1 diabetes and rheumatoid arthritis [9][10] - The work of these scientists has paved the way for advancements in organ transplantation, potentially leading to more successful procedures by understanding immune tolerance mechanisms [9][10]

Core Insights - AnaptysBio's investigational drug rosnilimab shows a best-in-disease profile for treating moderate-to-severe rheumatoid arthritis (RA), demonstrating JAK-like efficacy and durable responses [1][2][3] Efficacy and Clinical Outcomes - In a Phase 2b trial with 424 patients, rosnilimab achieved significant clinical improvements, including low disease activity (LDA) and remission on the Clinical Disease Activity Index (CDAI) [1][2][3] - By Week 12, 45% of patients achieved CDAI LDA, increasing to 69% by Week 14, indicating a strong response to treatment [3][4] - Rosnilimab demonstrated a rapid onset of ACR20 response, comparable to upadacitinib, with a substantial decrease in C-reactive protein (CRP) levels [2][3] Safety and Tolerability - Rosnilimab exhibited a favorable safety profile, with no treatment-related serious adverse events (SAEs) reported and a low incidence of injection site reactions [10][11] - Less than 2% of patients discontinued treatment due to adverse events, indicating good tolerability [10][11] Market Potential - The findings suggest rosnilimab could capture a significant share of the ~$20 billion U.S. RA market, with potential for extended dosing intervals [2][3] - The company aims to complete ongoing studies for rosnilimab in ulcerative colitis, with initial data expected in Q4 2025 [2][14] Mechanism of Action - Rosnilimab targets PD-1+ T cells, aiming to restore immune homeostasis and reduce inflammation associated with RA [19][21] - The drug demonstrated a ~90% reduction in PD-1 T cells and a ~50% reduction in PD-1+ T cells, indicating robust pharmacological activity [8][19] Future Developments - AnaptysBio plans to advance rosnilimab's clinical development and explore its application in other autoimmune diseases [21][22] - The company is committed to developing innovative treatments that address the long-term needs of patients with chronic inflammatory conditions [21][22]