半胱氨酸限制减肥

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《自然》重磅研究:不吃这一物,7天狂瘦三成!纽约医学精英破解"懒人减肥"革命性秘方
GLP1减重宝典· 2025-08-11 09:07
Core Viewpoint - The article discusses the significant role of cysteine in weight management and metabolic regulation, highlighting recent research that shows cysteine restriction can lead to substantial weight loss and metabolic reprogramming, offering new therapeutic strategies for obesity and related metabolic diseases [6][9]. Summary by Sections Essential Amino Acids and Cysteine - In 1937, William C. Rose established the nine essential amino acids (EAA) necessary for human health, with cysteine becoming essential for organisms with specific gene mutations [6]. - Cysteine is crucial for protein synthesis and is a key component in the antioxidant defense system, particularly in the synthesis of glutathione [7]. Cysteine Restriction and Weight Loss - A study published in Nature revealed that conditional cysteine restriction can lead to a weight loss of up to 30% within one week, surpassing the effects of other essential amino acid restrictions [7][9]. - This weight loss effect is reversible and not influenced by environmental temperature [9]. Mechanisms of Action - Cysteine deficiency activates integrated stress responses and oxidative stress responses, creating a positive feedback loop that enhances the expression of key metabolic regulators like GDF15 and FGF21 [9]. - The study found a significant reduction in tissue coenzyme A (CoA) levels, leading to impaired mitochondrial function and metabolic reprogramming characterized by increased anaerobic glycolysis and TCA cycle dysfunction [9]. Implications for Obesity Treatment - The findings suggest that cysteine metabolism plays a central role in energy balance, providing new insights for addressing the global obesity crisis and related metabolic diseases [9].