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《自然》:去除一种氨基酸,一周体重骤降三成?!科学家研究发现,彻底剔除半胱氨酸摄入,能让小鼠在短短七天内体重降低30%.
GLP1减重宝典· 2025-10-05 10:57
以下文章来源于肥胖世界ObesityWorld ,作者欢迎订阅 肥胖已成为全球性的公共卫生难题,我国成年人超重率高达35%,肥胖率也达到14.6%。传统的"少吃多动"方法收效甚微。近日,《自然·代 谢》杂志发布了一项突破性研究,发现半胱氨酸的缺乏能激活脂肪燃烧机制,使动物在一周内减重高达30%,并逆转炎症反应,为肥胖干预 带来了全新的方向。 1. 代谢重塑新机制: 半胱氨酸是谷胱甘肽(GSH)和辅酶A(CoA)合成的核心原料。当体内半胱氨酸不足时,GSH和CoA含量下降,进而激活整合应激反应 (ISR)和氧化应激反应(OSR),推动脂肪氧化加速。动物实验显示,缺乏半胱氨酸的小鼠在短短一周内体重下降25-30%,脂肪组织大幅 减少;而一旦恢复正常饮食,体重又会回升,说明该过程具有可逆性。 2. 脂肪"棕色化"与产热新路径: 肥胖世界ObesityWorld . 《肥胖世界》Obesity World - 同步传真肥胖及代谢国际新学术进展,为医学减重临床、教研人员搭建一座与国际接轨的桥梁,「每医健」旗下内容平台。 白色脂肪转化为具有产热功能的棕色脂肪时,UCP1蛋白表达增强。但研究发现,即使敲除了UCP1基因,减 ...
《自然》重磅研究:不吃这一物,7天狂瘦三成!纽约医学精英破解"懒人减肥"革命性秘方
GLP1减重宝典· 2025-08-11 09:07
Core Viewpoint - The article discusses the significant role of cysteine in weight management and metabolic regulation, highlighting recent research that shows cysteine restriction can lead to substantial weight loss and metabolic reprogramming, offering new therapeutic strategies for obesity and related metabolic diseases [6][9]. Summary by Sections Essential Amino Acids and Cysteine - In 1937, William C. Rose established the nine essential amino acids (EAA) necessary for human health, with cysteine becoming essential for organisms with specific gene mutations [6]. - Cysteine is crucial for protein synthesis and is a key component in the antioxidant defense system, particularly in the synthesis of glutathione [7]. Cysteine Restriction and Weight Loss - A study published in Nature revealed that conditional cysteine restriction can lead to a weight loss of up to 30% within one week, surpassing the effects of other essential amino acid restrictions [7][9]. - This weight loss effect is reversible and not influenced by environmental temperature [9]. Mechanisms of Action - Cysteine deficiency activates integrated stress responses and oxidative stress responses, creating a positive feedback loop that enhances the expression of key metabolic regulators like GDF15 and FGF21 [9]. - The study found a significant reduction in tissue coenzyme A (CoA) levels, leading to impaired mitochondrial function and metabolic reprogramming characterized by increased anaerobic glycolysis and TCA cycle dysfunction [9]. Implications for Obesity Treatment - The findings suggest that cysteine metabolism plays a central role in energy balance, providing new insights for addressing the global obesity crisis and related metabolic diseases [9].