Investment Rating - The report maintains a "Positive" investment rating for the autoimmune dual-antibody sector [1]. Core Insights - The dual-antibody technology platform in the autoimmune disease field shows significant potential, with real-world clinical data validating its effectiveness. The focus should be on target selection and preclinical optimization, which are critical for determining clinical efficacy [3]. - The TCE (T-cell engagers) field is recommended to focus on combinations of CD3 with CD19/BCMA targets, while also being cautious of infection and low immunoglobulin levels as potential risks [3]. - There is a growing market for autoimmune diseases, with the global treatment market expected to exceed $220 billion by 2035, driven by increasing patient numbers in conditions like rheumatoid arthritis and psoriasis [19][21]. Summary by Sections 1. Autoimmune Disease Market Overview - There are over 150 types of autoimmune diseases, categorized into organ-specific and systemic types, with a significant patient population globally [13][15]. - The market for autoimmune disease treatments is projected to grow from $40 billion in 2023 to $263 billion by 2032 in China, reflecting a compound annual growth rate (CAGR) of 23.3% [21][19]. 2. Rise of Bispecific and Multispecific Antibodies - Bispecific antibodies (BsAbs) are emerging as a future direction for antibody drugs, with a market size expected to reach $484.8 billion by 2034, growing at a CAGR of 44.2% [31]. - The report highlights the rapid growth in sales of approved bispecific antibody drugs, with 19 products currently on the market [31]. 3. TCE Clinical Potential in Autoimmune Diseases - TCE therapies have shown significant clinical effects in various autoimmune diseases, with products like Teclistamab demonstrating strong B-cell clearance capabilities [3][19]. - The report emphasizes the need for careful clinical pre-screening for immunogenicity in dual-antibody products targeting multiple inflammatory pathways [3]. 4. Company Recommendations - For unlisted companies, the report recommends focusing on Huasheng Zhiyuan, Yikesite, and Huao Tai Biological, all of which have products with BD potential [3]. - For listed companies, it suggests paying attention to Weili Zhibo, Kangnuo Ya, and Quanxin Biological, particularly regarding their pipeline products and clinical data [3].