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3亿睡眠“特困生”有救了?国内就诊率不足30% 两款新获批的失眠药能带来哪些改变?
Mei Ri Jing Ji Xin Wen· 2025-09-22 13:19
"睡不着"是当代成年人的烦恼之一。 头豹研究院报告数据显示,在国内,2016年至2020年失眠症成人患病人数从2.5亿增至2.7亿,预计2024 年达3亿,2030年将增至3.3亿。对应地,中国睡眠经济市场规模日益增长,2021年,中国失眠药物市场 规模为122.8亿元,预计2025年达151.2亿元,至2030年将达到211.9亿元。 公开资料显示,由于国内创新药企主要聚焦肿瘤、自身免疫等市场空间巨大的热门赛道,对失眠类创新 药研发较少,目前已进入临床阶段的DORA失眠创新药包括扬子江药业的YZJ-1139、东阳光(600673) 药的HEC-83518。 在新的药物获批前,莱博雷生和达利雷生仍是主要的新型失眠药物。吉林大学第一医院王赞教授告诉记 者,对于从未使用过相关药物的患者来说,这两种药物均能有效改善睡眠总时长、缩短睡眠潜伏期,并 减少睡眠中的觉醒时间。如果患者对日间功能的要求较高,欧洲相关临床指南建议优先选择半衰期更短 的达利雷生。 造成这种现象主要有两个原因:一方面,传统抗失眠药物主要为苯二氮类和非苯二氮类镇静催眠药,其 虽能缩短入睡时间,却存在"日间嗜睡、认知损伤、药物依赖"等副作用。另一方面, ...
先声药业:与瑞士Idorsia公司合作的抗失眠创新药达利雷生在中国获批
Cai Jing Wang· 2025-06-23 12:08
Group 1 - The core viewpoint of the news is that the innovative insomnia drug Daridorexant (brand name: Kewico®) developed by the company in collaboration with Idorsia has been officially approved for marketing in China, enhancing patient access and supporting long-term use [1][2] - Daridorexant targets the orexin pathway in the hypothalamus, which is crucial for wakefulness, contrasting with traditional insomnia medications that act on GABA receptors to induce sedation [1] - The drug has shown significant clinical trial results, including reduced time to sleep onset and decreased wake time after sleep, with no serious adverse reactions reported during treatment [1] Group 2 - Daridorexant is the only DORA (Dual Orexin Receptor Antagonist) insomnia medication approved by the European Medicines Agency that improves daytime functioning, and it has been approved in 11 countries including the US, UK, and Japan [2] - The company entered into an exclusive licensing agreement with Idorsia for the development and commercialization of Daridorexant in the Greater China region, recognizing its market potential [2] - A supplementary agreement was reached between Idorsia and the company, involving a one-time cash payment of $50 million and adjustments to sales milestone payments and royalty rates, aimed at facilitating the commercialization of Daridorexant [2]