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清华×北大合作发表Cell子刊论文:揭开口腔病毒与肥胖和糖尿病的关联
生物世界· 2025-09-07 01:00
Core Viewpoint - The study highlights the significant role of the oral virome in human health, particularly its connection to obesity and type 2 diabetes, and introduces the Human Oral Virome Database (HOVD) as a valuable resource for understanding these relationships [3][5][7]. Group 1: Research Findings - The research team constructed the Human Oral Virome Database (HOVD), which includes 24,440 viral operational taxonomic units (vOTUs) and 83 eukaryotic viruses, providing a comprehensive resource for studying oral viromes [3][5][7]. - The study found that the oral virome diversity is reduced in obese patients with type 2 diabetes, indicating a weak correlation with clinical features and enhanced oral-gut virus transmission [6][7]. - The research identified phages that infect Porphyromonas gingivalis, a key pathogen in periodontal disease, and screened for six potential endolysins that can inhibit its growth, suggesting a new therapeutic avenue for managing periodontal disease associated with type 2 diabetes [6][7]. Group 2: Implications for Disease Understanding - The findings suggest that oral viruses may influence the progression of diseases such as oral cancer, periodontal disease, and rheumatoid arthritis, indicating potential prognostic and diagnostic applications based on microbiome composition [5][6]. - The study enhances understanding of host-virus interactions within the oral microbiome and provides new insights for the diagnosis and treatment of human diseases [9].