古DNA技术

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Cell Reports:王轲/金力/李辉团队破译史前黄土高原人群基因密码,揭示南方基因的“远程输入”
生物世界· 2025-09-05 08:00
编辑丨王多鱼 排版丨水成文 考古 人类学 研究 依据出土 器物、 考古 遗址的 相似性, 推测 文化 交流的范围和方向。而 基因 作为 人 群 " 血脉的档案 " , 则 直接揭示 史前 人群 间 的真实互动。 近日,复旦大学 王轲 / 金力 / 李辉 团队在 Cell Reports 期刊 发表了题为: Ancient genomes from the Yellow River Bend reveal long-distance population interactions between the Central Plains, Steppe, and southern China 的研究论文。 该研究利用 古 DNA 破译了史前黄土高原上,北方草原、中原与南方人群远距离互动的 遗传 历史,为多元 史前 文明汇聚 碰撞 于此提供了确凿的遗传学证据。 值得一提的是, Cell Reports 期刊 同期配发了 对于论文通讯作者 王轲 博士的个人专访,聚焦青年科学家 成长 及其 对于古 DNA 业界未来研究趋势的展望。 黄河 自青藏高原奔流而下,在陕北形成一个巨大的 " 几 " 字形弯道,这里既是农耕文明 区 ...
华人学者一天发表了9篇Nature论文
生物世界· 2025-06-05 08:29
Core Insights - The article highlights significant research advancements published in the journal Nature on June 4, 2025, with a notable contribution from Chinese scholars, indicating a growing influence in the global scientific community [2][3][6][8]. Group 1: Medical Innovations - A new thrombectomy technique called "Milli-spinner thrombectomy" was developed, demonstrating over twice the efficiency of existing methods in clearing blood clots, which could enhance treatment success rates for stroke, heart disease, and pulmonary embolism [2]. - Research identified CREM as a critical regulatory factor in NK cell function, suggesting its potential as a therapeutic target to enhance CAR-NK cell anti-tumor efficacy [3]. - A study revealed a novel mechanism of red blood cell hemolysis induced by ischemic endothelial necroptosis in COVID-19 patients, proposing a new therapeutic intervention to alleviate microvascular obstruction [7]. Group 2: Genetic and Archaeological Discoveries - The study utilizing ancient DNA confirmed the existence of a two-clanned matrilineal community in Neolithic China, providing insights into early human social structures [2]. - Research on human Pol III transcription initiation offered structural insights that could enhance understanding of non-coding RNA synthesis regulation [8]. - The discovery of the preference of the human chromatin remodeler SMARCAD1 for subnucleosomes highlights its role in maintaining pluripotency in mouse embryonic stem cells [8]. Group 3: Technological Developments - A new method using a non-natural micropeptide called "killswitch" was developed to probe condensate microenvironments, linking these environments to cellular functions [4]. - The introduction of a soft-clamped topological waveguide for phonons represents a significant advancement in the field of phononic devices [5].