小孢子命运重编程

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华人学者本周发表4篇Cell论文:玫瑰花香调控基因的从头诞生、肿瘤劫持巨噬细胞以促进骨转移和贫血、破译乳腺癌起源和进展...
生物世界· 2025-09-07 09:00
Group 1 - The article highlights seven research papers published in the prestigious journal Cell during the week of September 1 to September 7, 2025, with four of them authored by Chinese scholars [3] - The first study discusses a newly discovered gene SCREP that drives the diversification of rose scent, revealing a multi-step process of its origin and its role in inhibiting the synthesis of the key aromatic compound eugenol [5][8] - The second study presents a breakthrough in the reprogramming of microspore fate, establishing a new technique for efficient in vivo haploid induction without stress treatment, highlighting the roles of the transcription factors BBM and BAR1 [10][12][13] Group 2 - The third study uncovers how cancer cells hijack iron-rich macrophages to promote bone metastasis and anemia, providing insights into potential therapies to mitigate these conditions [15][18] - The fourth study introduces a high-throughput, high-precision single-cell DNA and RNA multi-omics technology called wellDR-seq, which decodes the mechanisms of breast cancer progression by integrating single-cell genomes and transcriptomes [20][23]
贵州师范大学×武汉大学×湖北大学合作发表最新Cell论文
生物世界· 2025-09-04 00:00
撰文丨王聪 编辑丨王多鱼 排版丨水成文 通过经受 胁迫处理 (例如高温、营养饥饿等) 的植物 小孢子 ( microspore, 未成熟的花粉) 培养诱 导单倍体,从而获得单倍体植株, 这一方法已受到半个多世纪的广泛关注,能够显著加快 作物自交系制备 和 品种改良进程。然而, 胁迫处理中 小孢子的细胞命运转变的分子机制,我们仍知之甚少。 2025 年 9 月 3 日, 孙蒙祥 教授领导的武汉大学赴贵州师范大学帮扶团专家团队与 湖北大学生命科学学 院 罗盼 副教授 团队合作 ( 史册 博士为第一作者 ) ,在国际顶尖学术期刊 Cell 上发表了题为 : Reprogramming of microspore fate via BBM-BAR1 for highly efficient in vivo haploid induction 的研 究论文, 贵州师范大学为该论文第一单位。 该研究揭示了 小孢子命运重编程 的关键分子机制,并基于该机制建立了一个 无需胁迫处理即可在体内高 效诱导单倍体 的新技术,在解析细胞命运调控机制和单倍体育种技术领域取得了重要突破。 在这项最新研究中,研究团队证明了,胁迫处理会诱导小 ...