Group 1 - The article highlights seven research papers published in the prestigious journal Cell during the week of September 1 to September 7, 2025, with four of them authored by Chinese scholars [3] - The first study discusses a newly discovered gene SCREP that drives the diversification of rose scent, revealing a multi-step process of its origin and its role in inhibiting the synthesis of the key aromatic compound eugenol [5][8] - The second study presents a breakthrough in the reprogramming of microspore fate, establishing a new technique for efficient in vivo haploid induction without stress treatment, highlighting the roles of the transcription factors BBM and BAR1 [10][12][13] Group 2 - The third study uncovers how cancer cells hijack iron-rich macrophages to promote bone metastasis and anemia, providing insights into potential therapies to mitigate these conditions [15][18] - The fourth study introduces a high-throughput, high-precision single-cell DNA and RNA multi-omics technology called wellDR-seq, which decodes the mechanisms of breast cancer progression by integrating single-cell genomes and transcriptomes [20][23]

撰文丨王聪 编辑丨王多鱼 排版丨水成文 基因的出现归因于多种过程，包括基因复制 - 趋异、转座元件驯化、水平基因转移、基因融合与分裂以及从非编码序列中从头起源。尽管从头起源曾被视为罕见 现象，但新出现的证据表明其发生频率相当高。然而，仅有少数研究报道了通过多个进化步骤从零开始构建基因的情况。此外，对于这些新形成的基因如何实现 增强表达并融入现有的基因调控网络从而影响表型进化，我们的理解仍然有限。 | 2025 年 | 9 月 | 2 日， | 华中农业大学 | | 宁国贵 | 教授团队 | （ | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 李亚军 | | 、 | | 李润慧 | 、 尚均忠 | | 、 | 赵凯歌 | | | 为共同第一作者 | | | | ） | 在国际顶尖学术期刊 | Cell | 上发表了题 | | | | 为： | | A | | de novo | | -originated gene drives rose scent diversification | | | 的研究论 | | 文。 | ...

Core Viewpoint - The research conducted by a team from Huazhong Agricultural University reveals that a new functional gene can originate "from scratch," challenging the long-held belief that new genes arise from existing ones through errors in replication or fusion [1][3]. Group 1: Research Findings - The study published in the journal "Cell" details a multi-step process for the emergence of a new gene named SCREP, which significantly inhibits the synthesis of a key aromatic compound, eugenol, in roses [1][3]. - The SCREP gene's origin involved a non-coding DNA segment that appeared approximately 63 million years ago, which evolved into a complete protein-coding gene framework over 16 million years, aided by the insertion of a "jumping gene" known as MITE [3][4]. - Genetic sequencing and aroma component analysis of 38 rose species revealed that the SCREP gene is commonly found in more evolved or artificially selected rose varieties, indicating its role in shaping the aromatic characteristics of these plants [3]. Group 2: Implications and Applications - This discovery provides a theoretical basis for the targeted regulation of floral scent traits in roses and holds significant potential for synthetic biology applications [4]. - The research opens avenues for creating new genes from scratch, moving beyond traditional methods that rely on modifying existing genes to improve plant traits [4].