撰文丨王聪 编辑丨王多鱼 排版丨水成文 心房颤动 （ Atrial Fibrillation， 简称 房颤 ） 是最常见的持续性心律失常，会导致心力衰竭和血栓栓塞性中风，从而造成相当高的死亡率和发病率。房颤的社会 经济后果严重，且管理不足。在标准治疗方案中，复律、导管消融或抗心律失常药物治疗可恢复窦性心律，但房颤往往会复发。抗凝血治疗可预防血栓栓塞性中 风，但存在出血风险。因此，迫切需要更好地了解引发房颤的途径，从而帮助开发有效且安全的治疗方法。 2025 年 10 月 8 日，哈佛大学医学院麻省总医院的研究人员在 Nature 子刊 Nature Cardiovascular Research 上发表了题 为： B cells promote atrial fibrillation via autoantibodies 的研究论文。 该研究表明，在具有房颤 典型风险因素 （高血压、肥胖和二尖瓣反流，简称为 HOMER） 小鼠中， B 细胞 通过产生致心律失常的 自身抗体 促进心肌细胞不良 电重构并引发房颤。而使用 抗 CD20 单克隆抗体靶向清除 B 细胞，可显著降低 HOMER 小鼠的房颤发生率。这项研究 ...

Core Viewpoint - The article discusses the symptoms of numbness that may indicate the early signs of a stroke, emphasizing the importance of recognizing these symptoms for timely medical intervention [1][3]. Group 1: Symptoms of Stroke - Numbness in three specific areas—tongue, face, and one-sided limbs—should raise concerns about the risk of stroke [3][5][6]. - Tongue numbness can affect speech and swallowing, indicating potential brain blood supply issues [5]. - Facial numbness may lead to asymmetrical facial expressions, signaling possible nerve damage due to insufficient blood flow [5]. - One-sided limb numbness is a common precursor to stroke, often indicating that one side of the brain is affected [6]. Group 2: Characteristics of Numbness Related to Stroke - Numbness from cerebrovascular diseases typically occurs suddenly without warning, and may happen during rest or physical activity [6][7]. - It is often unilateral, affecting one side of the body, and can progress from transient to persistent numbness as blood supply issues worsen [6]. - Unlike numbness caused by other conditions, such as cervical or lumbar spine issues, stroke-related numbness does not improve with position changes [7]. Group 3: Accompanying Symptoms - Stroke-related numbness is often accompanied by weakness, dizziness, headaches, vision problems, and memory decline [8]. - Other alarming signs include sudden dizziness, vomiting, tinnitus, and instability while standing [8]. Group 4: Risk Factors for Stroke - Stroke risk factors include both uncontrollable factors (age, gender, genetic background) and controllable factors (hypertension, diabetes, high cholesterol, smoking, and poor lifestyle choices) [9]. - Sedentary behavior can increase blood viscosity and lead to plaque formation in blood vessels, heightening stroke risk [10]. - High salt and oil intake can elevate blood pressure and cholesterol levels, contributing to vascular damage [12]. - Emotional fluctuations and severe snoring during sleep can also increase the likelihood of stroke by affecting blood pressure and oxygen levels [14][16]. Group 5: Recommendations for Prevention - It is advised to take breaks from sitting every hour to promote blood circulation [11]. - Daily salt intake should be limited to under 5 grams, and healthier cooking oils should be used [13]. - Stress management techniques, such as deep breathing and meditation, are recommended to mitigate emotional impacts on vascular health [14]. - Individuals experiencing severe snoring should adjust their sleeping positions and seek medical evaluation [17]. - Smoking cessation is crucial, as smokers face a significantly higher risk of stroke compared to non-smokers [18].