Core Viewpoint - The article emphasizes the potential health benefits of mango consumption, particularly its role in improving insulin sensitivity and metabolic health in overweight or obese individuals with chronic low-grade inflammation [3][10]. Summary by Sections Blood Sugar Regulation - Blood sugar is a crucial health indicator, with normal fasting levels between 3.9-6.1 mmol/L and postprandial levels not exceeding 7.8 mmol/L. Dietary choices significantly impact blood sugar control, where a balanced diet stabilizes blood sugar, while poor eating habits can lead to spikes [3]. Mango's Nutritional Benefits - Mango is highlighted for its high dietary fiber content and various vitamins and minerals. Previous studies have shown that moderate mango intake may positively affect blood sugar regulation and inflammation [3][10]. Clinical Study Overview - A recent randomized, placebo-controlled trial involved 48 participants with specific metabolic characteristics, including a BMI of ≥25 kg/m² and fasting blood glucose levels between 100-126 mg/dL. Participants were divided into two groups: one consuming fresh mango (approximately 230 grams daily) and the other receiving a mango-flavored placebo drink [6][7]. Study Findings - After four weeks, the study assessed blood sugar control using the oral glucose tolerance test (OGTT) and measured various metabolic parameters. Results indicated that regular mango consumption significantly improved insulin sensitivity, evidenced by decreased fasting insulin levels and improved HOMA-IR index [7][9]. Inflammation Markers - No significant statistical differences were found in inflammation markers between the mango and control groups, suggesting that mango's effect on insulin sensitivity may not directly involve inflammation pathways. The study primarily focused on IL-6, TNF-α, and hs-CRP, leaving out other relevant inflammatory markers [8]. Nrf-2 Gene Expression - An interesting finding was the approximately twofold increase in Nrf-2 gene expression in the mango group, although not statistically significant. Nrf-2 is crucial for activating antioxidant genes, which may enhance cellular antioxidant defenses and alleviate oxidative stress, potentially explaining the improvement in insulin sensitivity [9][10]. Conclusion and Future Research - The study concludes that mango, rich in active polyphenols and antioxidants, may serve as a dietary intervention for improving insulin resistance. Further research is recommended to explore the mechanisms and broader health benefits of mango consumption [10][11].