Core Viewpoint - The collaboration between Heptares Therapeutics and AstraZeneca aims to advance the discovery and development of next-generation biotherapies, including antibody-drug conjugates (ADCs) and T cell engagers (TCEs) [1] Group 1: Collaboration Details - Heptares Therapeutics will update and deepen its global strategic collaboration with AstraZeneca established in March 2025 [1] - AstraZeneca will nominate research and development projects to Heptares annually over the next four years, retaining the option to license these projects [1] - Heptares is eligible to receive option fees, exercise fees, development and commercial milestone payments, as well as tiered royalties based on future net sales of licensed projects [1] Group 2: Financial Terms - The economic terms of the collaboration remain consistent with the financial framework agreed upon by both parties in March 2025 [1]

Core Viewpoint - The collaboration between Heptagon Pharmaceuticals and AstraZeneca aims to leverage both companies' expertise to discover and develop next-generation biotherapies, including antibody-drug conjugates (ADCs) and T-cell engagers [1] Group 1: Collaboration Details - Heptagon Pharmaceuticals' indirect wholly-owned subsidiary, Heptagon (Shanghai) Co., Ltd., has entered into a collaboration, option, and licensing agreement with AstraZeneca [1] - The scope of cooperation has been further expanded following the revised collaboration agreement signed on November 24, 2025 [1] - The financial framework established under the collaboration agreement remains consistent with previous terms [1]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不就因本公告全部或任何部分內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 和鉑醫藥控股有限公司 HBM Holdings Limited （於開曼群島註冊成立的有限公司） 主席兼執行董事 王勁松博士 香港，2025年11月24日 茲提述本公司日期為2025年3月21日的公告，內容有關（其中包括）本公司的間 接全資附屬公司和鉑醫藥（上海）有限責任公司（「和鉑上海」）與AstraZeneca PLC （「AstraZeneca」）訂立合作、選擇權及許可協議（「合作協議」）。 本公司董事會（「董事會」）欣然宣佈，於2025年11月24日，經修訂和鉑上海與 AstraZeneca訂立之合作協議（「該修訂」）後，訂約雙方的合作範圍進一步擴展，旨 在結合兩家公司之專業知識，共同發現及開發包括抗體偶聯藥物(ADC)及T細胞銜 接器在內的新一代生物療法。經濟條款與合作協議項下建立的財務框架仍然一致。 警示聲明 我們無法保證我們或合作夥伴將能成功開發或最終銷售本公告所提述的任何候選 產品。本公 ...